A5084661933- Neonatal Respiratory Health Research
- Neuroscience of respiration and sleep
- Infant Nutrition and Health
- Congenital Diaphragmatic Hernia Studies
- Infant Development and Preterm Care
- Neonatal and Maternal Infections
- Neonatal and fetal brain pathology
- Preterm Birth and Chorioamnionitis
- Respiratory Support and Mechanisms
- Respiratory viral infections research
- Child Nutrition and Water Access
- Retinopathy of Prematurity Studies
- Immune responses and vaccinations
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Complement system in diseases
- Tracheal and airway disorders
- Airway Management and Intubation Techniques
- Malaria Research and Control
- Blood disorders and treatments
- Neonatal Health and Biochemistry
- Birth, Development, and Health
- Mosquito-borne diseases and control
- Cytomegalovirus and herpesvirus research
- Immune Response and Inflammation
- Chemotherapy-related skin toxicity
University of Münster
2023-2025
University Hospital Münster
2023-2025
Klinik und Poliklinik für Kinder- und Jugendmedizin
2023-2025
University of Lübeck
2016-2023
Universitäres Kinderwunschzentrum Lübeck
2023
University Hospital Schleswig-Holstein
2017-2022
Witten/Herdecke University
2013
University of Tübingen
2010-2012
Albert Schweitzer Hospital
2010
In a large cohort study of the German Neonatal Network (GNN) we aimed to evaluate whether less invasive surfactant administration (LISA) strategy is associated with complications preterm birth. Within observational period n = 7533 very-low-birth-weight infants (VLBWI) gestational age 22 0/7 28 6/7 weeks were enrolled in GNN; 1214 VLBWI never received surfactant, 2624 treated according LISA procedure, 3695 had via endotracheal tube (ETT). was reduced risk for adverse outcome measures...
Importance The inclusion of less invasive surfactant administration (LISA) in the care preterm infants has been found to be beneficial for respiratory outcomes. Recently, OPTIMIST trial higher mortality rates subgroup born at 25 26 weeks’ gestational age (GA) who received treatment while spontaneously breathing. Objective To analyze outcomes among LISA-exposed, highly vulnerable babies than 27 GA within large-scale observational cohort German Neonatal Network. Design, Setting, and...
Antimicrobial peptides (AMPs) are crucial components of the innate immune system in various organisms, including humans. Beyond their direct antimicrobial effects, AMPs play essential roles physiological processes. They induce angiogenesis, promote wound healing, modulate responses, and serve as chemoattractants for cells. regulate microbiome combat microbial infections on skin, lungs, gastrointestinal tract. Produced response to signals, help maintain a balanced community provide first line...
Objective To determine if survival rates of preterm infants receiving active perinatal care improve over time. Design The German Neonatal Network is a cohort study with birth weight <1500 g. All eligible are registered. We analysed data patients discharged between 2011 and 2016. Setting 43 level III neonatal intensive units (NICUs). Patients 8222 gestational age 22/0 28/6 weeks who received care. Interventions Participating NICUs were grouped according to their specific rate from 2013...
In 2011 Escherichia coli O104:H4 caused an outbreak with >800 cases of hemolytic uremic syndrome (HUS) in Germany, including 90 children. Data on the intermediate outcome children after HUS due to E. have been lacking.Follow-up data were gathered retrospectively from medical records patients who had included German Pediatric Registry during outbreak.Seventy-two 89 (81%) a median follow-up 3.0 (0.9-4.7) years. Hypertension and proteinuria present 19% 28% these patients, respectively. Of 4...
Gastrointestinal complications during the neonatal period, i.e. necrotizing enterocolitis (NEC) and spontaneous intestinal perforation (SIP), are associated with adverse short-term outcome in very-low-birthweight infants (VLBWI, <1500 g birth weight). However, little is known about neurological of survivors at school age. We analysed data 2241 followed-up age 6 years. To determine effect NEC SIP on cognitive consideration other important confounding factors, we used multivariable logistic...
Aim: To analyze short term outcomes of very low birth weight infants (VLBWI) born preterm after maternal preeclampsia and HELLP syndrome within the German Neonatal Network. Methods: The Network is a large population-based cohort study enrolling VLBWI since 2009. Two thousand six hundred fifty two below 32 weeks gestation or 13,383 prematurely for other causes between 2009 2018 were included in our analysis. Descriptive statistics multinomial regression models including performed short-term...
Aim The aim of the study is to evaluate influence timing antenatal steroids (ANSs) on neonatal outcome very low birth weight infants (VLBWI) born before 30 weeks gestation in German Neonatal Network. Methods Network a large population-based cohort enrolling VLBWIs since 2009. We included 672 neonates, who were between January 1, 2009 and December 31, 2019 our analysis 10 selected centers. Infants divided into four subgroups based interval first steroid administration preterm birth: (I) two...
Background. We compared a conventional empirically derived regimen with simplified for parenteral artesunate in severe malaria. Methods. This was randomized, double-blind, placebo-controlled comparison to assess the noninferiority of 3-dose (given at 0, 24, and 48 hours) 5-dose intravenous 12, 48, 72 African children Plasmodium falciparum malaria prespecified delta 0.2. The total dose each group 12 mg/kg. primary end point proportion clearing ≥99% their admission parasitemia 24 hours. Safety...
Importance Retinopathy of prematurity (ROP) is a major morbidity preterm infants causing visual impairment, including blindness, for which timely treatment vital and prevention key. Increasing evidence suggests that exposure to neonatal sepsis contributes ROP development. Objective To investigate the association between in 2 large-scale cohorts born at less than 29 weeks’ gestation. Design, Setting, Participants This retrospective cohort study was conducted using data from German Neonatal...
Very-low-birth-weight infants (VLBWIs; birth weight < 1500 g) are at an increased risk of complicated influenza infection, which frequently includes pneumonia, encephalitis or even death. Data on immunization and its outcome in VLBWIs scarce. This study aimed to provide epidemiological data for German hypothesized that would protect from infection-mediated neurodevelopmental impairment preserves lung function early school age. In this observational population-based Neonatal Network (GNN)...
Introduction Delayed enteral nutrition is associated with a higher risk for adverse outcomes in extremely preterm infants. Limited evidence exists on therapeutic options to support meconium evacuation and increase gastrointestinal motility. The aim of this study was determine the effect macrogol feeding tolerance microbiome establishment infants < 27 weeks gestation. Methods We investigated impact early administration two observational cohort studies: multi-center German-Neonatal-Network...
Summary Clinical management of congenital hyperinsulinism (CHI) remains a significant challenge due to its complex pathophysiology and the limitations available therapies. Dasiglucagon, synthetic glucagon analog, represents novel approach managing CHI, particularly in patients where conventional therapies fail. This report discusses rare case prolonged continuous subcutaneous dasiglucagon use neonate with CHI. Despite initial stabilization glycemic levels, patient developed necrolytic...
Vancomycin is an extensively used anti-infective drug in neonatal ICUs. However, exposure-toxicity relationships have not been clearly defined.To evaluate the risk profile for hearing deficits vancomycin-exposed very-low-birthweight infants (VLBWI).In a large cohort study of German Neonatal Network (GNN; n = 16 967 VLBWI) we assessed association vancomycin treatment and pathological tests at discharge 5 year follow-up. We performed audits on exposure, levels, dose adjustments exposure to...
Studies on the influence of mannose-binding lectin (MBL) deficiency infection susceptibility in preterm infants have yielded controversial results. We investigated association genotype-based MBL levels with outcome very-low-birth weight (VLBWI).We genotyped 3 genetic variants MBL2 (rs1800450, rs1800451, rs5030737) 6878 VLBWI. plasma were categorized as normal (wild type, A/A), low (heterozygotes, A/O) or undetectable (homozygotes, O/O). Primary was effect blood-culture proven and clinical...
Objective: To evaluate the nutrition-related effects of prophylactic Lactobacillus acidophilus/Bifidobacterium infantis probiotics on outcomes preterm infants <29 weeks gestation that receive human milk and/or formula nutrition. We hypothesize human-milk-fed benefit from in terms sepsis prevention and growth.We performed an observational study German Neonatal Network (GNN) over a period six years, between 1 January, 2013 31 December, 2018. Prophylactic probiotic use L. acidophilus/B. was...
Abstract Background In 2013 German infection surveillance guidelines recommended weekly colonization screening for multidrug-resistant (MDRO) or highly epidemic organisms neonatal intensive care units (NICUs) and extended hygiene measures based on results. It remains a matter of debate whether is worth the effort. We therefore aimed to evaluate sepsis related outcomes before after guideline update. Methods The Neonatal Network (GNN) prospective cohort study including data from extremely...
Abstract Objective We hypothesized that previously healthy infants < 90 days of age with late-onset sepsis (LOS) have disturbances the gut microbiome yet undefined specific immunological patterns. Methods performed a prospective single-center convenience sample study between January 2019 and July 2021 in case-control design. Routine diagnostics included conventional cultures (blood, cerebrospinal fluid, urine), PCRs inflammatory markers aged clinical LOS. additionally analyzed blood...
To establish reference intervals for major haematological and biochemical parameters in Gabonese infants children.The sample population consisted of 226 healthy (4-9 weeks age) 185 children (18-60 months age). Basic red cell as well total differential white blood counts were performed. Clinical chemistry glutamate-pyruvic transaminase creatinine, bilirubin was measured children. Statistical analysis based on the guidelines Laboratory Standards Institute. Nonparametric methods used to...