A5014642548- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Breast Cancer Treatment Studies
- Cancer Cells and Metastasis
- Endometriosis Research and Treatment
- Breast Lesions and Carcinomas
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- Sphingolipid Metabolism and Signaling
- Reproductive System and Pregnancy
- Cervical Cancer and HPV Research
- MRI in cancer diagnosis
- RNA Research and Splicing
- Medical Imaging Techniques and Applications
- Uterine Myomas and Treatments
- HER2/EGFR in Cancer Research
- Cancer Treatment and Pharmacology
- Estrogen and related hormone effects
- Epigenetics and DNA Methylation
- Cancer Diagnosis and Treatment
- BRCA gene mutations in cancer
- Immune Cell Function and Interaction
- Gynecological conditions and treatments
- Kruppel-like factors research
- Circular RNAs in diseases
University Children's Hospital Tübingen
2015-2025
Universitätsklinikum Tübingen
2013-2024
University of Tübingen
2015-2024
Universitäts Frauenklinik
2024
Taipei Institute of Pathology
2013-2023
UNSW Sydney
2023
The University of Melbourne
2023
Kumamoto University Hospital
2018
Barts Health NHS Trust
2018
Belfast Health and Social Care Trust
2018
Cytotoxic CD8+ tumor-infiltrating lymphocytes (TILs) participate in immune control of epithelial ovarian cancer; however, little is known about prognostic patterns TILs by histotype and relation to other clinical factors.
Many women with ovarian endometrioid carcinoma present concurrent endometrial carcinoma. Organ-confined and low-grade synchronous tumors (SEOs) clinically behave as independent primary rather than a single advanced-stage We used 18 SEOs to investigate the ancestral relationship between components. Based on both targeted exome sequencing, 17 of patient cases simultaneous cancer endometrium ovary from our series showed evidence clonal relationship, ie, tumor metastasis. Eleven fulfilled...
Pseudomyxoma peritonei (PMP) is a poorly understood condition characterized by mucinous ascites and multifocal peritoneal tumors. Women with PMP often have tumors involving both the appendix ovaries. Several previous histopathological immunohistochemical studies of suggested that most, if not all, cases in women are derived from adenomas rather than primary ovarian A few molecular genetics been recently reported. However, these analyzed only small number some included heterogeneous group...
Adult stem cells are thought to be responsible for the high regenerative capacity of human endometrium, and have been implicated in pathology endometriosis endometrial carcinoma. The RNA-binding protein Musashi-1 is associated with maintenance asymmetric cell division neural epithelial progenitor cells. We investigated expression localization endometrial, endometriotic carcinoma tissue specimens 46 patients. qPCR revealed significantly increased mRNA endometrium compared myometrium....
The SRY-related HMG-box family of transcription factors member SOX2 has been mainly studied in embryonic stem cells as well early foregut and neural development. More recently, was shown to participate reprogramming adult somatic a pluripotent cell state implicated tumorigenesis various organs. In breast cancer, expression reported feature basal-like tumors. this study, we assessed 95 primary tumors postmenopausal cancer patients. Samples from patients diagnosed treated at the University...
Abstract Background Tumour size in breast cancer influences therapeutic decisions. The purpose of this study was to evaluate sizing primary using mammography, sonography and magnetic resonance imaging (MRI) thereby establish which method most accurately corresponds with the histological result. Methods Data from 121 patients were analysed a retrospective study. results divided into groups “ductal carcinoma situ (DCIS)”, invasive ductal (IDC) + “invasive (IDC)”, lobular (ILC)” “other tumours”...
Significance Despite the revolution in cancer therapy initiated by checkpoint inhibitors, durable clinical responses remain sporadic many types of cancer, including ovarian cancer. Understanding which antigens are essentially presented tumor cells and further able to be recognized T provides a major step toward novel effective targeted immunotherapies. In this study, we comprehensively analyzed immunopeptidomic landscape carcinoma compared it variety benign sources identify exclusively on...
Although endometrial carcinoma (EC) is generally considered to have a good prognosis, over 20% of women with EC die their disease, projected increase in both incidence and mortality the next few decades. The aim accurate prognostication ensure that patients receive optimal treatment are neither overtreated nor undertreated, thereby improving patient outcomes overall. Patients can be categorized into prognostic risk groups based on clinicopathologic findings. Other than tumor type grade,...
The SRY-related HMG-box family of transcription factors member SOX2 regulates stemness and pluripotency in embryonic stem cells plays important roles during early embryogenesis. More recently, expression was documented several tumor types including ovarian carcinoma, suggesting an involvement regulation cancer (CSC). Intriguingly, however, studies exploring the predictive value protein with respect to histopathologic clinical parameters report contradictory results individual tumors,...
The newly developed Proactive Molecular Risk Classifier for Endometrial Cancer (ProMisE) has consistently been shown to be prognostically significant in endometrial carcinomas (EC). Recently, we and others have demonstrated L1 cell-adhesion molecule (L1CAM) a indicator of high-risk disease EC. In the current study, it was our aim determine prognostic significance aberrant L1CAM expression ProMisE subgroups large, single centre, population-based EC cohort.ProMisE (POLE; MMR-D; p53 wt/NSMP;...
Pharmacological activation of cannabinoid receptors elicits antitumoral responses in different cancer models. However, the biological role these tumor physio-pathology is still unknown. We analyzed CB2 receptor protein expression two series 166 and 483 breast samples operated University Hospitals Kiel, Tübingen, Freiburg between 1997 2010 mRNA previously published DNA microarray datasets. The oncogenesis was studied by generating a mouse line that expresses human V-Erb-B2 Avian...
Dissecting cellular signalling requires the analysis of large number proteins. The DigiWest approach we describe here transfers western blot to a bead-based microarray platform. By combining gel-based protein separation with immobilization on microspheres, hundreds replicas initial are created, thus enabling comprehensive limited material, such as cells collected by laser capture microdissection, and extending traditional blotting reach proteomic scales. combination molecular weight...
Determining the origin of uterine adenocarcinomas can be difficult in biopsy and curettage specimens because morphologic spectrum endocervical endometrial overlaps. In hysterectomy specimens, primary site is often equivocal for tumors that involve lower segment endocervix lack identifiable precursor lesions. Most (ECAs) contain high-risk human papillomavirus (HPV) DNA, whereas (EMAs) rarely do. p16 an inhibitor ofcyclin-dependent kinases, overexpression has been observed cervical...
Testing for E6/E7 mRNA in cells infected with high-risk (HR) human papillomavirus (HPV) might improve the specificity of HPV testing identification cervical precancerous lesions. Here we compared RNA-based Aptima (AHPV) assay (Hologic) and DNA-based Hybrid Capture 2 (HC2) test (Qiagen) to liquid-based cytology (LBC) women undergoing routine screening. A total 10,040 women, 30 60 years age, were invited participate study, 9,451 whom included analysis. Specimens tested centrally by LBC, AHPV...
Abstract We aimed to validate the prognostic association of p16 expression in ovarian high‐grade serous carcinomas (HGSC) and explore it other carcinoma histotypes. protein was assessed by clinical‐grade immunohistochemistry 6525 including 4334 HGSC using tissue microarrays from 24 studies participating Ovarian Tumor Tissue Analysis consortium. patterns were interpreted as abnormal (either overexpression referred block or absence) normal (heterogeneous). CDKN2A (which encodes p16) mRNA also...
Objective Increased numbers of tumor-infiltrating lymphocytes (TILs) in high-grade serous ovarian cancer (HGSC) are associated with improved clinical outcome. Intraepithelial localization TILs might be regulated by specific homing receptors, such as CD103, which is widely expressed intraepithelial lymphocytes. Given the emerging role CD103 + TILs, we aimed to assess their contribution prognostic value immunoscoring HGSC. Methods The density intratumoral CD3 and was examined...
Endometrial cancer is the most common gynecologic neoplasm in developed countries; however, updated universal guidelines are currently not available to handle specimens obtained during surgical treatment of patients affected by this disease. This article presents recommendations on how gross and submit sections for microscopic examination hysterectomy other tissues removed management endometrial such as salpingo-oophorectomy, omentectomy, lymph node dissection—including sentinel nodes. In...
The histopathologic features of adult granulosa cell tumors (AGCTs) are relatively nonspecific, resulting in misdiagnosis other cancers as AGCT, a problem that has not been well characterized. FOXL2 mutation testing was used to stratify 336 AGCTs from three European centers into categories: 1) mutant molecularly defined AGCT (MD-AGCT) (n = 256 336), 2) wild-type 17 3) misdiagnosed tumor types 63 336). All statistical tests were two-sided. overall and disease-specific survival the cases lower...
The telomerase reverse transcriptase (TERT) gene is highly expressed in stem cells and silenced upon differentiation. Cancer can attain immortality by activating TERT to maintain telomere length activity, which a crucial step of tumorigenesis. Two somatic mutations the promoter (C228T; C250T) have been identified as gain-of-function that promote transcriptional activation multiple cancers, such melanoma glioblastoma. A recent study investigating ovarian carcinomas found C228T C250T 15.9%...