A5102877616- Neonatal Respiratory Health Research
- Neuroscience of respiration and sleep
- Infant Nutrition and Health
- Congenital Diaphragmatic Hernia Studies
- Infant Development and Preterm Care
- Preterm Birth and Chorioamnionitis
- Neonatal and Maternal Infections
- Neonatal and fetal brain pathology
- Respiratory viral infections research
- Pregnancy-related medical research
- Respiratory Support and Mechanisms
- Immune responses and vaccinations
- Retinopathy of Prematurity Studies
- Pediatric health and respiratory diseases
- Child Abuse and Related Trauma
- Birth, Development, and Health
- Homicide, Infanticide, and Child Abuse
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Child Nutrition and Water Access
- Erythrocyte Function and Pathophysiology
- Clinical Nutrition and Gastroenterology
- Infant Health and Development
- Salivary Gland Tumors Diagnosis and Treatment
- Parvovirus B19 Infection Studies
- Breastfeeding Practices and Influences
University of Lübeck
2015-2025
University Hospital Schleswig-Holstein
2014-2024
Universitäres Kinderwunschzentrum Lübeck
2014-2023
University Children’s Hospital Basel
2014
Klinik und Poliklinik für Kinder- und Jugendmedizin
2014
University Hospital of Bern
2014
McMaster University
2014
Universitätskinderklinik
2014
University of Bristol
2014
In a large cohort study of the German Neonatal Network (GNN) we aimed to evaluate whether less invasive surfactant administration (LISA) strategy is associated with complications preterm birth. Within observational period n = 7533 very-low-birth-weight infants (VLBWI) gestational age 22 0/7 28 6/7 weeks were enrolled in GNN; 1214 VLBWI never received surfactant, 2624 treated according LISA procedure, 3695 had via endotracheal tube (ETT). was reduced risk for adverse outcome measures...
Importance The inclusion of less invasive surfactant administration (LISA) in the care preterm infants has been found to be beneficial for respiratory outcomes. Recently, OPTIMIST trial higher mortality rates subgroup born at 25 26 weeks’ gestational age (GA) who received treatment while spontaneously breathing. Objective To analyze outcomes among LISA-exposed, highly vulnerable babies than 27 GA within large-scale observational cohort German Neonatal Network. Design, Setting, and...
Objective It was the aim of our study to evaluate independent effect preterm prelabor rupture membranes (PPROM) as a cause delivery on mortality during primary hospital stay and significant morbidities in very-low-birth-weight (VLBW) infants < 32 weeks gestation. Design Observational, epidemiological design. Setting Population-based cohort, German Neonatal Network (GNN). Population 6102 VLBW were enrolled GNN from 2009-2012, n=4120 fulfilled criteria for analysis (< gestational weeks, no...
Very-low-birth-weight infants (VLBWIs; birth weight < 1500 g) are at an increased risk of complicated influenza infection, which frequently includes pneumonia, encephalitis or even death. Data on immunization and its outcome in VLBWIs scarce. This study aimed to provide epidemiological data for German hypothesized that would protect from infection-mediated neurodevelopmental impairment preserves lung function early school age. In this observational population-based Neonatal Network (GNN)...
Prematurely born individuals are usually of low or normal weight in childhood; adulthood, however, their probability being overweight is twice that persons at full term. There not yet any way to predict the development premature babies. A polygenic BMI score (BMI = body-mass index), calculated from often very small individual effects more than 2 million genetic variants, was recently described for adults. We studied possible association this with course babies over time, infancy up age 10-14...
Introduction Delayed enteral nutrition is associated with a higher risk for adverse outcomes in extremely preterm infants. Limited evidence exists on therapeutic options to support meconium evacuation and increase gastrointestinal motility. The aim of this study was determine the effect macrogol feeding tolerance microbiome establishment infants < 27 weeks gestation. Methods We investigated impact early administration two observational cohort studies: multi-center German-Neonatal-Network...
Abstract Background To evaluate the use and effect of cervical stitch cerclage, pessary, progesterone on pregnancy outcome in mothers very low birth weight infants (VLBWI) born<32 weeks gestation German Neonatal Network (GNN). Methods The GNN is a population-based cohort study enrolling VLBWI since 2009. We included 575 neonates from 424 into our analysis, who were born between 2015 2019, after prenatal intervention with or combination 20/0 to 25/0 prevent preterm birth. Median...
Objective: To evaluate the nutrition-related effects of prophylactic Lactobacillus acidophilus/Bifidobacterium infantis probiotics on outcomes preterm infants <29 weeks gestation that receive human milk and/or formula nutrition. We hypothesize human-milk-fed benefit from in terms sepsis prevention and growth.We performed an observational study German Neonatal Network (GNN) over a period six years, between 1 January, 2013 31 December, 2018. Prophylactic probiotic use L. acidophilus/B. was...
Abstract Aim To determine the regional cerebral tissue oxygenation saturation (rc SO 2 ) in a group of infants requiring less invasive surfactant administration ( LISA as compared to with continuous positive airway pressure CPAP only. Methods In preterm gestational age 26 0/7‐31 6/7 weeks, we conducted an observational study using near‐infrared spectroscopy NIRS first 120 hours life. Results We analysed data 22 who never received ), had and 6 via endotracheal tube ETT ). Four both...
This study is aimed at detecting the rate of untimely immunization in a large cohort extremely low gestational age neonates (ELGANs) German Neonatal Network (GNN) and addressing risk factors for delayed vaccination associated long-term consequences. We performed an observational GNN between 1st January 2010 31st December 2019. The status hexavalent pneumococcal was evaluated n = 8401 preterm infants <29 weeks gestation. Univariate analysis logistic/linear regression models were used to...
BackgroundPrematurity and infection with respiratory syncytial virus (RSV) are major risk factors for impaired lung function beyond the neonatal period.Research QuestionWhat long-term effects of palivizumab immunoprophylaxis in first year life on frequency bronchitis episodes 5- to 6-year-old preterm infants?Study Design MethodsPreterm infants a birth weight < 1,500 g (very low-birth [VLBWIs]) were enrolled German Neonatal Network cohort study between 2009 2016. Children examined by single...
Antimicrobial polypeptides (APPs) are part of the innate immune system, but their specific role in context preterm birth is not yet understood. The aim this investigation was to determine systemic expression APPs, i.e., lactoferrin (LF) and human neutrophil protein (HNP) 1-3 infants period highest vulnerability for infection correlate these biomarkers with short-term outcome. We therefore conducted a prospective two-center study including plasma samples 278 78 corresponding mothers. APP...
Serum lactate levels are used as biomarkers for perinatal asphyxia, while their value outcome prediction in preterm infants is uncertain. It was the aim of this observational study to determine association first postnatal serum-lactate on day 1 life and short-term less than 29 gestational weeks. We analysed data a population-based cohort German Neonatal Network (GNN) with available enrolled at 22-28 weeks age (GA) between 1st April 2009 31st December 2020. hypothesized that high measured...
Zusammenfassung: Der nicht-immunologische Hydrops fetalis ist das Symptom verschiedenster Grunderkrankungen. Häufige Ursachen sind kardiovaskulären Erkrankungen, chromosomalen Defekte oder fetalen Anämien, seltener dagegen Stoffwechselrkrankungen, wie die infantile Sialinsäurespeicherkrankheit.
Background: Amniotic infection syndrome (AIS) with perinatal inflammation may increase the susceptibility to intraventricular hemorrhage (IVH) in preterm infants. Given its anti-inflammatory and ductus arteriosus constricting capacities, we hypothesized that prophylactic administration of indomethacin reduces incidence, severity, consequences IVH context inflammation. Methods: We evaluated data infants born between 2009 2020 22 + 0–25+6 weeks gestation from 68 German Neonatal Network...
Einleitung Extreme Unreife, die Bronchopulmonale Dysplasie und pulmonale Infektionen mit dem Respiratory-Syncytial-Virus (RSV) gehören zu den Hauptrisikofaktoren für eine langfristige Beeinträchtigung der Lungenfunktion bei Frühgeborenen einem Geburtsgewicht < 1500g (VLBWI, very-low-birth-weight infants). Aktuelle Leitlinien empfehlen saisonale Impfung Palivizumab hohem Risiko chronische Lungenerkrankungen. Da Daten aus klinischen Studien fehlen, ist bislang jedoch unklar, ob...
Hintergrund Die Sepsis ist die zweithäufigste Todesursache bei Frühgeborenen. Für eine Reihe von Infektionskrankheiten sind genetische Faktoren beschrieben, wie z.B. der Zusammenhang Blutgruppe A mit schweren Verläufen einer SARS-CoV2 Infektion [1]. Bei Frühgeborenen AB höheren Rate an nekrotisierender Enterokolitis assoziiert [2], auch für das fast zeitgleiche Auftreten Gruppe-B- Streptokokkeninfektionen frühgeborenen Zwillingen werden Einflüsse postuliert [3], es liegen bislang aber keine...
Hintergrund Infektionen gehören zu den häufigen Komplikationen bei Frühgeborenen mit einem Gestationsalter unter 29 Wochen (extermely-low-gestational-age neonates, ELGANs). Auch nach Entlassung aus dem primären stationären Aufenthalt kennzeichnet die Kinder eine erhöhte Vulnerabilität, insbesondere gegenüber infektiösen Atemwegserkrankungen. Impfungen gelten als effektive und sichere Präventionsmaßnahme. Neben Schutz vor impfpräventablen Krankheiten werden unspezifisch trainierende Effekte...
Ein weniger invasives Beatmungskonzept einschließlich Surfactantgabe via LISA-Verfahren begünstigt das Outcome bei Frühgeborenen < 29 Schwangerschaftswochen (SSW). Für eine zukünftig möglichst individualisierte Versorgung ist die Identifikation von Risikofaktoren für ein "LISA-Versagen", d.h. Notwendigkeit der invasiven Beatmung innerhalb ersten 72 Lebensstunden, sehr bedeutsam.