A5071419458- Global Cancer Incidence and Screening
- Cervical Cancer and HPV Research
- Colorectal Cancer Screening and Detection
- Endometrial and Cervical Cancer Treatments
- COVID-19 and healthcare impacts
- Obesity, Physical Activity, Diet
- Eating Disorders and Behaviors
- Gastric Cancer Management and Outcomes
- Child Nutrition and Feeding Issues
- Genital Health and Disease
- Hepatitis B Virus Studies
- Diverticular Disease and Complications
- Reproductive tract infections research
- Mental Health Research Topics
- Cancer Risks and Factors
- Economic and Financial Impacts of Cancer
- Ethics in Clinical Research
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Ovarian cancer diagnosis and treatment
- Mindfulness and Compassion Interventions
- Child and Adolescent Health
- Microscopic Colitis
- Early Childhood Education and Development
- Behavioral Health and Interventions
- Mental Health Treatment and Access
Erasmus MC
2019-2025
Wageningen University & Research
2024
Erasmus University Rotterdam
2020
Maastricht University
2008-2011
Many breast, cervical, and colorectal cancer screening programmes were disrupted due to the COVID-19 pandemic. This study aimed estimate effects of five restart strategies after disruption on required capacity burden.Microsimulation models simulated for screening. The estimated capacity, incidence, cancer-specific mortality a 6 months. varied in whether screens caught up or not and, if so, immediately delayed, upper age limit was increased.The without catch-up missed led an increase 2.0,...
Importance Cervical screening guidelines in the US recommend that most females can exit routine at age 65 years following 2 recent consecutive negative cotest results (concurrent human papillomavirus and cytology tests). However, empirical data on subsequent risks of cancer death this subgroup are limited. Objective To estimate cervical among who meet cotesting criteria to screening. Design, Setting, Participants In decision analytical comparative modeling study, 4 models from Cancer...
Objective We aim to compare the cost‐effectiveness of old cytology programme with new high‐risk human papillomavirus (hrHPV) screening programme, using performance indicators from Dutch hrHPV programme. Design Model‐based analysis. Setting The Netherlands. Population 30‐year‐old unvaccinated females followed up lifelong. Methods updated microsimulation analysis (MISCAN) model most recent epidemiological and data simulated both programmes, behaviour costs observed in each Sensitivity analyses...
Population-level estimates in timeframes for reaching cervical cancer (CC) elimination (ie, <4 cases per 100,000 women) the United States may mask potential disparities achieving among sub-populations. We used three independent Cancer Intervention and Surveillance Modeling Network (CISNET) models to estimate differences time CC across seven strata of correlated screening human papillomavirus vaccination uptake, based on national survey data. Compared average population, was achieved ≥22...
With the implementation of primary high-risk human papillomavirus (hrHPV) screening in Netherlands, an increase was observed number unnecessary referrals (≤Cervical Intraepithelial Neoplasia (CIN) 1) to colposcopy. We aimed investigate which alternative triage strategies safely reduce HPV-based cervical cancer programmes.Microsimulation model MISCAN used simulate unvaccinated cohort ten million 30-year old Dutch women. calculated referrals, incidence, mortality, costs and QALYs for 24...
Aiming to support European countries in improving their breast, cervical, and colorectal cancer (CRC) screening programmes, the EU-TOPIA consortium has developed an online user-friendly tool (the evaluation tool; https://miscan.eu-topia.org) based on Microsimulation Screening Analysis (MISCAN) model. We designed platform that allows stakeholders use country-specific data (demographic, epidemiological, information) quantify future harms benefits of different scenarios country. Current...
The aim of this study was to describe trends in the diagnosis and treatment women referred from national screening program with cervical intraepithelial neoplasia (CIN) Netherlands, compare these guidelines identify potential areas for improvement new primary high-risk HPV program.We conducted a population-based cohort using data Dutch pathology archive. Women aged 29-63 years who took part between 1 January 2005 31 December 2014 were selected. Three referral groups identified: direct...
Background. Validated microsimulation models have been shown to be useful tools in providing support for colorectal cancer (CRC) screening decisions. Aiming assist European countries reducing CRC mortality, we developed and validated three regional evaluating Europe. Methods. Microsimulation Screening Analysis–Colon (MISCAN-Colon) model versions Italy, Slovenia, Finland were quantified using data from different national institutions. These against the best available evidence effectiveness of...
In 2018, only half of US women obtained all evidence-based cancer screenings. This proportion may have declined during the COVID-19 pandemic because social distancing, high-risk factors, and fear.
Abstract Background Human papillomavirus (HPV) vaccination and intensifying screening expedite cervical cancer (CC) elimination, yet also deteriorate the balance between harms benefits of screening. We aimed to find strategies that eliminate CC rapidly but maintain an acceptable harms-benefits ratio Methods Two microsimulation models (STDSIM MISCAN) were applied simulate HPV transmission for Dutch female population 2022 2100. estimated elimination year ratios 228 unique scenarios varying in...
Eastern European countries are contemplating to introduce the high-risk Human Papillomavirus (HPV)-test as primary screening test for their cervical cancer programme, but its optimal protocol is yet unknown. The aim of this study was compare costs, effects and cost-effectiveness different HPV-screening protocols in Europe, using Slovenia an example with respect local preferences screening.We evaluated 968 protocols, which varied by ages, triage tests (i.e. cytology, repeat HPV and/or...
We evaluated how temporary disruptions to primary cervical cancer (CC) screening services may differentially impact women due heterogeneity in their history and test modality. used three CC models project the short- long-term health impacts assuming an underlying frequency (i.e., 1, 3, 5, or 10 yearly) under alternative COVID-19-related disruption scenarios 1-, 2-, 5-year delay) versus no delay context of both cytology-based human papillomavirus (HPV)-based screening. Models projected a...