A5000361581- Neonatal Respiratory Health Research
- Infant Development and Preterm Care
- Infant Nutrition and Health
- Neuroscience of respiration and sleep
- Congenital Diaphragmatic Hernia Studies
- Neonatal and fetal brain pathology
- Congenital Heart Disease Studies
- Cerebrospinal fluid and hydrocephalus
- Diet and metabolism studies
- Craniofacial Disorders and Treatments
- Neuroscience and Neuropharmacology Research
- Iron Metabolism and Disorders
- Esophageal and GI Pathology
- Renal and related cancers
- Hip disorders and treatments
- Eating Disorders and Behaviors
- Elbow and Forearm Trauma Treatment
- Fatty Acid Research and Health
- Multidisciplinary Science and Engineering Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Dysphagia Assessment and Management
- Experimental Learning in Engineering
- Hip and Femur Fractures
- Shoulder Injury and Treatment
- Intestinal Malrotation and Obstruction Disorders
University Hospital Cologne
2016-2025
University of Cologne
2006-2025
Klinik und Poliklinik für Kinder- und Jugendmedizin
2023-2024
Centrum für Integrierte Onkologie
2019
University of Cincinnati
2015
Boston Children's Hospital
2011
<i>Background:</i> Apnea and bradycardia of prematurity (ABP) are possible risks towards damage the developing brain. <i>Objectives:</i> To characterize influence neonatal factors on ABP to determine relationship neurodevelopmental outcome. <i>Methods:</i> was described in very low birth weight infants (n = 83) using frequency severity episodes with a clinical score considering heart rate, oxygenation, duration interventions performed during each episode....
<h3>Importance</h3> Rates of survival for infants born at the border viability are still low and vary considerably among neonatal intensive care units. <h3>Objective</h3> To determine whether higher rates better short-term outcomes 22 or 23 weeks’ gestation may be achieved by active prenatal postnatal care. <h3>Design, Setting, Participants</h3> Retrospective study 106 weeks a level III unit University Cologne Medical Centre in Cologne, Germany, between January 1, 2010, December 31, 2014....
Importance The inclusion of less invasive surfactant administration (LISA) in the care preterm infants has been found to be beneficial for respiratory outcomes. Recently, OPTIMIST trial higher mortality rates subgroup born at 25 26 weeks’ gestational age (GA) who received treatment while spontaneously breathing. Objective To analyze outcomes among LISA-exposed, highly vulnerable babies than 27 GA within large-scale observational cohort German Neonatal Network. Design, Setting, and...
Abstract The C-terminal pro-fibrillin-1 propeptide asprosin is described as white adipose tissue derived hormone that stimulates rapid hepatic glucose release and activates hunger-promoting hypothalamic neurons. Numerous studies proposed correlations of levels with clinical parameters. However, the enormous variability reported serum plasma illustrates need for sensitive reliable detection methods in samples. Here we report on newly developed biochemical concentration several body fluids...
The aim of this study was to investigate long-term bone development in children with cerebral palsy (CP) using longitudinal measurements total body less head mineral content (TBLH-BMC) and density (TBLH-BMD). A retrospective analysis performed on 109 CP who participated a rehabilitation programme from 2006 2018. Dual-energy X-ray absorptiometry (DXA) scans were at the beginning repeated as clinically indicated. used SITAR growth curve LMS method within GAMLSS model generate developmental...
For nasal application of neurotrophins and mesenchymal stem cells, successful delivery to the brain therapeutic effects are known from experimental data in animals. Human breast milk contains but gavage tube feeding preterm infants bypasses naso-oropharynx. This is a first exploration on additional neuromorphological outcome after severe neonatal injury. We present retrospective summary 31 very low birth weight with intraventricular hemorrhage °3/4 one third-level center. All were fed....
Abstract The aim of our study was to observe the temporal distribution serum N-terminal pro-brain natriuretic peptide (NT-proBNP) in premature infants ≤ 31 weeks gestational age (GA) during first life. NT-proBNP values 118 preterm born GA were determined week life, after 4 ± 1 and at a corrected 36 2 weeks. Infants divided into two groups: those without relevant complications with related prematurity. define exploratory reference values. Median level these 1896 ng/l ( n = 27, interquartile...
<b><i>Background:</i></b> Pulmonary hypertension (PH) affects 1 in 6 infants with a birthweight <1,000 g (extremely low birthweight; ELBW) and is frequently associated bronchopulmonary dysplasia (BPD). If untreated, the mortality rates of disease are high. <b><i>Objectives:</i></b> The aim this study was to characterize risk factors for PH ELBW describe timing onset by setting up screening program....
Human breast milk could be an important stem cell source for the development of newborn and preterm infants, but quantitative data on content in at various gestational stages are needed to determine clinical value as a cells. Breast also contains fat globules, lipid droplets different sizes, debris dead cells these components hamper flow cytometry analysis human samples.Here, we originally used standard protocols characterize populations failed discriminate between noncellular components. We...
Abstract The aim of this observational study was to investigate the influence different typical preterm diseases on NT-proBNP serum levels in early postnatal period life a infant. 118 infants born ≤ 31 weeks GA were determined at first week life, after 4 ± 1 and corrected gestational age 36 + 2 weeks. Relevant complications with possible values such as neonatal infection, hemodynamically significant PDA (hsPDA), pulmonary hypertension (early PH), intraventricular hemorrhage (IVH) evaluated;...
The olfactory bulb has a key role for nasal delivery of drugs to the brain by its access from mucosa and connection subventricular zone. aim this study was investigate neuromodulatory capacity human milk premature infants on bulb.Olfactory bulbs P1 mice were embedded in collagen I gel incubated with DMEM supplemented aqueous phase colostrum (Col) five mothers after very preterm birth, mature (Mat) same or without supplement (Ctrl). After 7 days, neurite outgrowth quantified. Proteome...
Ketamine is a widely used drug in pediatric anesthesia, and both neurotoxic neuroprotective effects have been associated with its use. There are only few studies to date which examined the of ketamine on neurons under hypoxic conditions, may lead severe brain damage poor neurocognitive outcomes neonates. In present study, cellular pathways neurogenesis, extracellular matrix homeostasis proliferation were <em>in vitro</em> hypoxia‑exposed neurons. Differentiated HT22 murine hippocampal...
The aim was to assess the results of primary anastomosis (PA) compared enterostomy (ES) in infants with spontaneous intestinal perforation (SIP) and a weight below 1000 g. Between 2014 2016, routinely carried out on extremely low birth (ELBW) patients SIP. From 2016 until 2019, all underwent without stoma formation. We outcome complications both groups. Forty-two median gestational age 24.3 weeks 640 g SIP were included. Thirty PA; ES performed 12 patients. Overall in-hospital mortality...
Abstract Our study was designed to assess the rates of exclusive breastfeeding (defined as direct breastfeeding) and use mother’s own milk (MOM) in preterm infants sick term at discharge identify potential influencing factors such gestational age, early colostrum, privacy. The conducted a German level III neonatal department. All admitted intensive care unit, pediatric intermediate low ward were included study. Infants recruited between March October 2015 (phase 1) April July 2016 2). Due an...
The creation of a primary anastomosis in newborns with oesophageal atresia and distal oesophageotracheal fistula (EA-DF) is technically challenging, especially small children. goal to approximate the fragile ends without suture disruption minimize mobilisation lower segment. We describe an alternative technique aiming at reducing tension on first sutures posterior wall.EA-DF was corrected 13 either by open (n = 11) or thoracoscopic 2) surgery using this technique.The based dorsal flap upper...
Hintergrund Eine intraventrikuläre Hämorrhagie führt zu einer veränderten Zusammensetzung von neuroinflammatorischen Mediatoren im Liquor. Der posthämorrhagische Hydrozephalus (PHH) Frühgeborenen (FG) als Komplikation intraventrikulären geht mit Inflammationsreaktion einher [1] [2]. In Vorbereitung auf die Untersuchung modulierender Faktoren des Profils für NAMU-Studie (Clinicaltrials.gov NCT4229693) untersuchten wir in diesem Pilotprojekt natürliche Veränderung der innerhalb ersten drei...