Ulrich Thomé
A5008142938- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Respiratory Support and Mechanisms
- Neuroscience of respiration and sleep
- Infant Development and Preterm Care
- Neonatal and fetal brain pathology
- Ion Transport and Channel Regulation
- Infant Nutrition and Health
- Neonatal Health and Biochemistry
- Cerebrospinal fluid and hydrocephalus
- Birth, Development, and Health
- Neonatal and Maternal Infections
- Congenital Heart Disease Studies
- Congenital Anomalies and Fetal Surgery
- Fetal and Pediatric Neurological Disorders
- Pregnancy and preeclampsia studies
- Cardiac Arrest and Resuscitation
- Central Venous Catheters and Hemodialysis
- Biomedical and Chemical Research
- Medical and Health Sciences Research
- Cystic Fibrosis Research Advances
- Breastfeeding Practices and Influences
- Traumatic Brain Injury and Neurovascular Disturbances
- Ion channel regulation and function
- Assisted Reproductive Technology and Twin Pregnancy
Leipzig University
2015-2025
University Hospital Leipzig
2016-2025
Klinik und Poliklinik für Kinder- und Jugendmedizin
2007-2023
Hamad Medical Corporation
2021
Children's Hospital
2021
Engineering Associates (United States)
2016
Universitätskinderklinik
2010
Universität Ulm
1994-2009
University Hospital Ulm
1994-2006
University of Alabama at Birmingham
1998-2003
Preeclampsia is a devastating complication of pregnancy. Soluble Fms-like tyrosine kinase-1 (sFlt-1) an antiangiogenic protein believed to mediate the signs and symptoms preeclampsia. We conducted open pilot study evaluate safety potential efficacy therapeutic apheresis with plasma-specific dextran sulfate column remove circulating sFlt-1 in 11 pregnant women (20–38 years age) very preterm preeclampsia (23–32 weeks gestation, systolic BP ≥140 mmHg or diastolic ≥90 mmHg, new onset...
<h3>Importance</h3> Red blood cell transfusions are commonly administered to infants weighing less than 1000 g at birth. Evidence-based transfusion thresholds have not been established. Previous studies suggested higher rates of cognitive impairment with restrictive thresholds. <h3>Objective</h3> To compare the effect liberal vs red strategies on death or disability. <h3>Design, Setting, and Participants</h3> Randomized clinical trial conducted in 36 level III/IV neonatal intensive care...
Importance The inclusion of less invasive surfactant administration (LISA) in the care preterm infants has been found to be beneficial for respiratory outcomes. Recently, OPTIMIST trial higher mortality rates subgroup born at 25 26 weeks’ gestational age (GA) who received treatment while spontaneously breathing. Objective To analyze outcomes among LISA-exposed, highly vulnerable babies than 27 GA within large-scale observational cohort German Neonatal Network. Design, Setting, and...
Abstract Background No results of controlled trials are available for any the few treatments offered to children with interstitial lung diseases (chILD). We evaluated hydroxychloroquine (HCQ) in a phase 2, prospective, multicentre, 1:1-randomized, double-blind, placebo-controlled, parallel-group/crossover trial. HCQ (START arm) or placebo were given 4 weeks. Then all subjects received another In STOP arm already taking randomized 12 weeks (= withdrawal HCQ). stopped treatment and observed...
Abstract Background Despite therapeutic hypothermia (TH) and neonatal intensive care, 45–50% of children affected by moderate-to-severe hypoxic-ischemic encephalopathy (HIE) die or suffer from long-term neurodevelopmental impairment. Additional neuroprotective therapies are sought, besides TH, to further improve the outcome infants. Allopurinol — a xanthine oxidase inhibitor reduced production oxygen radicals subsequent brain damage in pre-clinical preliminary human studies cerebral ischemia...
Ventilation with higher PaCO(2) goals may reduce lung injury and bronchopulmonary dysplasia (BPD). The effect be enhanced by using a goal than in previous trials.To determine the clinical benefits safety of for ventilated preterm infants.Preterm infants gestational age between 23 28 completed weeks receiving mechanical ventilation within 6 h birth were randomized to managed either target 55 65 mm Hg (7.3- 8.7 kPa, minimal ventilation) or 35 45 (4.7- 6.0 routine first 7 days life. primary...
Objectives To compare the effect of liberal versus restrictive transfusion strategies on proportion time (%time) spent with intermittent hypoxaemia (IH, ie, arterial haemoglobin oxygen saturation measured by pulse oximetry (SpO 2 ) <80% lasting ≥60 s) in ‘Effects Transfusion Thresholds Neurocognitive Outcome’ (ETTNO) population, and to investigate whether infants above-median exposure IH might benefit more from than those lower exposure. Design, setting, patients Secondary analysis all...
The CFTR Cl– channel controls salt and water transport across epithelial tissues. Previously, we showed that CFTR-mediated currents in the Xenopus oocyte expression system are inhibited by syntaxin 1A, a component of membrane trafficking machinery. This negative modulation function can be reversed soluble 1A peptides binding protein, Munc-18. In present study, determined whether is expressed native tissues normally express it modulates these Using immunoblotting immunofluorescence, observed...
Respiratory distress syndrome (RDS) is the most frequent pulmonary complication in preterm infants. RDS incidence differs between genders, which has been called male disadvantage. Besides maturation of surfactant system, Na+ transport driven alveolar fluid clearance crucial for prevention RDS. mediated by epithelial channel (ENaC) and Na,K-ATPase, therefore potential differences their expression or activity possibly contribute to gender imbalance observed Fetal distal lung (FDLE) cells rat...
Abstract Non-invasive cardiac output monitoring, via electrical biosensing technology (EBT), provides continuous, multi-parameter hemodynamic variable monitoring which may allow for timely identification of instability in some neonates, providing an opportunity early intervention that improve neonatal outcomes. EBT encompasses thoracic (TEBT) and whole body (WBEBT) methods. Despite the lack relative accuracy these technologies, as compared to transthoracic echocardiography, use technologies...
Importance Retinopathy of prematurity (ROP) is a major morbidity preterm infants causing visual impairment, including blindness, for which timely treatment vital and prevention key. Increasing evidence suggests that exposure to neonatal sepsis contributes ROP development. Objective To investigate the association between in 2 large-scale cohorts born at less than 29 weeks’ gestation. Design, Setting, Participants This retrospective cohort study was conducted using data from German Neonatal...