A5071478533- Birth, Development, and Health
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Pregnancy and preeclampsia studies
- Gestational Diabetes Research and Management
- Infant Development and Preterm Care
- Infant Health and Development
- Regulation of Appetite and Obesity
- Diet and metabolism studies
- Maternal Mental Health During Pregnancy and Postpartum
- Obesity, Physical Activity, Diet
- Growth Hormone and Insulin-like Growth Factors
- Nitric Oxide and Endothelin Effects
- Asthma and respiratory diseases
- Diet, Metabolism, and Disease
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Liver Disease Diagnosis and Treatment
- Cancer Risks and Factors
- Pancreatic function and diabetes
- Reproductive System and Pregnancy
- Fatty Acid Research and Health
- Bariatric Surgery and Outcomes
- Family and Patient Care in Intensive Care Units
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Metabolomics and Mass Spectrometry Studies
University Hospital Cologne
2014-2023
Klinik und Poliklinik für Kinder- und Jugendmedizin
2015-2023
University of Cologne
2014-2023
LVR-Klinik Köln
2023
German Sport University Cologne
2015
Abstract Aim To investigate the effects of 60 minutes delivery room skin‐to‐skin contact (DR‐SSC) compared with 5 visual (VC) on mother‐child interaction (MCI), salivary cortisol, maternal depression, stress and bonding at 6 months corrected age. Methods A single‐centre randomized controlled trial conducted in a German level III NICU. Eighty‐eight preterm infants (25‐32 weeks gestational age) were after initial stabilization to either DR‐SSC or VC. Forty‐five allocated DR‐SSC, 43 Results...
Abstract The C-terminal pro-fibrillin-1 propeptide asprosin is described as white adipose tissue derived hormone that stimulates rapid hepatic glucose release and activates hunger-promoting hypothalamic neurons. Numerous studies proposed correlations of levels with clinical parameters. However, the enormous variability reported serum plasma illustrates need for sensitive reliable detection methods in samples. Here we report on newly developed biochemical concentration several body fluids...
Exercise during pregnancy has beneficial effects on maternal and offspring’s health in humans mice. The underlying mechanisms remain unclear. This comparative study aimed to determine the long-term of an exercise program metabolism, weight gain, body composition changes hormones [insulin, leptin, brain-derived neurotrophic factor (BDNF)]. Pregnant women ( n =34) mouse dams =44) were subjected compared with matched controls (period I). Follow-up offspring was performed over 6 months humans,...
Abstract Childhood obesity is a risk factor for asthma, but the molecular mechanisms linking both remain elusive. Since leads to chronic low-grade inflammation and affects metabolic signaling we hypothesized that postnatal hyperalimentation (pHA) induced by maternal high-fat-diet during lactation early-onset dysregulates pulmonary adipocytokine/insulin signaling, resulting in programming of asthma-like disease adult mice. Offspring with pHA showed at day 21 (P21): (1) obesity, greater...
Purpose: Maternal obesity has emerged as an important risk factor for the development of metabolic disorders in offspring. The hypothalamus center energy homeostasis regulation is known to function based on complex neuronal networks that evolve during fetal and early postnatal maintain their plasticity into adulthood. Development hypothalamic feeding functional can be modulated by various cues, especially stages development. Here, we aimed at determining underlying molecular mechanisms...
Obesity during pregnancy is a known health risk for mother and child. Since obesity associated with increased inflammatory markers, our objectives were to determine interleukin-6 (IL-6) levels in obese mice examine the effect of IL-6 on placental endothelial cells. Placentas, blood, adipose tissue C57BL/6N mice, kept high fat diet before pregnancy, harvested at E15.5. Serum determined cell markers expression measured by qRT-PCR western blot. Immunostaining was used surface length densities...
Maternal obesity is associated with an increased risk of hepatic metabolic dysfunction for both mother and offspring targeted interventions to address this growing disease burden are urgently needed. This study investigates whether maternal exercise (ME) could reverse the detrimental effects in obese dams their while focusing on AMP-activated protein kinase (AMPK), representing a key regulator metabolism. In mouse model western-style-diet (WSD)-induced obesity, we established intervention...
Asprosin is a recently discovered hormone associated with obesity and diabetes mellitus. Little known about asprosin’s role during pregnancy, but contribution of asprosin to pregnancy complications resulting from maternal gestational mellitus (GDM) are conceivable. We assessed potential effects obesity, GDM other clinical parameters on fetal umbilical plasma concentrations placental expression. Our Cologne-Placenta-Cohort-Study comprises 247 female patients, which blood placentas were...
Objective One major risk factor for childhood overweight is maternal obesity. The underlying molecular mechanisms are ill‐defined, and effective prevention strategies missing. Methods Diet‐induced obese mouse dams were changed to standard chow during pregnancy lactation as an intervention against predisposition obesity metabolic sequelea in the offspring. Expression of adipokines TRPV4, a regulator adipose oxidative metabolism, inflammation, energy homeostasis, offspring's white tissue (WAT)...
Maternal obesity is known to predispose the offspring impaired glucose metabolism and associated with low-grade inflammation hypothalamic dysfunction. Because preventive approaches in this context are missing date, we aimed identify molecular mechanisms that affected by maternal exercise during pregnancy.Diet-induced obese mouse dams were divided into a sedentary (high-fat diet [HFD]) group an intervention (HFD-running [RUN]) group, which performed voluntary wheel running throughout...
Evidence suggests that maternal obesity (MO) can aggravate placental function causing severe pathologies during the perinatal window. However, molecular changes and mechanisms of dysfunction remain largely unknown. This work aimed to decipher structural alterations transfer zone associated with MO. To this end, mice were fed a high fat diet (HFD) induce before mating, pregnant dams sacrificed at E15.5 receive placentas for molecular, histological, ultrastructural analysis assess...
Abstract Maternal exercise (ME) during pregnancy has been shown to improve metabolic health in offspring and confers protection against the development of non-alcoholic fatty liver disease (NAFLD). However, its underlying mechanism are still poorly understood, it remains unclear whether protective effects on hepatic metabolism already seen early life. This study aimed at determining ME body composition NAFLD while focusing proteomic-based analysis energy developmental organ programming Under...
Objective Asprosin is a recently discovered hormone associated with obesity and diabetes mellitus. Little known about asprosin’s role during pregnancy, but contribution of asprosin to pregnancy complications resulting from maternal gestational mellitus (GDM) conceivable. We assessed the potential effects obesity, GDM other clinical parameters on fetal umbilical plasma concentrations placental expression. Design The Cologne-Placenta Cohort Study comprises 247 female patients, whom blood...
Sensi�ve paren�ng is characterized by observable parental behaviours in the interac�on with their children such as frequent, warm, and promptly reac�ons to children's signals.It facilitates secure atachment works a protec�ve factor for developmental behavioural problems both, preterm 1 term infants 2 .Improved mother child (MCI) at six months was recently reported 3 who had delivery room skin-to-skin contact (DR-SSC) one hour compared only visual (DR-VC).However, this improvement not...
Obesity and respiratory disorders are major health problems. is becoming an emerging epidemic with expected number of over 1 billion obese individuals worldwide by 2030, thus representing a growing socioeconomic burden. Simultaneously, obesity-related comorbidities, including diabetes as well heart chronic lung diseases, continuously on the rise. Although obesity has been associated increased risk for asthma exacerbations, worsening symptoms, poor control, functional role perturbed...
Childhood obesity is associated with renal diseases. Maternal a risk factor linked to increased adipocytokines and metabolic disorders in the offspring. Therefore, we studied impact of maternal on renal-intrinsic insulin adipocytokine signaling function structure. To induce obesity, female mice were fed high-fat diet (HFD) or standard (SD; control group) prior mating, during gestation, throughout lactation. A third group dams was HFD only lactation (HFD-Lac). After weaning at postnatal day...
Obesity and unhealthy nutrition are increasing affect women of childbearing age hence during pregnancy. Despite normal or even high birth weight, the offspring suffers from long-term metabolic risks. We hypothesized that fetal growth is disturbed different intrauterine phases. Underlying molecular events remain elusive. Female mice were fed either a standard diet (SD) high-fat (HFD) after weaning until mating Pregnant euthanized at gestational day (G)15.5 G18.5, fetuses placentas removed for...
The multitude of obesogenic diets used in rodent studies can hardly be overviewed. Since standardization is missing and assuming that individual compositions provoke effects, the choice quality, quantity combination diet ingredients seems to crucial for outcome interpretation obesity studies. Therefore, present study was conducted compare effects three commonly diets, mainly differing sugar fat content. Besides basic phenotypic metabolic characterization, one main aspect a comparative liver...
There is accumulating evidence for fetal programming of later kidney disease by maternal obesity or associated conditions. We performed a hypothesis-generating study to identify potentially underlying mechanisms. Female mice were randomly split in two groups and fed either standard diet (SD) high fat (HFD) from weaning until mating during pregnancy. Half the dams both treated with metformin ((M), 380 mg/kg), resulting four experimental (SD, SD-M, HFD, HFD-M). Caesarean section was on...
Ketamine is a widely used drug in pediatric anesthesia, and both neurotoxic neuroprotective effects have been associated with its use. There are only few studies to date which examined the of ketamine on neurons under hypoxic conditions, may lead severe brain damage poor neurocognitive outcomes neonates. In present study, cellular pathways neurogenesis, extracellular matrix homeostasis proliferation were <em>in vitro</em> hypoxia‑exposed neurons. Differentiated HT22 murine hippocampal...