A5033520292- Neonatal Respiratory Health Research
- Infant Development and Preterm Care
- Neonatal and fetal brain pathology
- Neuroscience of respiration and sleep
- Neonatal Health and Biochemistry
- Congenital Diaphragmatic Hernia Studies
- Hemoglobinopathies and Related Disorders
- Child and Adolescent Health
- Birth, Development, and Health
- Infant Nutrition and Health
- Asthma and respiratory diseases
- Blood transfusion and management
- Retinopathy of Prematurity Studies
- Erythropoietin and Anemia Treatment
- T-cell and B-cell Immunology
- Pediatric Pain Management Techniques
- Metabolism and Genetic Disorders
- COVID-19 Impact on Reproduction
- Pregnancy and preeclampsia studies
- Pediatric Urology and Nephrology Studies
- Immune Cell Function and Interaction
- Allergic Rhinitis and Sensitization
- Family and Patient Care in Intensive Care Units
- Congenital Heart Disease Studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
Philipps University of Marburg
2016-2025
Universitätsklinikum Gießen und Marburg
2006-2025
Klinik und Poliklinik für Kinder- und Jugendmedizin
2010-2023
Universidad CES
2023
Children's Hospital
2018-2020
Karolinska University Hospital
2017
Inserm
2017
Université Paris Cité
2017
Sorbonne Paris Cité
2017
Hvidovre Hospital
2017
Sequence analysis of immunoglobulin (Ig) heavy and light chain transcripts can refine categorization B cell subpopulations shed on the selective forces that act during immune responses or dysregulation, such as autoimmunity, allergy, malignancy. High-throughput sequencing yields Ig transcript collections unprecedented size. The authoritative web-based IMGT/HighV-QUEST program is capable analyzing large provides annotated output files to describe many key properties transcripts. However,...
<h3>Importance</h3> Red blood cell transfusions are commonly administered to infants weighing less than 1000 g at birth. Evidence-based transfusion thresholds have not been established. Previous studies suggested higher rates of cognitive impairment with restrictive thresholds. <h3>Objective</h3> To compare the effect liberal vs red strategies on death or disability. <h3>Design, Setting, and Participants</h3> Randomized clinical trial conducted in 36 level III/IV neonatal intensive care...
Anemia of prematurity is characterized by low reticulocyte counts and inadequate erythropoietin response, for which many very-low-birth-weight infants receive multiple blood transfusions. We investigated whether early treatment such with recombinant human would reduce their need
<b>Objectives</b> To evaluate the implementation of four high evidence practices for care very preterm infants to assess their use and impact in routine clinical practice whether they constitute a driver reducing mortality neonatal morbidity. <b>Design</b> Prospective multinational population based observational study. <b>Setting</b> 19 regions from 11 European countries covering 850 000 annual births participating EPICE (Effective Perinatal Intensive Care Europe births)...
<h3>Importance</h3> Administration-to-birth intervals of antenatal corticosteroids (ANS) vary. The significance this variation is unclear. Specifically, to our knowledge, the shortest effective administration-to-birth interval unknown. <h3>Objective</h3> To explore associations between ANS and survival morbidity among very preterm infants. <h3>Design, Setting, Participants</h3> Effective Perinatal Intensive Care in Europe (EPICE) study, a population-based prospective cohort gathered data...
The Wilms' tumor suppressor gene (WT1) is one of the major regulators early gonadal and kidney development. WT1 mutations have been identified in 46,XY disorders sex development (DSD) with associated disease few isolated forms DSD.The objective study was evaluation different phenotypes DSD clinical consequences.The design was: 1) sequencing 210 patients from German network, consisting 150 males severe hypospadias (70 without cryptorchidism, 80 at least cryptorchid testis), 10 vanishing...
Objective To investigate the variation in severe neonatal morbidity among very preterm (VPT) infants across European regions and whether rates are higher with low compared high mortality rates. Design Area-based cohort study of all births before 32 weeks gestational age. Setting 16 11 countries 2011/2012. Patients Survivors to discharge from care (n=6422). Main outcome measures Severe was defined as intraventricular haemorrhage grades III IV, cystic periventricular leukomalacia, surgical...
Abstract Objectives We aimed to determine the frequency of SARS-CoV-2 positivity in newborns born mothers with peripartum infection a German cohort, identify potential risk factors associated neonatal infection, and present short-term outcomes vertical transmission SARS-CoV-2. Methods Data on women occurring anytime during their pregnancy was gathered prospectively within CRONOS registry. From April 2020 February 2023 total 8,540 had been registered. The timing probability mother-to-child...
Michael Obladen, Rolf Maier, Hugo Segerer' E. Ludwig Grauel, Barbara M. Holland, Graham Stewart, Gerhard Jorch, Heike Rabe, Otwin Linderkamp, H. G. Hoffmann, Frieda Houghton, Zuzana Herrmann, Paul Scigalla, Charles War drop Department of Neonatology, University Children's Hospital, Free University, Berlin, FRG; Charite Humboldt G D R ; Paediatrics, Queen Mother's Glasgow, UK; d Munster, ' Heidelberg, 'Clinical Research Department, MCP Pharmaceuticals, Livingston, Boehringer Mannheim GmbH,...
This study assessed the prevalence of small for gestational age (SGA) among very preterm (VPT) infants using national and European intrauterine references.We generated country-specific common growth references 11 countries, according to Gardosi's approach Hadlock's foetal model, data on birthweights by sex. These were applied Effective Perinatal Intensive Care in Europe (EPICE) cohort, which comprised 7766 live VPT births without severe congenital anomalies under 32 weeks gestation...
To compare duration and changes over time in length of hospital stay for very preterm extremely infants 10 European regions.Two area-based cohort studies from the same regions 2003 2011/2012.Ten nine countries.Infants born between 22 + 0 31 6 weeks gestational age surviving to discharge (Models Organising Access Intensive Care Very Preterm Births 2003, n = 4,011 Effective Perinatal Europe 2011/2012, 4,336).Observational study, no intervention.Maternal infant characteristics were abstracted...
To investigate whether extrauterine growth restriction (EUGR) during the neonatal hospitalisation by sex among extremely preterm (EPT) infants is associated with cerebral palsy (CP) and cognitive motor abilities at 5 years of age.Population-based cohort births <28 weeks gestation data from obstetric records parental questionnaires clinical assessments age.11 European countries.957 EPT born in 2011-2012.EUGR discharge unit was defined as (1) difference between Z-scores birth <-2 SD severe, -2...
Infants in the neonatal intensive care unit are regularly exposed to plasticizer di‐(2‐ethylhexyl)‐phthalate (DEHP) following exchange transfusion or extracorporeal membrane oxygenation. Whether such exposure leads increased morbidity is not known, although elevated levels of DEHP have been associated with necrotizing enterocolitis and cholestasis. The hypothesis that infants undergoing toxic presumed metabolite 2‐ethylhexanoic acid (EHXA) was tested by measuring serum 16 newborn...
After birth, contact to environmental Ags induces the production of IgA, which represents a first line defense for neonate. We sought characterize maturation repertoire IgA H chain transcripts in circulating blood B cells during human ontogeny. found that were present cord as early 27 wk gestation and restrictions primary Ab (IgM) persisted repertoire. Thus, harboring more "mature" V(H) regions not preferred class switch IgA. Preterm term neonates expressed unique repertoire, was...
Stillbirth and in-hospital mortality rates associated with very preterm births (VPT) vary widely across Europe. International comparisons are complicated by a lack of standardized data collection differences in definitions, registration, reporting. This study aims to determine what proportion the variation stillbirth VPT persists after adjusting for population demographics, case-mix, timing death.Standardized geographically defined prospective cohort VPTs (22+0-31+6 weeks gestation) 16...
The Effective Perinatal Intensive Care in Europe (EPICE) cohort includes all births between 22 + 0 and 31 + 6 weeks of gestation 2011/12 19 regions 11 European countries. This was set up to investigate the use evidence-based interventions for prenatal postnatal care infants born very preterm (VPT) explore associations their health developmental outcomes. first phase, ‘Effective perinatal intensive Europe’ focused on obstetric neonatal before around time birth during hospitalization period,...
Objective Extrauterine growth restriction (EUGR) among very preterm infants is related to poor neurodevelopment, but lack of consensus on EUGR measurement constrains international research. Our aim was compare prevalence in a European cohort using commonly used measures. Design Population-based observational study. Setting 19 regions 11 countries. Patients 6792 born before 32 weeks’ gestational age (GA) surviving discharge. Main outcome measures We investigated two based discharge-weight...