A5063775699- Neonatal Respiratory Health Research
- Neuroscience of respiration and sleep
- Neonatal and fetal brain pathology
- Infant Development and Preterm Care
- Congenital Diaphragmatic Hernia Studies
- Preterm Birth and Chorioamnionitis
- Respiratory Support and Mechanisms
- Congenital Heart Disease Studies
- Retinopathy of Prematurity Studies
- Child and Adolescent Health
- Hemodynamic Monitoring and Therapy
- Non-Invasive Vital Sign Monitoring
- Pregnancy-related medical research
- Neonatal and Maternal Infections
- Infant Nutrition and Health
- Optical Imaging and Spectroscopy Techniques
- Cardiovascular Conditions and Treatments
- Intestinal Malrotation and Obstruction Disorders
- Neonatal Health and Biochemistry
- Cytomegalovirus and herpesvirus research
- Sleep and Wakefulness Research
- Metabolism and Genetic Disorders
- Esophageal and GI Pathology
- Infant Health and Development
- Sleep and related disorders
Vestische Caritas-Kliniken
2012-2024
Witten/Herdecke University
2015-2024
Allen Institute for Immunology
2023
Klinikum Stuttgart
2020
Olgahospital
2020
Klinikum Vest
2007-2018
Boston Children's Hospital
1999-2013
University of Duisburg-Essen
1992-2013
Klinikum Aschaffenburg
2013
Essen University Hospital
1992-2010
Treatment of respiratory distress syndrome in premature infants with continuous positive airway pressure (CPAP) preserves surfactant and keeps the lung open but is insufficient severe deficiency. Traditional administration related to short periods ventilation implies risk injury. CPAP without any may work synergistically. This randomized trial investigated a less invasive application protocol (LISA).To test hypothesis that LISA increases survival bronchopulmonary dysplasia (BPD) at 36 weeks'...
<h3>Importance</h3> Red blood cell transfusions are commonly administered to infants weighing less than 1000 g at birth. Evidence-based transfusion thresholds have not been established. Previous studies suggested higher rates of cognitive impairment with restrictive thresholds. <h3>Objective</h3> To compare the effect liberal vs red strategies on death or disability. <h3>Design, Setting, and Participants</h3> Randomized clinical trial conducted in 36 level III/IV neonatal intensive care...
Near-infrared spectroscopy-derived regional tissue oxygen saturation of haemoglobin (rSt<smlcap>O</smlcap><sub>2</sub>) reflects venous saturation. If cerebral metabolism is stable, rSt<smlcap>O</smlcap><sub>2</sub> can be used as an estimate delivery. The SafeBoosC phase II randomised clinical trial hypothesises that the burden hypo- and hyperoxia reduced by combined use close monitoring a treatment guideline to correct deviations in outside...
Providing less invasive surfactant administration (LISA) to spontaneously breathing preterm infants has been reported reduce mechanical ventilation and bronchopulmonary dysplasia (BPD) in randomised controlled trials. This large cohort study compared these outcome measures between LISA-treated controls.Infants receiving LISA, who were born before 32 gestational weeks enrolled the German Neonatal Network, matched control by age, umbilical cord pH, Apgar-score at 5 min, small for age status,...
<h3>Objective</h3> To evaluate lowest mean arterial blood pressure during the first 24 h of life (minMAP<sup>24</sup>) in very-low-birthweight (VLBW) infants and to identify associations between hypotension short-term outcome. <h3>Design</h3> Retrospective cohort analysis minMAP<sup>24</sup> 4907 VLBW with a gestational age <32 weeks correlation clinical data. Hypotension was defined as being lower than median value all patients same age. <h3>Results</h3> MinMAP<sup>24</sup> values...
<h3>Objective</h3> To describe the presentations, radiologic features, and outcomes of children with autoimmune encephalitis associated myelin oligodendrocyte glycoprotein antibodies (MOG abs). <h3>Methods</h3> Identification fulfilling diagnostic criteria for possible (AE) testing positive serum MOG abs. Chart review comprehensive analysis abs using live cell assays rat brain immunohistochemistry. <h3>Results</h3> Ten (4 girls, 6 boys) AE were identified. The median age at onset was 8.0...
To compare treatment regimens of two widely used natural surfactant preparations Curosurf and Survanta in respiratory distress syndrome (RDS).The effects the on gas exchange, ventilatory requirements, 28 day outcome infants with RDS were compared. Seventy five preterm (birth weight 700-1500 g) requiring artificial ventilation an FIO2 > or = 0.4, randomly selected at 1-24 hours age. One group received initial dose (200 mg/kg); other (100 mg/kg). Patients who remained dependent 0.3 up to...
Background: It was the aim of this study to assess whether very-low-birth-weight (VLBW) infants born small for gestational age (SGA; birth weight less than 10th percentile) are at increased risk late-onset sepsis. Methods: This a prospective, multicenter German Neonatal Network including VLBW from 23 < 32 weeks post menstrual 2009–2011. Outcomes were compared between SGA (birth tenth percentile according and gender) non-SGA infants. The main outcome measure least 1 episode sepsis defined as...
In a large cohort study of the German Neonatal Network (GNN) we aimed to evaluate whether less invasive surfactant administration (LISA) strategy is associated with complications preterm birth. Within observational period n = 7533 very-low-birth-weight infants (VLBWI) gestational age 22 0/7 28 6/7 weeks were enrolled in GNN; 1214 VLBWI never received surfactant, 2624 treated according LISA procedure, 3695 had via endotracheal tube (ETT). was reduced risk for adverse outcome measures...
Importance The inclusion of less invasive surfactant administration (LISA) in the care preterm infants has been found to be beneficial for respiratory outcomes. Recently, OPTIMIST trial higher mortality rates subgroup born at 25 26 weeks’ gestational age (GA) who received treatment while spontaneously breathing. Objective To analyze outcomes among LISA-exposed, highly vulnerable babies than 27 GA within large-scale observational cohort German Neonatal Network. Design, Setting, and...
Since an objective description is essential to determine infant's postnatal condition and efficacy of interventions, two scores were suggested in the past but weren't tested yet: The Specified-Apgar uses 5 items conventional Apgar score; however describes regardless gestational age (GA) or resuscitative interventions. Expanded-Apgar measures interventions needed achieve this condition. We hypothesized that combination both (Combined-Apgar) preterm infants better than either alone. Scores...
Every year in Europe about 25,000 infants are born extremely preterm. These have a 20% mortality rate, and 25% of survivors severe long-term cerebral impairment. Preventative measures key to reduce morbidity an preterm population. The primary objective the SafeBoosC phase II trial is examine if it possible stabilize oxygenation during first 72 hours life through application near-infrared spectroscopy (NIRS) oximetry implementation clinical treatment guideline based on intervention thresholds...
Objective To determine if survival rates of preterm infants receiving active perinatal care improve over time. Design The German Neonatal Network is a cohort study with birth weight <1500 g. All eligible are registered. We analysed data patients discharged between 2011 and 2016. Setting 43 level III neonatal intensive units (NICUs). Patients 8222 gestational age 22/0 28/6 weeks who received care. Interventions Participating NICUs were grouped according to their specific rate from 2013...
Objectives To compare the effect of liberal versus restrictive transfusion strategies on proportion time (%time) spent with intermittent hypoxaemia (IH, ie, arterial haemoglobin oxygen saturation measured by pulse oximetry (SpO 2 ) <80% lasting ≥60 s) in ‘Effects Transfusion Thresholds Neurocognitive Outcome’ (ETTNO) population, and to investigate whether infants above-median exposure IH might benefit more from than those lower exposure. Design, setting, patients Secondary analysis all...
Abstract The German Neonatal Network (GNN) is a prospective cohort study with the focus on long term development of very-low-birth-weight infants. It was aim this to determine detailed information causes mortality in GNN birth 2010. Major contributors hospital were recorded by attending neonatologists for (VLBW) infants born centres data quality approved on-site monitoring. 2 221 VLBW 2010, and death occurred Male carried higher risk than females (58.8% males among non-survivors vs. 51.7%...
Adams–Oliver syndrome (AOS) is a rare developmental disorder, characterized by scalp aplasia cutis congenita (ACC) and transverse terminal limb defects (TTLD). Autosomal dominant forms of AOS are linked to mutations in ARHGAP31, DLL4, NOTCH1 or RBPJ, while DOCK6 EOGT underlie autosomal recessive inheritance. Data on the frequency distribution large cohorts currently limited. The purpose this study was therefore comprehensively examine genetic architecture an extensive cohort. Molecular...
Abstract Aim This revised guideline was coordinated by the German Society for Gynecology and Obstetrics (DGGG), Austrian (OEGGG) Swiss (SGGG). It aims to improve prediction, prevention, management of preterm birth, based on evidence from current literature, experience members guidelines commission, viewpoint self-help organizations. Methods The contributing professional societies organizations developed recommendations statements international literature. were presented adopted using a...
Abstract Aims This is an official guideline of the German Society for Gynecology and Obstetrics (DGGG), Austrian (ÖGGG) Swiss (SGGG). The aim this to improve prediction, prevention management preterm birth based on evidence obtained from recently published scientific literature, experience members commission views self-help groups. Methods participating medical societies organizations developed Recommendations Statements international literature. were adopted following a formal consensus...