A5060641186- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Systemic Lupus Erythematosus Research
- Autoimmune Neurological Disorders and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Parkinson's Disease Mechanisms and Treatments
- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Polyomavirus and related diseases
- Hereditary Neurological Disorders
- Cytokine Signaling Pathways and Interactions
- SARS-CoV-2 and COVID-19 Research
- Autoimmune and Inflammatory Disorders Research
- CNS Lymphoma Diagnosis and Treatment
- Sphingolipid Metabolism and Signaling
- Neurological disorders and treatments
- Immune Response and Inflammation
- Malaria Research and Control
- Rheumatoid Arthritis Research and Therapies
- Long-Term Effects of COVID-19
- Neurological diseases and metabolism
- RNA regulation and disease
Innsbruck Medical University
2016-2025
Universität Innsbruck
2016-2025
Witten/Herdecke University
2015-2023
Vall d'Hebron Hospital Universitari
2020-2023
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2023
Humboldt-Universität zu Berlin
2023
Medical University of Vienna
2004-2022
Klinikum Stuttgart
2020-2022
Olgahospital
2020-2022
Ludwig-Maximilians-Universität München
2022
The ability to mount a prominent inflammatory response bacterial pathogens confers an advantage in innate immune defense but may signal increased risk of atherosclerosis. We determined whether recently discovered genetic variants toll-like receptor 4 (TLR4) that confer differences the elicited by lipopolysaccharide are related development
A subset of patients with neuromyelitis optica spectrum disorders (NMOSD) has been shown to be seropositive for myelin oligodendrocyte glycoprotein antibodies (MOG-IgG). To describe the epidemiological, clinical, radiological, cerebrospinal fluid (CSF), and electrophysiological features a large cohort MOG-IgG-positive optic neuritis (ON) and/or myelitis (n = 50) as well attack long-term treatment outcomes. Retrospective multicenter study. The sex ratio was 1:2.8 (m:f). Median age at onset 31...
Most patients with multiple sclerosis initially present a clinically isolated syndrome. Despite the fact that definite will develop in up to 80 percent of these patients, course disease is unpredictable at its onset and requires long-term observation or repeated magnetic resonance imaging (MRI). We investigated whether presence serum antibodies against myelin oligodendrocyte glycoprotein (MOG) basic protein (MBP) syndrome predicts interval conversion sclerosis.
Abstract Alpha‐synucleinopathies (ASP) are neurodegenerative disorders, characterized by accumulation of misfolded α‐synuclein, selective neuronal loss, and extensive gliosis. It is accepted that microgliosis astrogliosis contribute to the disease progression in ASP. Toll‐like receptors (TLRs) expressed on cells innate immune system, including glia, TLR4 dysregulation may play a role ASP pathogenesis. In this study we aimed define involvement microglial astroglial activation induced...
Abstract Objective Severe inflammation and astrocyte loss with profound demyelination in spinal cord optic nerves are typical pathological features of neuromyelitis optica (NMO). A diagnostic hallmark this disease is the presence serum autoantibodies against water channel aquaporin‐4 (AQP‐4) on astrocytes. Methods We induced acute T‐cell–mediated experimental autoimmune encephalomyelitis Lewis rats confronted animals an additional application immunoglobulins from AQP‐4 antibody–positive...
To report the clinical, radiological, and immunological association of demyelinating disorders with anti–Nmethyl- D-aspartate receptor (NMDAR) encephalitis.Clinical radiological analysis was done a cohort 691 patients anti-NMDAR encephalitis. Determination antibodies to NMDAR, aquaporin-4 (AQP4), myelin oligodendrocyte glycoprotein (MOG) performed using brain immunohistochemistry cell-based assays.Twenty-three encephalitis had prominent magnetic resonance imaging (MRI) and/or clinical...
Neuromyelitis optica (NMO) is a severe inflammatory CNS disorder of putative autoimmune aetiology, which predominantly affects the spinal cord and optic nerves. Recently, highly specific serum reactivity to microvessels, subpia Virchow–Robin spaces was described in patients with NMO [called NMO–IgG (NMO–immunoglobulin G)]. Subsequently, aquaporin-4 (AQP4), most abundant water channel CNS, identified as its target antigen. Strong support for pathogenic role antibody would come from studies...
Abstract Background Serum autoantibodies against the water channel aquaporin-4 (AQP4) are important diagnostic biomarkers and pathogenic factors for neuromyelitis optica (NMO). However, AQP4-IgG absent in 5-40% of all NMO patients target autoimmune response these is unknown. Since recent studies indicate that responses to myelin oligodendrocyte glycoprotein (MOG) can induce an NMO-like disease experimental animal models, we speculate MOG might be autoantigen seronegative NMO. Although...
Antibodies to myelin oligodendrocyte glycoprotein (MOG-IgG) have been suggested play a role in subset of patients with neuromyelitis optica and related disorders.To assess (i) the frequency MOG-IgG large predominantly Caucasian cohort optic neuritis (ON) and/or myelitis; (ii) among AQP4-IgG-positive vice versa; (iii) origin cerebrospinal fluid (CSF); (iv) presence at disease onset; (v) influence activity treatment status on titers.614 serum samples from ON myelitis controls, including 92...
<h3>Objective:</h3> To optimize sensitivity and disease specificity of a myelin oligodendrocyte glycoprotein (MOG) antibody assay. <h3>Methods:</h3> Consecutive sera (n = 1,109) sent for aquaporin-4 (AQP4) testing were screened MOG antibodies (Abs) by cell-based assays using either full-length human (FL-MOG) or the short-length form (SL-MOG). The Abs initially detected Alexa Fluor goat anti-human IgG (H + L) subsequently mouse to IgG1. <h3>Results:</h3> When tested at 1:20 dilution, 40/1,109...
<h3>Objective:</h3> To assess the prognostic value of MOG antibodies (abs) in differential diagnosis acquired demyelinating syndromes (ADS). <h3>Methods:</h3> Clinical course, MRI, MOG-abs, AQP4-abs, and CSF cells oligoclonal bands (OCB) children with ADS 24 months follow-up were reviewed this observational prospective multicenter hospital-based study. <h3>Results:</h3> Two hundred ten included diagnosed acute disseminated encephalomyelitis (ADEM) (n = 60), neuromyelitis optica spectrum...
<h3>Background</h3> Myelin oligodendrocyte glycoprotein (MOG) antibodies have been recently described in children with acute disseminating encephalomyelitis (ADEM), but the clinical and neuroradiological characterisation of this subgroup is lacking. <h3>Objective</h3> To compare features paediatric ADEM without MOG antibodies. <h3>Methods</h3> Clinical course, cerebrospinal fluid (CSF)-, MRI studies, outcome status 33 prospectively studied were reviewed. <h3>Results</h3> (median 1:2560;...
Objective— To determine the association between leukocyte telomere length (TL) and atherosclerosis its clinical sequelae stroke myocardial infarction. Methods Results— Within scope of prospective population-based Bruneck Study, TL was measured by quantitative polymerase chain reaction in 800 women men aged 45 to 84 years (in 1995). The manifestation cardiovascular disease (CVD) (1995–2005) progression (1995–2000) were carefully assessed. shorter than (age-adjusted mean [95% CI], 1.41 [1.33...
Objective: We aimed to report the frequency and implications of antibodies myelin oligodendrocyte glycoprotein (MOG-ab) in adults with demyelinating syndromes suspicious for neuromyelitis optica (NMO). Methods: Samples from 174 patients (48 NMO, 84 longitudinally extensive myelitis (LETM), 39 optic neuritis (ON), three acute disseminated encephalomyelitis (ADEM) who presented initially isolated LETM) were retrospectively examined AQP4-ab MOG-ab using cell-based assays. Results: found 17...
<h3>Objective</h3> Antibodies to cell surface central nervous system proteins help diagnose conditions which often respond immunotherapies. The assessment of antibody assays needs reflect their clinical utility. We report the results a multicentre study aquaporin (AQP) 4 (AQP4-Ab) in neuromyelitis optica spectrum disorders (NMOSD). <h3>Methods</h3> Coded samples from patients with (NMO) or NMOSD (101) and controls (92) were tested at 15 European diagnostic centres using 21 including live...
Myelin oligodendrocyte glycoprotein antibodies (MOG-IgG) are present in a subset of aquaporin-4 (AQP4)-IgG-negative patients with optic neuritis (ON) and/or myelitis. Little is known so far about brainstem involvement MOG-IgG-positive patients. To investigate the frequency, clinical and paraclinical features, course, outcome, prognostic implications ON Retrospective case study. Among 50 myelitis, 15 (30 %) history encephalitis were identified. All negative for AQP4-IgG. Symptoms included...
Antibodies against myelin oligodendrocyte glycoprotein (MOG-IgG) have been reported in patients with aquaporin-4 antibody (AQP4-IgG)-negative neuromyelitis optica spectrum disorders (NMOSD). The objective of this study was to describe optic neuritis (ON)-induced neuro-axonal damage the retina MOG-IgG-positive comparison AQP4-IgG-positive NMOSD patients.Afferent visual system following ON bilaterally assessed 16 a history and compared that patients. In addition, healthy controls matched for...
To compare the reproducibility of 11 antibody assays for immunoglobulin (Ig) G and IgM myelin oligodendrocyte glycoprotein antibodies (MOG-IgG MOG-IgM) from 5 international centers.