A5072843071- Prenatal Screening and Diagnostics
- Assisted Reproductive Technology and Twin Pregnancy
- Pregnancy and preeclampsia studies
- Medical and Health Sciences Research
- Neonatal Respiratory Health Research
- Preterm Birth and Chorioamnionitis
- Maternal and Perinatal Health Interventions
- Pregnancy-related medical research
- Fetal and Pediatric Neurological Disorders
- Health and Medical Studies
- Parvovirus B19 Infection Studies
- Neonatal and fetal brain pathology
- Maternal Mental Health During Pregnancy and Postpartum
- Birth, Development, and Health
- Mesenchymal stem cell research
- Congenital Anomalies and Fetal Surgery
- Uterine Myomas and Treatments
- Congenital Diaphragmatic Hernia Studies
- Child and Adolescent Health
- Cardiovascular Issues in Pregnancy
- Social and Demographic Issues in Germany
- Pregnancy and Medication Impact
- Pelvic floor disorders treatments
- Ectopic Pregnancy Diagnosis and Management
- Infant Development and Preterm Care
University Children's Hospital Tübingen
2016-2025
Universitätsklinikum Tübingen
2015-2025
Institut für Frauengesundheit
2016-2025
University of Tübingen
2015-2024
Universitäts Frauenklinik
2010-2024
Olgahospital
2012-2024
Marienhaus Klinikum Hetzelstift Neustadt
2019
John Wiley & Sons (United Kingdom)
2018
Hudson Institute
2018
Klinikum Mutterhaus der Borromäerinnen
2016
With growing demand for medical information and health applications in pregnancy, the potential of electronic (eHealth) mobile (mHealth) solutions clinical care is increasingly unfolding. However, we still do not know how pregnant women engage with apps, such apps impact routine care, whether benefit expectations are met. Whereas recent research has raised subject user distribution analyzed content pregnancy applications, there a significant knowledge gap regarding what like dislike about...
Abstract Tolerance induction toward the semiallogeneic fetus is crucial to enable a successful pregnancy; its failure associated with abortion or preterm delivery. Skewing T cell differentiation Th2-dominated phenotype seems be pivotal in maternal immune adaption, yet underlying mechanisms are incompletely understood. Myeloid-derived suppressor cells (MDSCs) innate that mediate suppression and increased cord blood of healthy newborns peripheral pregnant women. In this study, we demonstrate...
Mesenchymal stromal cells (MSC) can be isolated from different tissues. They are capable of differentiating in vitro, for example, to osteoblasts, chondrocytes, or adipocytes. In contrast CD34 hematopoietic stem cells, a distinct MSC-defining antibody is not available. Further, lineage-defining antigens such as CD3 CD20 known. contrast, MSC-derived lineage-associated cell surface markers far being established. We therefore investigated expression on human term placenta-derived MSC (pMSC)...
<i>Introduction:</i> The aim of this retrospective clinical study was to compare the accuracy 36 commonly used weight estimation formulae in macrosomic fetuses. <i>Material and Methods:</i> Ultrasound fetal (FW) carried out within 7 days up delivery 350 singleton fetuses with a birth (BW) ≧4,000 g. different for FW compared by, firstly, mean percentage (MPE) absolute error (MAPE), secondly, by frequency distribution differences between estimated BW, thirdly comparing...
Uterus transplantation (UTx) can provide a route to motherhood for women with Mayer-Rokitansky-Küster-Hauser syndrome (MRKHS), congenital disorder characterized by uterovaginal aplasia, but functional ovaries. Based on our four successful living-donor transplantations and two resulting births, this analysis presents parameters relevant standardizing recipient/donor selection, UTx surgery, postoperative treatment, their implementation in routine settings. We descriptively analyzed...
Background: In the case of threatened preterm birth (PTB) before 34th week pregnancy, application antenatal corticosteroids (ACSs) for maturation fetal lung is a standard procedure in perinatal medicine. Common diagnoses ACS use pregnancy are rupture membranes (PPROMs), placental bleeding, premature labor, preeclampsia, oligohydramnios, amniotic infection syndrome (AIS), and cervical insufficiency. The aim this study was to investigate whether current diagnosis, which results ACS, patient’s...
Abstract Purpose This is an official guideline of the German Society for Gynecology and Obstetrics (Deutsche Gesellschaft für Gynäkologie und Geburtshilfe, DGGG), Austrian (Österreichische ÖGGG) Swiss (Schweizerische SGGG). Shoulder dystocia a rare but feared obstetric complication with potentially far-reaching medical consequences mother child. The purpose this to standardize processes which provide individual solutions shoulder in accordance current scientific knowledge clinical practice....
Abstract Purpose This is an official guideline issued by the German Society for Gynecology and Obstetrics (DGGG), Austrian (ÖGGG) Swiss (SGGG). The aims to provide guidance support indication-based decisions in context of vaginal-operative deliveries performance these procedures. intention not rigid standards but show range within which obstetric activities correspond current state scientific knowledge clinical practice. Methods S2k-guideline was developed based on structured consensus...
Background Hematopoietic stem and progenitor cells can interact with their microenvironment via integrins which are adhesion receptors consisting of α β subunits. Current knowledge suggests that the integrin subunits α4 α6 expressed on hematopoietic have distinct roles in retaining bone marrow. The aim our study was to gain insight into expression functions α7-α11 within endosteal cell niche.Design Methods Human osteoblasts isolated from trabecular purified umbilical cord blood or marrow...
To investigate the proportion and type of fetal anomalies that are associated with polyhydramnios to examine whether in cases idiopathic during course pregnancy only diagnosed after birth, antenatal characteristics differ.This was a retrospective study involving all pregnancies defined by deepest pool amniotic fluid ≥8 cm detailed ultrasound examination, 75 g glucose tolerance test TORCH serology.Between 2004 2010, 272 fulfilled inclusion criteria. In 89 (32.7%) 65 (23.9%) cases, there...
To examine the performance of first-trimester ultrasound screening for trisomies 18 and 13, triploidy Turner syndrome based on fetal nuchal translucency thickness (NT), additional markers including anatomy nasal bone (NB), blood flow across tricuspid valve (TV) through ductus venosus (DV) a detailed anomaly scan at 11-13 weeks' gestation.This was retrospective case-matched study involving pregnant women gestation. The population consisted fetuses with trisomy 18, or syndrome. For each fetus...
Fetal behavioral states are defined by fetal movement and heart rate variability (HRV). At 32 weeks of gestational age (GA) the distinction four represented combinations quiet or active sleep awakeness is possible. Prior to weeks, only periods activity quiesence can be distinguished. The increasing synchronization HRV reflects development autonomic nervous system (ANS) control. magnetocardiography (fMCG) detects at high temporal resolution, enabling calculation parameters. This study...
Abstract The number of pregnancies complicated by gestational diabetes (GDM) is increasing worldwide. To identify novel characteristics GDM, we studied miRNA profiles maternal and fetal whole blood cells (WBCs) from GDM normal glucose tolerant (NGT) pregnant women matched for body mass index age. After adjustment weight gain pregnancy week, identified 29 mature micro-RNAs (miRNAs) up-regulated in one which, i.e., miRNA-340, was validated qPCR. mRNA protein expression PAIP1, a miRNA-340...
To assess the risk of complications in women undergoing termination pregnancy (TOP) for fetal defects and to examine impact gestational age on complication rate.
Prevalence rates of peripartum depression and anxiety are high correlate with adverse maternal neonatal outcomes. Mindfulness-based interventions (MBI) have been shown to reduce mental distress during pregnancy. A multicenter, randomized controlled study was conducted after screening for depressive symptoms. The intervention group (IG) given access an 8-week supervised eMBI between weeks 29 36 pregnancy followed up 5 months postpartum. Psychometric data were collected using the Edinburgh...
In animal models, cell therapies for different diseases or injuries have been very successful. Preclinical studies with cells aiming at a stroke, heart attack, and other emergency situations were promising but sometimes failed translation in clinical situations. We, therefore, investigated if human placenta-derived mesenchymal stromal can be injected pigs without provoking rejection to serve as xenogenic transplantation model bridge preclinical more future studies. Male isolated, expanded,...
Mesenchymal stromal cells (MSCs) are multipotent that can be differentiated in vitro into a variety of cell types, including adipocytes or osteoblasts. Our recent studies indicated high expression CD146 on MSCs from bone marrow correlates with their robust osteogenic differentiation potential. We therefore investigated if the placenta similar The were isolated specifically endometrial and fetal parts human term expanded separate cultures compared as controls. surface antigens was by flow...