A5071149112- Neonatal Respiratory Health Research
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Prenatal Screening and Diagnostics
- Maternal and fetal healthcare
- Fetal and Pediatric Neurological Disorders
- Assisted Reproductive Technology and Twin Pregnancy
- Maternal and Perinatal Health Interventions
- Congenital Diaphragmatic Hernia Studies
- Gestational Diabetes Research and Management
- Hemoglobinopathies and Related Disorders
- Neonatal and fetal brain pathology
- Iron Metabolism and Disorders
- Neuroscience of respiration and sleep
- Infant Development and Preterm Care
- Cardiovascular Issues in Pregnancy
- Genomic variations and chromosomal abnormalities
- Electrolyte and hormonal disorders
- Preterm Birth and Chorioamnionitis
- Medical and Health Sciences Research
- Uterine Myomas and Treatments
- Erythropoietin and Anemia Treatment
- Pregnancy and Medication Impact
- Endometriosis Research and Treatment
- Pregnancy-related medical research
University Hospital of Zurich
2015-2024
University of Zurich
2009-2024
Klinik für Frauenheilkunde
2007-2024
Olgahospital
2017-2024
Universitätsklinik für Frauenheilkunde und Geburtshilfe
2005-2022
Hospital Base
2022
Kantonsspital Frauenfeld
2017
Kantonsspital Baden
2016
University Children's Hospital Zurich
2016
University of Basel
2016
In Brief Objective: To analyze the effect of nuchal cords on perinatal features at delivery term and postterm pregnancies. Methods: A total 11,748 women with planned vaginal deliveries, including 9,574 2,174 were analyzed for intrapartum events, clinical peripartum management, mode delivery, neonatal outcome. The presence was diagnosed clinically time delivery. Data obtained from our database between 1995 2004 retrospective analysis. Results: incidence in deliveries 33.7% 35.1%,...
First-trimester screening between 11 + 0 and 13 6 weeks with qualified prenatal counseling, detailed ultrasound, biochemical markers maternal factors has become the basis for decisions about further examinations. It detects numerous structural genetic anomalies. The inclusion of uterine artery Doppler PlGF screens preeclampsia fetal growth restriction. Low-dose aspirin significantly reduces prevalence severe preterm eclampsia. Cut-off values define groups high, intermediate low probability....
Objective: To determine the accuracy of birth weight in different (BW) groups using widely accepted formulas for fetal estimation (EFW). The secondary purpose was to estimate role examiners on EFW. Methods: cross-sectional data were obtained from 5612 pregnant women. Fetal estimated each fetus Campbell and Wilkin, Shepard, 2 Hadlock Merz. Inclusion criteria were: singleton pregnancy, complete ultrasound parameters, EFW within last week prior delivery, live born infant without congenital...
Key words chromosomal aberration - Down syndrome genetic defects laboratory tests ultrasound
In Brief OBJECTIVE: To analyze hypothalamic-pituitary-adrenal axis balance in healthy newborns after antenatal betamethasone treatment for lung maturation where delivery could be prolonged until or near term. METHODS: a prospective observational study, salivary cortisol and cortisone levels were measured at the fourth day of life during resting conditions response to pain-induced stress event 23 neonates with exposure single course (2×12 mg) compared 40 controls. The mean interval between...
Objective The objective of this study is to validate the diagnostic accuracy a non-invasive prenatal test for detecting trisomies 13, 18, and 21 population in Germany Switzerland. Methods Random massively parallel sequencing was applied using Illumina platform HiSeq2000. Fetal aneuploidies were identified median absolute deviation based z-score equation. A bioinformatics algorithm on guanine-cytosine normalization after data unblinded. Results invasive procedures compared. Overall, 40/42...
Context:Copeptin is a stable by-product of arginine-vasopressin synthesis and reflects its secretion by the pituitary.
OBJECTIVE: To evaluate postpartum blood loss in women with treated intrahepatic cholestasis of pregnancy. METHODS: In a retrospective case–control study, 15,083 deliveries including 348 pregnancy (2.3%) were analyzed from 2004 to 2014. adjust for differences baseline characteristics, propensity analysis was performed and the control group matched 5:1 ratio. Blood by estimated Δ hemoglobin (Hb, difference between prepartum Hb). A subgroup regarding severity based on maximum bile acid level...
This extensive AWMF 085-002 S2e-guideline “First Trimester Diagnosis and Therapy @ 11–13+6 Weeks of Gestation” has systematically analyzed high-quality studies publications the existing evidence (evidence tables) produced recommendations (level recommendation, level evidence, strength consensus). guideline deals with following topics in context weeks scan: legal basis, screening for anatomical malformations, chromosomal defects, quality assessment audit, preeclampsia FGR, preterm birth,...
Objective To evaluate the quality of anthropometric measures to improve prediction shoulder dystocia by combining different sonographic biometric parameters. Methods This was a retrospective cohort study 12 794 vaginal deliveries with complete biometry data obtained within 7 days before delivery. Receiver–operating characteristics (ROC) curves various combinations parameters, namely, biparietal diameter (BPD), occipitofrontal (OFD), head circumference, abdominal (AD), circumference (AC) and...
The cardiac sympathetic nervous system is one putative key factor involved in the intrauterine programming of adult cardiovascular disease. We therefore analyzed autonomic activity small for gestational age (SGA) neonates. Heart rate variability (HRV) from 24-h ECG recordings were time-domain and frequency-domain parameters 27 SGA neonates [median 261 (240–283) days gestation] compared with appropriate (AGA) 270 (239–293) gestation]. In addition, salivary α-amylase levels during resting...
To apply the cumulative summation (CUSUM) technique for an evaluation of learning process sonographic fetal weight estimation at term in combination with z-scores biometry determinants and to assess time appearance sources errors.Learning curve (LC-CUSUM) double CUSUM charts systematic error detection based on absolute signed mean percentage were generated retrospectively estimate longitudinal accuracy conducted by three trainees one experienced examiner. For LC-CUSUM analysis examination...
<b><i>Introduction:</i></b> To investigate the ability of cardiovascular plasma biomarkers to identify imminent preeclampsia (PE) among pregnant women at triage. <b><i>Material and Methods:</i></b> C-terminal pro-arginine vasopressin (copeptin), pro-endothelin-1 (CT-proET-1), mid-regional pro-adrenomedullin (MR-proADM), pro-atrial natriuretic peptide (MR-proANP) were prospectively measured in presenting obstetrical triage units University...
The main aim of the present study was to quantify magnitude differences introduced when estimating a given blood volume compartment (e.g. plasma volume) through direct determination another red cell by multiplication venous haematocrit and/or haemoglobin concentration. However, since whole body is higher than such an approach might comprise certain errors. To test this experimentally, four different methods for detecting volumes and mass (Hbmass) were compared, namely carbon monoxide (CO)...
Background: Arginine vasopressin (AVP) regulates water balance and blood pressure plays a role in social behavioral processes.Healthy adult men as compared with women have higher levels of AVP its C-terminal precursor peptide, copeptin. Objective:The objective the study was to investigate whether sexual disparity copeptin is present at birth. Methods:In 241 prospectively enrolled healthy newborn infants, 131 boys 110 girls, plasma concentrations were measured birth on day 3 life.Results:...
This extensive AWMF 085-002 S2e-guideline “First Trimester Diagnosis and Therapy @ 11–13+6 Weeks of Gestation” has systematically analyzed high-quality studies publications the existing evidence (evidence tables) produced recommendations (level recommendation, level evidence, strength consensus). guideline deals with following topics in context weeks scan: legal basis, screening for anatomical malformations, chromosomal defects, quality assessment audit, preeclampsia FGR, preterm birth,...