A5016818187- Cervical Cancer and HPV Research
- Global Cancer Incidence and Screening
- Endometrial and Cervical Cancer Treatments
- COVID-19 and healthcare impacts
- Genital Health and Disease
- Preterm Birth and Chorioamnionitis
- Urological Disorders and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Hepatitis B Virus Studies
- Ovarian cancer diagnosis and treatment
- Reproductive tract infections research
- Endometriosis Research and Treatment
- Pregnancy-related medical research
- Ectopic Pregnancy Diagnosis and Management
- Statistical Methods in Clinical Trials
- Colorectal Cancer Screening and Detection
- Employment and Welfare Studies
- Climate Change and Health Impacts
- Cancer Risks and Factors
- Clinical practice guidelines implementation
- Economic and Financial Impacts of Cancer
- Colorectal and Anal Carcinomas
- Artificial Intelligence in Healthcare and Education
- Hemostasis and retained surgical items
- Parasitic infections in humans and animals
Peacocks Medical Group (United Kingdom)
2024
London Cancer
2009-2023
King's College London
2018-2023
UK Health Security Agency
2022
Guy's Hospital
2018-2021
U-M Rogel Cancer Center
2021
Queen Mary University of London
2009-2018
Chinese Academy of Medical Sciences & Peking Union Medical College
2017
Instituto de Química y Fisicoquímica Biológicas
2016
University of Buenos Aires
2016
<b>Objective</b> To study the effect of cervical screening on incidence cancer as a function age with particular focus women screened under 25. <b>Design</b> Population based case-control prospectively recorded data screening. <b>Setting</b> Selected centres in United Kingdom. <b>Participants</b> 4012 aged 20-69 invasive diagnosed participating and two controls per case individually matched area residence. <b>Main outcome measures</b> Odds ratios for strength association between at ages....
It is well established that screening can prevent cervical cancer, but the magnitude of impact regular on cancer mortality unknown. Population-based case–control study using prospectively recorded data, England 1988–2013. Case women had diagnosed during April 2007–March 2013 aged 25–79 years (N=11 619). Two cancer-free controls were individually age matched to each case. We used conditional logistic regression estimate odds ratio (OR) developing stage-specific for regularly screened or...
Screening has had a major impact on cervical cancer in many countries. Although there can be no doubt about its effectiveness preventing squamous-cell carcinoma, is little evidence of any benefit adenocarcinoma and adenosquamous carcinoma the cervix, authors have concluded that it ineffective. A population-based case-control design was used women aged 20-69 United Kingdom, with information screening obtained from routine databases. Among 3,305 cases known histology, 641 133 carcinoma. The...
Background There is little consensus, and minimal evidence, regarding the age at which to stop cervical screening. We studied association between screening 50–64 y cancer 65–83 y. Methods Findings Cases were women (n = 1,341) diagnosed with 1 April 2007 31 March 2012 in England Wales; age-matched controls 2,646) randomly selected from population registers. Screening details 1988 onwards extracted national databases. calculated odds ratios (OR) for different histories subsequent cancer. Women...
Receptor activity-modifying proteins (RAMPs) are single-transmembrane that transport the calcitonin receptor-like receptor (CRLR) to cell surface. RAMP 1-transported CRLR is a gene-related peptide (CGRP) receptor. 2- or 3-transported an adrenomedullin The role of RAMPs beyond their interaction with CRLR, class II G protein-coupled receptor, unclear. In this study, we have examined in generating amylin phenotypes from (CT) gene product. Cotransfection 1 3 human CT lacking 16-amino acid insert...
<b>Objective</b> To determine the association between depth of excision cervical intraepithelial neoplasia and risk preterm birth. <b>Design</b> Case-control study nested in record linkage cohort study. <b>Setting</b> 12 hospitals England. <b>Participants</b> From a 11 471 women with at least one histological sample taken colposcopy live singleton birth (before or after colposcopy), 1313 (20-36 weeks) were identified frequency matched on maternal age delivery, parity, site to term births...
While the incidence of squamous carcinoma cervix has declined in countries with organised screening, adenocarcinoma become more common. Cervical screening by cytology often fails to prevent adenocarcinoma. Using prospectively recorded cervical data England and Wales, we conducted a population‐based case–control study examine whether leads early diagnosis down‐staging Conditional logistic regression modelling was carried out provide odds ratios (ORs) 95% confidence intervals (CIs) on 12,418...
Abstract Background The COVID-19 pandemic has disrupted cervical cancer screening services. Assuming increases to capacity are unrealistic, we propose two recovery strategies: one extends the interval by 6 months for all and other 36/60 months, but only women who have already missed being screened. Methods Using routine statistics from England estimate number of affected delays screening. We used published research proportion age with high-grade intraepithelial neoplasia progression rates...
Testing for E6/E7 mRNA in cells infected with high-risk (HR) human papillomavirus (HPV) might improve the specificity of HPV testing identification cervical precancerous lesions. Here we compared RNA-based Aptima (AHPV) assay (Hologic) and DNA-based Hybrid Capture 2 (HC2) test (Qiagen) to liquid-based cytology (LBC) women undergoing routine screening. A total 10,040 women, 30 60 years age, were invited participate study, 9,451 whom included analysis. Specimens tested centrally by LBC, AHPV...
In England, routine invitations for cervical screening were reduced between April 2020 and June due to the COVID-19 pandemic. We quantify impact of disruptions on attendance excess diagnoses cancer (CC).
Human papillomavirus (HPV) vaccination has been approved in more than 90 countries and is being implemented many of these. In the UK, for girls aged 12–13 with catch-up up to age 18 was introduced 2008, using bivalent GSK vaccine (Cervarix). We modelled proportion abnormal smears, cervical intraepithelial neoplasia grade 3 (CIN3) invasive cancer, which will be prevented women 20–29 UK as a result HPV vaccination. It take years full benefit achieved. The earliest effects seen 20–29. With 80%...
DNA methylation changes in human papillomavirus type 16 (HPV16) are common and might be important for identifying women at increased risk of cervical cancer. Using recently published data from Costa Rica we developed a classification score to differentiate with intraepithelial neoplasia grade 2 or 3 (CIN2/3) those no evident high‐grade lesions. Here, aim investigate the performance using UK. Exfoliated cells baseline 6‐months follow‐up were analyzed 84 selected randomized clinical trial...
<h2>Summary</h2><h3>Background</h3> In the next 25 years, epidemiology of cervical cancer in England, UK, will change: human papillomavirus (HPV) screening be primary test for cancer. Additionally, proportion women screened regularly is decreasing and who received HPV vaccine are due to attend first time. Therefore, we aimed estimate how vaccination against HPV, changes test, falling coverage affect incidence England up 2040. <h3>Methods</h3> We did a data modelling study that combined...
There was concern that failure to screen women aged 20–24 years would increase the number of cancers or advanced in 20–29 years. We describe characteristics diagnosed with cervical cancer England and examine association between period diagnosis, screening history FIGO stage. used data on 1800 April 2007 March 2012 at age from National Audit Invasive Cervical Cancers. The majority (995, 62% those known stage) were stage 1A. Cancer rare (12% years), when compared 25 (24%) 26–29 (63%); however,...
Objectives To estimate the impact of COVID-19 infection on requirement for social care services among adults aged >=50 years in North-West London. Design Population based matched cohort study using linked routinely collected electronic care, primary and hospital records (the Discover dataset). Setting Approximately 4.7 million people with a general practitioner record Participants 150,654 first diagnosis between January 2020 February 2023 547,704 propensity score comparators without...
We report on a symposium held in London, UK, 16 February 2015 to discuss the association between surgical treatment of cervical intraepithelial neoplasia (CIN) and subsequent preterm birth, consider appropriate recommendations for CIN management treated women during pregnancy. The meeting focused grades 2 3 that have been managed surgically. Clinical practice varies internationally: some countries knife excision is common; others, laser ablation choice; predominantly involves outpatient...
Longitudinal data on the E6/E7 mRNA-based Aptima human papillomavirus (AHPV) assay exceeding three years in comparison to gold standard Digene Hybrid Capture 2 (HC2) test are not available. We previously reported cross-sectional of German AHPV Screening Trial (GAST) which 10,040 women were recruited and tested by liquid-based cytology, HC2 assay, assay.
To quantify the benefits (cancer prevention and down-staging) harms (recall excess treatment) of cervical screening starting from age 20 years rather than 25 years. We use routine cancer incidence statistics Wales (for years) England (screening years), unpublished data National Audit Invasive Cervical Cancer to estimate number of: tests, women with abnormal results, referrals colposcopy, treated, diagnoses micro-invasive (stage 1A) frank-invasive IB+) cancers (under three different...
The rates of cervical cancer (CxCa) in England among women aged 20-24yrs increased from 2.7 2012 to 4.6 per 100,000 2014 (p=0.0006). There was concern that the sudden increase linked withdrawal screening 20-24 (a policy affected born since 1984). We analyse granular data on age and FIGO stage at diagnosis using a generalised linear model see whether unprecedented CxCa young change which first invitation sent (from 25.0 24.5). Annual 20.0-24.5yrs decreased gradually over time, whereas...
Abstract Others have argued that as many a third of women treated for high‐grade cervical intraepithelial neoplasia (CIN) would developed cancer in the absence screening and treatment. Under various assumptions using past data on CIN grade 3 (CIN3) registrations England Scotland, we estimate what rates been screening. Data carcinoma situ Scotland were used to project additional numbers invasive cancers resulted had not treated. We compare resulting (under different models) with recorded...