A5080212801- Neonatal Respiratory Health Research
- Neonatal and fetal brain pathology
- Infant Development and Preterm Care
- Congenital Diaphragmatic Hernia Studies
- Neuroscience of respiration and sleep
- Congenital Heart Disease Studies
- Anesthesia and Neurotoxicity Research
- Neonatal Health and Biochemistry
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Respiratory Support and Mechanisms
- Gestational Diabetes Research and Management
- Infant Nutrition and Health
- Breastfeeding Practices and Influences
- Birth, Development, and Health
- Metabolism and Genetic Disorders
- Cardiovascular Conditions and Treatments
- Child and Adolescent Health
- Chronic Disease Management Strategies
- Childhood Cancer Survivors' Quality of Life
- Health and Medical Studies
- Obesity and Health Practices
- Retinopathy of Prematurity Studies
- Pregnancy and preeclampsia studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Diabetes Management and Research
Charité - Universitätsmedizin Berlin
2016-2025
Humboldt-Universität zu Berlin
2006-2024
Freie Universität Berlin
1994-2024
Deutsche Akademie für Kinder- und Jugendmedizin
2014-2023
University of Zurich
2023
Swiss Paediatric Oncology Group
2023
Swiss Epilepsy Center
2022
Roche (Switzerland)
2022
Federal Ministry of Health
2022
Karlsruhe University of Education
2022
Treatment of respiratory distress syndrome in premature infants with continuous positive airway pressure (CPAP) preserves surfactant and keeps the lung open but is insufficient severe deficiency. Traditional administration related to short periods ventilation implies risk injury. CPAP without any may work synergistically. This randomized trial investigated a less invasive application protocol (LISA).To test hypothesis that LISA increases survival bronchopulmonary dysplasia (BPD) at 36 weeks'...
<h3>Importance</h3> Red blood cell transfusions are commonly administered to infants weighing less than 1000 g at birth. Evidence-based transfusion thresholds have not been established. Previous studies suggested higher rates of cognitive impairment with restrictive thresholds. <h3>Objective</h3> To compare the effect liberal vs red strategies on death or disability. <h3>Design, Setting, and Participants</h3> Randomized clinical trial conducted in 36 level III/IV neonatal intensive care...
The transcriptional regulation of several dozen genes in response to low oxygen tension is mediated by hypoxia-inducible factor 1 (HIF-1), a heterodimeric protein composed two subunits, HIF-1α and HIF-1β. In the HIF-1α-deficient human leukemic cell line, Z-33, exposed mild (8% O2) or severe (1% hypoxia, we found significant upregulation related heterogenous nuclear ribonucleoproteins, RNA-binding motif 3 (RBM3) cold inducible (CIRP), which are highly conserved stress proteins with...
OBJECTIVE—To investigate the growth of children from pregnancies with gestational diabetes mellitus (GDM) and its association antenatal maternal, fetal, recent anthropometric parameters mother father. RESEARCH DESIGN AND METHODS—In 324 Caucasian women GDM, BMI before pregnancy, maternal glycemic values, measurements fetal abdominal circumference were recorded. The weight height infants measured at birth follow-up 5.4 years (range 2.5–8.5). In addition, somatic data routine examinations 6,...
In preterm human infants, briefly elevated concentrations of oxygen are associated with a prolonged increase in blood chemokine and the development bronchopulmonary dysplasia (BPD). Caffeine given to infants for prevention or treatment apnoea has been shown reduce rate BPD. We tested hypotheses that infant rats exposed combination caffeine hyperoxia would be less susceptible lung injury than those alone decreases pulmonary tissue expression chemokines leukocyte influx following hyperoxia....
Object Neonatal intraventricular hemorrhage (IVH) may evolve into posthemorrhagic hydrocephalus and cause neurodevelopmental impairment. In this study, an endoscopic surgical approach directed toward the removal of hematoma was evaluated for its safety efficacy. Methods Between August 2010 December 2012 (29 months), 19 neonates with underwent neuro lavage blood remnants. During a similar length time months) from March 2008 to July 2010, 10 were treated conventionally, initially using...
Sequelae of prematurity triggered by oxidative stress and free radical-mediated tissue damage have coined the term "oxygen radical disease prematurity". Caffeine, a potent scavenger adenosine receptor antagonist, reduces rates brain in preterm infants. In present study, we investigated effects caffeine on markers, anti-oxidative response, inflammation, redox-sensitive transcription factors, apoptosis, extracellular matrix following induction hyperoxia neonatal rats. The rat pups at postnatal...
Abstract Individuals with ultrarare disorders pose a structural challenge for healthcare systems since expert clinical knowledge is required to establish diagnoses. In TRANSLATE NAMSE, 3-year prospective study, we evaluated novel diagnostic concept based on multidisciplinary expertise in Germany. Here present the systematic investigation of phenotypic and molecular genetic data 1,577 patients who had undergone exome sequencing were partially analyzed next-generation phenotyping approaches....
Glutamate antagonists limit the growth of human cancers in vitro . The mechanism anticancer action NMDA is not known, however. In this article, we report that antagonist dizocilpine inhibits extracellular signal-regulated kinase 1/2 pathway, an intracellular signaling cascade activated by factors and controls proliferation cancer cells. Dizocilpine reduces phosphorylation cAMP-responsive element binding protein, suppresses expression cyclin D1, up-regulates cell cycle regulators tumor...
OBJECTIVE—To compare the management of Caucasian women with gestational diabetes (GDM) based predominantly on monthly fetal growth ultrasound examinations an approach solely maternal glycemia. RESEARCH DESIGN AND METHODS—Women GDM who attained fasting capillary glucose (FCG) &lt;120 mg/dl and 2-h postprandial (2h-CG) &lt;200 after 1 week diet were randomized to glycemia alone (standard) or plus ultrasound. In standard group, insulin was initiated if FCG repeatedly &gt;90 2h-CG...
Abstract Traumatic brain injury is followed by increased extracellular glutamate concentration. Uptake of mainly mediated the glial transporters GLAST and GLT‐1. Extent distribution GLT‐1 were studied in a rat model controlled cortical impact (CCII). Western Blot analysis revealed lowest levels with decrease 40%–54% 42%–49% between 24 72 h posttrauma. By 8 after CCII, CSF (10.5 μM vs. 2.56 controls; P < 0.001), reaching maximum values 48 h. A significant increase de novo expressing...
Cell-surface gangliosides are presumed to play a role in cell growth and differentiation. With the use of monoclonal antibodies directed against GD3, disialoganglioside expressed predominantly by cells neuroectodermal origin, we have found that GD3 is subpopulation immune system including: 1) fetal thymocytes subcortical regions near vessels, 2) lymph node lymphocytes interfollicular areas 3) small subset T peripheral blood. Mouse (two IgGs, one IgM, F(ab')2 fragments) reacting with were...