A5060104195- SARS-CoV-2 and COVID-19 Research
- COVID-19 Impact on Reproduction
- Retinopathy of Prematurity Studies
- Neonatal Respiratory Health Research
- Maternal Mental Health During Pregnancy and Postpartum
- Congenital Diaphragmatic Hernia Studies
- Infant Nutrition and Health
- Retinoids in leukemia and cellular processes
- COVID-19 Clinical Research Studies
- Neuroscience of respiration and sleep
- Renal and related cancers
- Monoclonal and Polyclonal Antibodies Research
- Pregnancy and Medication Impact
- Immunotherapy and Immune Responses
- Pregnancy and preeclampsia studies
- Ectopic Pregnancy Diagnosis and Management
- Breastfeeding Practices and Influences
- Pediatric Hepatobiliary Diseases and Treatments
- Viral Infections and Immunology Research
- Neonatal and Maternal Infections
- T-cell and B-cell Immunology
- vaccines and immunoinformatics approaches
- Airway Management and Intubation Techniques
- Congenital heart defects research
- Gynecological conditions and treatments
Universitäts Hautklinik Kiel
2023-2024
University Hospital Schleswig-Holstein
2020-2024
University of Lübeck
2020-2024
Klinik und Poliklinik für Kinder- und Jugendmedizin
2020-2024
Kiel University
2023
Charité - Universitätsmedizin Berlin
2013-2021
University Medical Center
2021
University Hospital and Clinics
2021
In light of the SARS-CoV-2 pandemic, protecting vulnerable groups has become a high priority. Persons at risk severe disease, for example, those receiving immunosuppressive therapies chronic inflammatory cdiseases (CIDs), are prioritised vaccination. However, data concerning generation protective antibody titres in immunosuppressed patients scarce. Additionally, mRNA vaccines represent new vaccine technology leading to increased insecurity especially with CID.Here we present first time, on...
Abstract Thousands of genetic variants in protein-coding genes have been linked to disease. However, the functional impact most is unknown as they occur within intrinsically disordered protein regions that poorly defined functions 1–3 . Intrinsically can mediate phase separation and formation biomolecular condensates, such nucleolus 4,5 This suggests mutations proteins may alter condensate properties function 6–8 Here we show a subset disease-associated separation, cause mispartitioning into...
Importance The inclusion of less invasive surfactant administration (LISA) in the care preterm infants has been found to be beneficial for respiratory outcomes. Recently, OPTIMIST trial higher mortality rates subgroup born at 25 26 weeks’ gestational age (GA) who received treatment while spontaneously breathing. Objective To analyze outcomes among LISA-exposed, highly vulnerable babies than 27 GA within large-scale observational cohort German Neonatal Network. Design, Setting, and...
Background The persistence of the SARS-CoV2 pandemic, partly due to appearance highly infectious variants, has made booster vaccinations necessary for vulnerable groups. Questions remain as which cohorts require boosters. However, there is a critical lack data on dynamics vaccine responses in patients with chronic inflammatory diseases (CID) undergoing immunosuppressive/disease modifying anti-rheumatic (DMARD) treatment. Here, we present first regarding decline vaccine-induced humoral immune...
Recently, it has been questioned whether vaccination of patients with inflammatory (auto)immune diseases under anti-tumor necrosis factor (TNF) treatment leads to impaired vaccine-induced immune responses and protection against breakthrough infections. However, the effects TNF blockade on short- long-term after repeated remain unclear. Vaccination studies have shown that initial short-term IgG antibodies (Abs) carry highly galactosylated sialylated Fc glycans, whilst Abs low levels...
Abstract The humoral immune response to severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) vaccination in patients with chronic inflammatory disease (CID) declines more rapidly tumor necrosis factor‐α (TNF‐α) inhibition. Furthermore, the efficacy of current vaccines against Omicron variants concern (VOC) including BA.2 is limited. Alterations within cell populations, changes IgG affinity, and ability neutralize a pre‐VOC strain virus were investigated these at‐risk patients. Serum...
Importance Retinopathy of prematurity (ROP) is a major morbidity preterm infants causing visual impairment, including blindness, for which timely treatment vital and prevention key. Increasing evidence suggests that exposure to neonatal sepsis contributes ROP development. Objective To investigate the association between in 2 large-scale cohorts born at less than 29 weeks’ gestation. Design, Setting, Participants This retrospective cohort study was conducted using data from German Neonatal...
Awareness of SARS-CoV-2 infection in pregnant women and the potential risk for their neonates is increasing. The aim this study was to examine immune status affected evaluate dynamics placental antibody transfer.
Abstract The analysis of CRONOS data for this article presents the infection prevalence among parturients and subsequent changes in obstetric management over time Germany. 2,184 women with peripartum SARS-CoV-2 (<14d before birth) were included. Monthly period was calculated using number affected on registry relative to total monthly births each hospital from March 2020 May 2022 compared RKI data. Trends related based severity illness. By June 2021, population shows a discretely higher...
Milk curd obstruction as a cause of intestinal has been known since 1959, but nearly disappeared. However, in recent years it experienced revival small premature infants.The aim this study was to evaluate the clinical characteristics milk (lactobezoar) preterm infants.Data infants with cared for at large tertiary neonatal intensive care unit between 2012 and 2016 were retrieved from electronic registry paper records.A total 10 (2 girls, 8 boys) identified: median birth weight 595 g (range...
ABSTRACT Fetal cardiac tumors are a rare finding in prenatal ultrasonography. Most of them rhabdomyoma, which thought to be pathognomonic for tuberous sclerosis complex. We present an infant with prenatally diagnosed rhabdomyoma (CR), who was found suffer from Beckwith‐Wiedemann syndrome (BWS). This congenital overgrowth is characterized by macrosomia, macroglossia, omphalocele, hypoglycemia, and hemihypertrophy. BWS patients have increased risk formation benign malignant tumors, typically...
Zusammenfassung Das neuartige Coronavirus SARS-CoV-2 hat sich zu einer Pandemie entwickelt, in der es noch viele Unbekannte gibt. Die Modalitäten Übertragung, unterschiedlichen Symptome und Ausprägungen sowie Begleiterscheinung Erkrankung sind unzureichend charakterisiert. Gerade Patientengruppen besonderen Situationen wie Schwangere Neugeborene müssen dabei separat betrachtet werden. bisherige Wissen Schwangerschaft, Geburt den ersten Lebenstagen ist aufgrund spärlichen Datenlage von...
Abstract In orally fed preterm infants, poor weight gain may be linked to low fecal pancreatic elastase-1 (FPE-1) activity, indicative of exocrine insufficiency. The objective this study was the retrospective assessment effect exogenous digestive enzyme replacement by gavage in infants with growth failure and FPE-1 (<200 μg/g). We analyzed relative baseline caloric intake during 14-day periods before after institution containing 6000 U lipase 240 protease kg −1 d . Among 46 132 < 1250g...
Abstract Background Medical simulation training requires realistic simulators with high fidelity. This prospective multi-center study investigated anatomic precision, physiologic characteristics, and fidelity of four commercially available very low birth weight infant simulators. Methods We measured airway angles distances in the Premature AirwayPaul (SIMCharacters), Anne (Laerdal Medical), Premie HAL S2209 (Gaumard), Preterm Baby (Lifecast Body Simulation) using computer tomography compared...
<b><i>Background: </i></b>The relative dose response (RDR) test, which quantifies the increase in serum retinol after vitamin A administration, is a qualitative measure of liver stores. Particularly preterm infants, feasibility RDR test involving blood critically dependent on small sample volumes. <b><i>Objectives:</i></b> This study aimed to assess whether calculated with retinol-binding protein 4 (RBP4) might be substitute for classical...
Abstract Background The extensive use of antibiotics is reflected by an increasing prevalence infections with multidrug-resistant bacteria, including third-generation cephalosporin-resistant bacteria (3GCRB). For neonatal intensive care units screening and enhanced barrier precautions are recommended to control the spread Gram-negative while evidence for efficacy remains scarce in a non-outbreak setting. Objective To determine impact program maternal 3GCRB colonization effects contact cohort...
Abstract SARS-CoV-2 infection and COVID-19 disease are thought to have an impact on breastfeeding rate – besides other known peripartal issues. Data of the national CRONOS registry regarding behavior in 6,746 women was analyzed time window between maternal delivery. In addition, influencing factors like predominant viral variant, severity, gestational age at delivery were taken into account. Our data suggest that within variables analyzed, case acute (<14 days before birth), improved with...
Abstract Introduction The management of a pregnancy in bicornuate uterus is particularly challenging. A rare occurrence and twin even more rare. These pregnancies call for intensive diagnostic investigation interdisciplinary care. Case presentation We report on 27-year-old European woman patient (gravida I, para 0) with simultaneous each cavity bicollis after embryo transfer. condition was confirmed by hysteroscopy laparoscopy. Several unsuccessful vitro fertilization (IVF) attempts had been...