Sara Y. Brucker
A5049945196- Breast Cancer Treatment Studies
- Endometrial and Cervical Cancer Treatments
- Advanced Breast Cancer Therapies
- Ovarian cancer diagnosis and treatment
- Cancer Cells and Metastasis
- Gynecological conditions and treatments
- Cancer Genomics and Diagnostics
- Cancer survivorship and care
- HER2/EGFR in Cancer Research
- Uterine Myomas and Treatments
- Medical and Health Sciences Research
- Economic and Financial Impacts of Cancer
- Genetic factors in colorectal cancer
- Breast Lesions and Carcinomas
- Endometriosis Research and Treatment
- Estrogen and related hormone effects
- Cervical Cancer and HPV Research
- Cancer Treatment and Pharmacology
- Clinical practice guidelines implementation
- Cancer Risks and Factors
- Maternal Mental Health During Pregnancy and Postpartum
- Health and Medical Studies
- Intestinal and Peritoneal Adhesions
- Female Genital Mutilation/Cutting Issues
- Urological Disorders and Treatments
University Children's Hospital Tübingen
2016-2025
University of Tübingen
2015-2024
Universitätsklinikum Tübingen
2016-2024
Universitäts Frauenklinik
2012-2024
Institut für Frauengesundheit
2013-2024
Bernstein Center for Computational Neuroscience Tübingen
2020
Olgahospital
2008-2020
University of British Columbia
2015
BC Cancer Agency
2015
Synlab (Germany)
2015
Endometrial carcinoma (EC) molecular classification based on four subclasses identified in The Cancer Genome Atlas (TCGA) has gained relevance recent years due to its prognostic utility and potential predict benefit from adjuvant treatment. While most ECs can be classified a single classifier (POLE exonuclease domain mutations - POLEmut, MMR deficiency MMRd, p53 abnormal p53abn), small but clinically relevant group of tumours harbour more than one classifying feature are referred as...
Abstract Pathogenic somatic missense mutations within the DNA polymerase epsilon ( POLE ) exonuclease domain define important subtype of ultramutated tumours (‘ ‐ultramutated’) novel molecular classification endometrial carcinoma (EC). However, clinical implementation this classifier requires systematic evaluation pathogenicity mutations. To address this, we examined base changes, tumour mutational burden (TMB), microsatellite instability (MSI) status, variant frequency, and results from six...
Many women with ovarian endometrioid carcinoma present concurrent endometrial carcinoma. Organ-confined and low-grade synchronous tumors (SEOs) clinically behave as independent primary rather than a single advanced-stage We used 18 SEOs to investigate the ancestral relationship between components. Based on both targeted exome sequencing, 17 of patient cases simultaneous cancer endometrium ovary from our series showed evidence clonal relationship, ie, tumor metastasis. Eleven fulfilled...
Significance Despite the revolution in cancer therapy initiated by checkpoint inhibitors, durable clinical responses remain sporadic many types of cancer, including ovarian cancer. Understanding which antigens are essentially presented tumor cells and further able to be recognized T provides a major step toward novel effective targeted immunotherapies. In this study, we comprehensively analyzed immunopeptidomic landscape carcinoma compared it variety benign sources identify exclusively on...
Abstract Background The aim of this retrospective study was to describe the spectrum genital and associated malformations in women with Mayer-Rokitansky-Küster-Hauser syndrome using evaluated diagnostic procedures Vagina Cervix Uterus Adnex – Malformation classification system (VCUAM). Methods 290 MRKH were clinically clinical examinations, abdominal perineal/rectal ultrasound, MRI, laparoscopy. Results Classification female malformation according possible 284 (97.9%). Complete atresia (V5b)...
Identification of families at risk for ovarian cancer offers the opportunity to consider prophylactic surgery thus reducing mortality. So far, identification potentially affected in Germany was solely performed via family history and numbers members with breast or cancer. However, neither prevalence deleterious variants BRCA1/2 nor reliability as trigger genetic counselling has ever been evaluated.
The newly developed Proactive Molecular Risk Classifier for Endometrial Cancer (ProMisE) has consistently been shown to be prognostically significant in endometrial carcinomas (EC). Recently, we and others have demonstrated L1 cell-adhesion molecule (L1CAM) a indicator of high-risk disease EC. In the current study, it was our aim determine prognostic significance aberrant L1CAM expression ProMisE subgroups large, single centre, population-based EC cohort.ProMisE (POLE; MMR-D; p53 wt/NSMP;...
Abstract Background In addition to the established association between general obesity and breast cancer risk, central circulating fasting insulin glucose have been linked development of this common malignancy. Findings from previous studies, however, inconsistent, nature associations is unclear. Methods We conducted Mendelian randomization analyses evaluate using genetic instruments, with insulin, glucose, 2-h body mass index (BMI) BMI-adjusted waist-hip-ratio (WHRadj BMI). first confirmed...
ObjectiveTo improve the laparoscopic Vecchietti procedure and optimize instrumentation for treatment of congenital vaginal agenesis with a minimum complications optimal functional outcome, in comparison conventional procedure.DesignProspective comparative interventional study.SettingUniversity hospital.Patient(s)One hundred one patients agenesis.Intervention(s)The interventions compared were [1] new laparoscopic, Vecchietti-based method using vaginoabdominal blunt perforation without...
The Mayer–Rokitansky–Küster–Hauser (MRKH) syndrome is characterized by congenital aplasia of the uterus and upper part vagina in women who usually have normal ovaries a 46, XX karyotype. MRKH can occur as an isolated form (type I) or combination with various malformations syndromic type II MRKH. To date, most cases underlying etiology remains unclear. Recently, approximately 6% patients, deletions chromosomal region 17q12 been identified. LHX1 gene, which located deletion interval, has...
Abstract We aimed to validate the prognostic association of p16 expression in ovarian high‐grade serous carcinomas (HGSC) and explore it other carcinoma histotypes. protein was assessed by clinical‐grade immunohistochemistry 6525 including 4334 HGSC using tissue microarrays from 24 studies participating Ovarian Tumor Tissue Analysis consortium. patterns were interpreted as abnormal (either overexpression referred block or absence) normal (heterogeneous). CDKN2A (which encodes p16) mRNA also...
The telomerase reverse transcriptase (TERT) gene is highly expressed in stem cells and silenced upon differentiation. Cancer can attain immortality by activating TERT to maintain telomere length activity, which a crucial step of tumorigenesis. Two somatic mutations the promoter (C228T; C250T) have been identified as gain-of-function that promote transcriptional activation multiple cancers, such melanoma glioblastoma. A recent study investigating ovarian carcinomas found C228T C250T 15.9%...
Abstract Purpose: Endometrioid ovarian carcinoma (ENOC) is generally associated with a more favorable prognosis compared other carcinomas. Nonetheless, current patient treatment continues to follow “one-size-fits-all” approach. Even though tumor staging offers stratification, personalized treatments remain elusive. As ENOC shares many clinical and molecular features its endometrial counterpart, we sought investigate The Cancer Genome Atlas–inspired (EC) subtyping in cohort of ENOC....
Background Peripartum depression and anxiety disorders are highly prevalent correlated with adverse maternal neonatal outcomes. Antenatal care in Germany does not yet include structured screening effective low-threshold treatment options for women facing peripartum disorders. Mindfulness-based interventions (MBIs) increasingly becoming a focus of interest the management such patients. Studies have shown decrease pregnancy-related stress expectant mothers following mindfulness programs....
PURPOSE A polygenic risk score (PRS) consisting of 313 common genetic variants (PRS ) is associated with breast cancer and contralateral cancer. This study aimed to evaluate the association PRS clinicopathologic characteristics of, survival following, METHODS Women invasive were included, 98,397 European ancestry 12,920 Asian ancestry, from Breast Cancer Association Consortium (BCAC), 683 women MINDACT trial. Associations between characteristics, including 70-gene signature for MINDACT,...