A5110002977- Neonatal Respiratory Health Research
- Infant Development and Preterm Care
- Neuroscience of respiration and sleep
- Congenital Diaphragmatic Hernia Studies
- Infant Health and Development
- Infant Nutrition and Health
- Respiratory Support and Mechanisms
- Birth, Development, and Health
- Congenital Heart Disease Studies
- Airway Management and Intubation Techniques
- Neonatal and fetal brain pathology
- Pediatric Pain Management Techniques
- Pregnancy and preeclampsia studies
- Breastfeeding Practices and Influences
- Child and Adolescent Health
- Maternal Mental Health During Pregnancy and Postpartum
- Neonatal Health and Biochemistry
- Pediatric Urology and Nephrology Studies
- Neonatal and Maternal Infections
- Reproductive System and Pregnancy
- Assisted Reproductive Technology and Twin Pregnancy
- Neonatal skin health care
- Preterm Birth and Chorioamnionitis
- Child and Adolescent Psychosocial and Emotional Development
- Family and Patient Care in Intensive Care Units
University Hospital Cologne
2016-2025
University of Cologne
2016-2025
Klinik und Poliklinik für Kinder- und Jugendmedizin
2005-2024
Universitätskinderklinik
2004-2023
LVR-Klinik Köln
2023
RELX Group (United States)
2021
University of Siegen
2021
Beth Israel Deaconess Medical Center
2011-2015
Harvard University
2011-2015
Centrum für Integrierte Onkologie
2014
Background— Targeted therapies to stabilize the clinical manifestations and prolong pregnancy in preeclampsia do not exist. Soluble fms-like tyrosine kinase 1 (sFlt-1), an alternatively spliced variant of vascular endothelial growth factor receptor 1, induces a preeclampsia-like phenotype experimental models circulates at elevated levels human preeclampsia. Removing sFlt-1 may benefit women with very preterm (<32 weeks) Methods Results— We first show that negatively charged dextran...
Treatment of respiratory distress syndrome in premature infants with continuous positive airway pressure (CPAP) preserves surfactant and keeps the lung open but is insufficient severe deficiency. Traditional administration related to short periods ventilation implies risk injury. CPAP without any may work synergistically. This randomized trial investigated a less invasive application protocol (LISA).To test hypothesis that LISA increases survival bronchopulmonary dysplasia (BPD) at 36 weeks'...
Preeclampsia is a devastating complication of pregnancy. Soluble Fms-like tyrosine kinase-1 (sFlt-1) an antiangiogenic protein believed to mediate the signs and symptoms preeclampsia. We conducted open pilot study evaluate safety potential efficacy therapeutic apheresis with plasma-specific dextran sulfate column remove circulating sFlt-1 in 11 pregnant women (20–38 years age) very preterm preeclampsia (23–32 weeks gestation, systolic BP ≥140 mmHg or diastolic ≥90 mmHg, new onset...
Summary Background: Spontaneous breathing supported by nasal continuous positive airway pressure (nCPAP) is thought to have some advantages compared with mechanical ventilation in extremely premature infants. In addition, early or prophylactic surfactant administration has been shown be superior delayed use. A strategy combine these two principles was tested our neonatal intensive care unit (NICU). The aim of this feasibility study describe the procedure and compare short‐term results a...
<i>Background:</i> Apnea and bradycardia of prematurity (ABP) are possible risks towards damage the developing brain. <i>Objectives:</i> To characterize influence neonatal factors on ABP to determine relationship neurodevelopmental outcome. <i>Methods:</i> was described in very low birth weight infants (n = 83) using frequency severity episodes with a clinical score considering heart rate, oxygenation, duration interventions performed during each episode....
Providing less invasive surfactant administration (LISA) to spontaneously breathing preterm infants has been reported reduce mechanical ventilation and bronchopulmonary dysplasia (BPD) in randomised controlled trials. This large cohort study compared these outcome measures between LISA-treated controls.Infants receiving LISA, who were born before 32 gestational weeks enrolled the German Neonatal Network, matched control by age, umbilical cord pH, Apgar-score at 5 min, small for age status,...
<h3>Importance</h3> Rates of survival for infants born at the border viability are still low and vary considerably among neonatal intensive care units. <h3>Objective</h3> To determine whether higher rates better short-term outcomes 22 or 23 weeks’ gestation may be achieved by active prenatal postnatal care. <h3>Design, Setting, Participants</h3> Retrospective study 106 weeks a level III unit University Cologne Medical Centre in Cologne, Germany, between January 1, 2010, December 31, 2014....
Abstract Aim To investigate the effects of 60 minutes delivery room skin‐to‐skin contact (DR‐SSC) compared with 5 visual (VC) on mother‐child interaction (MCI), salivary cortisol, maternal depression, stress and bonding at 6 months corrected age. Methods A single‐centre randomized controlled trial conducted in a German level III NICU. Eighty‐eight preterm infants (25‐32 weeks gestational age) were after initial stabilization to either DR‐SSC or VC. Forty‐five allocated DR‐SSC, 43 Results...
Propofol is gaining increasing popularity as induction agent for pediatric endotracheal intubation. Recently, propofol has been described the first time intubation in preterm neonates. seemed to be efficient, safe and ideally suited INSURE (Intubation SURfactant Extubation) procedure The purpose of this study was document intubating conditions, vital signs, extubation times outcome neonates receiving procedure.Preterm with a gestational age 29-32 weeks respiratory distress were eligible if...
Background: Recently in a report of single center method has been described to apply surfactant via thin endotracheal catheter very low birth weight infants spontaneously breathing with nasal continuous positive airway pressure. We now analyzed available multicenter data.
Abstract Aim: To evaluate the outcome of a cohort extremely low gestational age newborn infants (ELGAN) below 26‐week gestation who were treated following revised, gentle delivery room protocol to assist them in transition and adaptation extrauterine life. Methods: A with (GA) 26 weeks (study group; n = 164) was according revised protocol. The included an optimized prenatal management, strict use continuous positive airway pressure (CPAP), avoiding mechanical ventilation early administration...
Background: It was the aim of this study to assess whether very-low-birth-weight (VLBW) infants born small for gestational age (SGA; birth weight less than 10th percentile) are at increased risk late-onset sepsis. Methods: This a prospective, multicenter German Neonatal Network including VLBW from 23 < 32 weeks post menstrual 2009–2011. Outcomes were compared between SGA (birth tenth percentile according and gender) non-SGA infants. The main outcome measure least 1 episode sepsis defined as...
In a large cohort study of the German Neonatal Network (GNN) we aimed to evaluate whether less invasive surfactant administration (LISA) strategy is associated with complications preterm birth. Within observational period n = 7533 very-low-birth-weight infants (VLBWI) gestational age 22 0/7 28 6/7 weeks were enrolled in GNN; 1214 VLBWI never received surfactant, 2624 treated according LISA procedure, 3695 had via endotracheal tube (ETT). was reduced risk for adverse outcome measures...
AimTo determine whether the use of a respiratory function monitor (RFM) during PPV extremely preterm infants at birth, compared with no RFM, leads to an increase in percentage inflations expiratory tidal volume (Vte) within predefined target range.MethodsUnmasked, randomised clinical trial conducted October 2013 - May 2019 7 neonatal intensive care units 6 countries. Very (24–27 weeks gestation) receiving birth were have RFM screen visible or not. The primary outcome was median proportion...
Importance The inclusion of less invasive surfactant administration (LISA) in the care preterm infants has been found to be beneficial for respiratory outcomes. Recently, OPTIMIST trial higher mortality rates subgroup born at 25 26 weeks’ gestational age (GA) who received treatment while spontaneously breathing. Objective To analyze outcomes among LISA-exposed, highly vulnerable babies than 27 GA within large-scale observational cohort German Neonatal Network. Design, Setting, and...
Abstract Objective: To evaluate whether the experience with a method to administer surfactant during spontaneous breathing nasal continuous positive airway pressure (nCPAP) as primary respiratory support in infants distress syndrome (RDS) influences frequency of its use and affects outcome patients. Methods: All inborn extremely low birthweight (ELBW) treated after introduction were retrospectively studied (n = 196). The entire observational period was divided into four periods (periods 1–4)...
Very immature preterm infants are at risk of developing symptomatic or severe infection if cytomegalovirus is transmitted via breast milk. It still a matter debate whether human (HCMV) may lead to long-term sequelae.We hypothesized that and HCMV milk affects extremely very high rate.In 2012, untreated was fed low birth weight after parental informed consent obtained. We retrospectively analyzed data on born in 2012 between 22 24 weeks gestation.17 were IgG-seropositive mothers. 11 (65%)...
Objective It was the aim of our study to evaluate independent effect preterm prelabor rupture membranes (PPROM) as a cause delivery on mortality during primary hospital stay and significant morbidities in very-low-birth-weight (VLBW) infants < 32 weeks gestation. Design Observational, epidemiological design. Setting Population-based cohort, German Neonatal Network (GNN). Population 6102 VLBW were enrolled GNN from 2009-2012, n=4120 fulfilled criteria for analysis (< gestational weeks, no...
Objective To determine if survival rates of preterm infants receiving active perinatal care improve over time. Design The German Neonatal Network is a cohort study with birth weight <1500 g. All eligible are registered. We analysed data patients discharged between 2011 and 2016. Setting 43 level III neonatal intensive units (NICUs). Patients 8222 gestational age 22/0 28/6 weeks who received care. Interventions Participating NICUs were grouped according to their specific rate from 2013...