A5006442525- Neonatal Respiratory Health Research
- Neonatal and fetal brain pathology
- Infant Development and Preterm Care
- Non-Invasive Vital Sign Monitoring
- Optical Imaging and Spectroscopy Techniques
- Neuroscience of respiration and sleep
- Hemodynamic Monitoring and Therapy
- Child and Adolescent Health
- Infant Health and Development
- Dialysis and Renal Disease Management
- Health and Medical Studies
- Birth, Development, and Health
- Childhood Cancer Survivors' Quality of Life
- Neonatal Health and Biochemistry
- Grief, Bereavement, and Mental Health
- Growth Hormone and Insulin-like Growth Factors
- Infant Nutrition and Health
- Electrolyte and hormonal disorders
- Palliative Care and End-of-Life Issues
- Congenital Diaphragmatic Hernia Studies
- Erythropoietin and Anemia Treatment
- Respiratory Support and Mechanisms
- Congenital Heart Disease Studies
- Ethics and Legal Issues in Pediatric Healthcare
- Traumatic Brain Injury and Neurovascular Disturbances
University Hospital of Zurich
2015-2024
University of Zurich
2013-2023
Swiss Epilepsy Center
2022
See-Spital
2011
University Hospital of Basel
2010
West Middlesex University Hospital
2009
Universitätsklinikum des Saarlandes
2004
Klinik für Frauenheilkunde
1990-2003
University Children's Hospital Zurich
1984-2003
Helios Amper-Klinikum Dachau
2002
Neonatal sepsis causes high mortality and morbidity in preterm infants, but less is known regarding the long-term outcome after sepsis. This study aimed to determine impact of on neurodevelopment at 2 years' corrected age extremely infants.This was a multicenter Swiss cohort infants born between 2000 2007 24(0/7) 27(6/7) weeks' gestational age. Neurodevelopmental assessed with Bayley Scales Infant Development-II. impairment (NDI) defined as Mental or Psychomotor Developmental Index lower...
OBJECTIVE. Erythropoietin has been shown to be protective against hypoxic-ischemic and inflammatory injuries in cell culture, animal models of brain injury, clinical trials adult humans. The rationale for our study was that early administration high-dose recombinant human erythropoietin may reduce perinatal injury (intraventricular hemorrhage periventricular leukomalacia) very preterm infants improve neurodevelopmental outcome. We investigated whether shortly after birth subsequently during...
<h3>Importance</h3> Premature infants are at risk of developing encephalopathy prematurity, which is associated with long-term neurodevelopmental delay. Erythropoietin was shown to be neuroprotective in experimental and retrospective clinical studies. <h3>Objective</h3> To determine if there an association between early high-dose recombinant human erythropoietin treatment preterm biomarkers prematurity on magnetic resonance imaging (MRI) term-equivalent age. <h3>Design, Setting,...
Over the last two decades, improvements in medical care have been associated with a significant increase and better outcome of very preterm (VP, < 32 completed gestational weeks) low birth weight (VLBW, 1500 g) infants. Only few publications analyse changes their short-term geographically defined area over more than 10 years. We therefore aimed to investigate net change VP- VLBW infants leaving hospital without major complications. Our population-based observational cohort study used Minimal...
Abstract Background While survival rates of extremely preterm infants have improved over the last decades, incidence neurodevelopmental disability (ND) in survivors remains high. Representative current data on severity and risk factors associated with poor outcome this growing population are necessary for clinical guidance parent counselling. Methods Prospective longitudinal multicentre cohort study born Switzerland between 24 0/7 27 6/7 weeks gestational age during 2000–2008. Mortality,...
<h3>Importance</h3> Very preterm infants are at risk of developing encephalopathy prematurity and long-term neurodevelopmental delay. Erythropoietin treatment is neuroprotective in animal experimental human clinical studies. <h3>Objective</h3> To determine whether prophylactic early high-dose recombinant erythropoietin (rhEPO) improves outcome 2 years' corrected age. <h3>Design, Setting, Participants</h3> Preterm born between 26 weeks 0 days' 31 6 gestation were enrolled a randomized,...
Despite improved survival, many preterm infants undergo subsequent neurodevelopmental impairment. To date, no neuroprotective therapies have been implemented into clinical practice. Erythropoietin, a haematopoietic cytokine used for treatment of anaemia prematurity, has shown to and neuroregenerative effects on the brain in experimental studies. The aim study was assess effect recombinant human erythropoietin microstructural development cerebral white matter using tract-based spatial...
We studied insulin-like growth factors (IGF) I and II, prolactin, the insulin response to arginine in 19 children with craniopharyngioma documented hormone deficiency. Patients were divided into three groups according their rate during first postoperative year. Seven patients excessive (Group A) had hyperinsulinism, normal IGF values, elevated basal prolactin levels, a delayed thyrotropin thyrotropin-releasing hormone, which was compatible hypothalamic lesions. In six B), level low; all...
To assess grief and post-traumatic growth in parents 2-6 years after the death of a premature baby (24-26 weeks' gestation) to evaluate Pictorial Representation Illness Self-Measure (PRISM) assessment bereavement.Fifty-four were assessed for their experiences during hospitalization by questionnaires regarding (MTS), growth, affective symptoms visual representation self (PRISM).Even loss extremely preterm infant still suffer lot from bereavement, mothers more so than fathers (Mann-Whitney U...
Premature birth is stressful for infants and parents can adversely affect the parent–infant dyad. This mixed-methods pilot study evaluates whether creative music therapy (CMT) alleviate anxiety, stress, depressive symptoms in support bonding process with their infant. Sixteen parent couples were included. Ten randomly allocated to group (MTG) six control (CG). All completed psychological questionnaires measuring anxiety as well an implicit measure of attachment at two weeks postpartum (T1),...
ABSTRACT Objective The neonatal abstinence scoring system proposed by Finnegan is used widely in units to initiate and guide therapy babies of opiate‐dependent mothers. purpose this study was assess the variability scores newborns infants not exposed opiates during first 3 days life consecutive weeks 5 or 6. Patients methods Healthy neonates born after 34 completed gestation, whose parents denied opiate consumption gave informed consent, were included observational study. Infants with signs...
Intrauterine conditions may interfere with foetal brain development. We compared the neurodevelopmental outcome between infants <32 weeks gestational age after maternal preeclampsia or chorioamnionitis and controls.Case-control study on preeclampsia, controls (each n = 33) matched for age. Neurodevelopment at 2 years was assessed Bayley Scales of Infant Development II.A total 99 were included a median 29 (range 25-32). Median mental developmental index (MDI) 96 in control, 90 86 group....
In the last 20 years, chances for intact survival extremely preterm infants have increased in high income countries. Decisions about withholding or withdrawing intensive care remain a major challenge born at limits of viability. Shared decision-making regarding these fragile between health professionals and parents has become preferred model today. However, there is an ongoing ethical debate on how decisions life-sustaining treatment should be reached who final word when do not agree. We...
Outcomes of very preterm infants vary considerably between health care facilities. Our objective was to compare outcome and practices the Swiss Neonatal Network (SNN) US members Vermont Oxford (US-VON).Retrospective observational study including all live-born with a birth weight 501 1500 g as registered by SNN US-VON 2012 2014. We performed multivariable propensity score-matched analyses neonatal adjusting for case-mix, race, prenatal care, unit-level factors, compared indirectly...
Motor performance and movement quality were quantitatively examined (Zurich Neuromotor Assessment: timed motor performances associated movements) in 87 prospectively enrolled very-low-birthweight (VLBW; <1250g) children (38 males, 49 females; mean birthweight 1016.2g [SD 141.5]:, range 720-1240g; gestational age 28.7wks 2], 25.7-33.4wks) at 6 years of age. All tasks below the reference population: pure (median z-score) -0.46; adaptive fine (pegboard) -0.99; gross -0.88; static balance -0.48;...
Abstract Brain activity is associated with physiological changes, which alter the optical properties of tissue. These changes can be detected by near‐infrared spectroscopy (NIRS). Aim study was to determine in cerebral oxygenation response stimulation visual cortex newborn infants during spontaneous sleep first days life. We used an in‐house developed multichannel NIRS imaging instrument, MCP‐II, measure concentration oxyhemoglobin (O 2 Hb) and deoxyhemoglobin (HHb) specific brain areas. In...
Context: The pituitary-secreted nonapeptide arginine-vasopressin (AVP) is unstable and therefore unsuited for diagnostic use, but its secretion can be estimated by measuring copeptin, the C-terminal portion of AVP precursor (pro-AVP). Objective: Our objective was to investigate perinatal factors affecting copeptin concentrations in infants at birth 3 d life. Design Setting: We conducted a prospective cross-sectional study tertiary university hospital. Patients: Copeptin plasma were evaluated...
Accurate tube placement of orogastric and nasogastric feeding tubes in neonates is important to ensure safe effective enteral feeding. Errors position are described literature, but there little evidence the exact prevalence improperly placed tubes, especially neonates.To evaluate we reviewed 381 consecutive radiographs defined tubes.We found that 41% placements, optimal was achieved, whereas overall 59% had been incorrectly.There a need for both better rules measure distance between nose...
OBJECTIVE: To examine whether cycled lighting (CL) conditions during neonatal care in very preterm infants (&lt;32 weeks’ gestational age [GA]) decrease crying and fussing behavior, improve the consolidation of sleep, influence activity behavior at 5 11 postterm corrected (CA) compared with cared for dim (DL) conditions. METHODS: Thirty-seven were randomly assigned to CL (7 am–7 pm lights on, 7 pm–7 am off [n = 17; mean GA: 30.6 ± 0.95 weeks; 9 girls]) or DL (lights whenever child is...