A5010339528- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Global Cancer Incidence and Screening
- Radiomics and Machine Learning in Medical Imaging
- Colorectal Cancer Screening and Detection
- Esophageal Cancer Research and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Economic and Financial Impacts of Cancer
- Head and Neck Cancer Studies
- Health Systems, Economic Evaluations, Quality of Life
- Delphi Technique in Research
- Cervical Cancer and HPV Research
- Multiple and Secondary Primary Cancers
- Advanced Radiotherapy Techniques
- Social and Behavioral Studies
- Health Policy Implementation Science
- Gastric Cancer Management and Outcomes
- Lung Cancer Research Studies
- Genetic factors in colorectal cancer
- Cancer Risks and Factors
- Meta-analysis and systematic reviews
Erasmus MC
2016-2025
Erasmus University Rotterdam
2014-2021
Faculty of Public Health
2021
John Wiley & Sons (United States)
2021
Dartmouth–Hitchcock Medical Center
2013
Fred Hutch Cancer Center
2013
National Cancer Institute
2013
Brock University
2013
Stanford University
2013
University of Michigan
2013
There are limited data from randomized trials regarding whether volume-based, low-dose computed tomographic (CT) screening can reduce lung-cancer mortality among male former and current smokers.
The optimum screening policy for lung cancer is unknown.
<h3>Background</h3> In the USA annual lung cancer screening is recommended. However, optimal strategy (eg, interval, rounds) unknown. This study provides results of fourth round after a 2.5-year interval in Dutch-Belgian Lung Cancer Screening trial (NELSON). <h3>Methods</h3> Europe9s largest, sufficiently powered randomised was designed to determine whether low-dose CT reduces mortality by ≥25% compared with no 10 years follow-up. The arm (n=7915) received at baseline, 1 year, 2 and 2.5...
Background Selection of candidates for lung cancer screening based on individual risk has been proposed as an alternative to criteria age and cumulative smoking exposure (pack-years). Nine previously established models were assessed their ability identify those most likely develop or die from cancer. All considered various aspects (smoking status, duration, cigarettes per day, pack-years smoked, time since cessation) predictors. In addition, some factors such gender, race, ethnicity,...
<h3>Importance</h3> The US Preventive Services Task Force (USPSTF) is updating its 2013 lung cancer screening guidelines, which recommend annual for adults aged 55 through 80 years who have a smoking history of at least 30 pack-years and currently smoke or quit within the past 15 years. <h3>Objective</h3> To inform USPSTF guidelines by estimating benefits harms associated with various low-dose computed tomography (LDCT) strategies. <h3>Design, Setting, Participants</h3> Comparative...
Background The National Lung Screening Trial (NLST) results indicate that computed tomography (CT) lung cancer screening for current and former smokers with three annual screens can be cost-effective in a trial setting. However, the cost-effectiveness population-based setting >3 rounds is uncertain. Therefore, objective of this study was to estimate Ontario, Canada, evaluate effects eligibility criteria. Methods Findings This used microsimulation modeling informed by various data sources,...
Implementing optimal lung cancer screening programs requires knowledge of the natural history and detectability cancer. This information can be derived from results clinical trials with aid microsimulation models.Data Surveillance, Epidemiology, End Results (SEER) program individual-level data National Lung Screening Trial (NLST) Prostate, Lung, Colon, Ovarian Cancer trial (PLCO) were used to investigate sensitivity (by histology stage) CT chest radiography (CXR) mean preclinical sojourn...
Background: Recommendations vary regarding the maximum age at which to stop lung cancer screening: 80 years according U.S. Preventive Services Task Force (USPSTF), 77 Centers for Medicare & Medicaid (CMS), and 74 National Lung Screening Trial (NLST). Objective: To compare cost-effectiveness of different stopping ages screening. Design: By using shared inputs smoking behavior, costs, quality life, 4 independently developed microsimulation models evaluated health cost outcomes annual screening...
Rationale: The level of adherence to lung cancer treatment guidelines in the United States is unclear. In addition, it unclear whether previously identified disparities by racial or ethnic group and age persist across all clinical subgroups.Objectives: To assess minimal recommended National Comprehensive Cancer Network (guideline-concordant treatment) States, persistence subgroups.Methods: We evaluated 441,812 cases Database diagnosed between 2010 2014 received guideline-concordant...
Low-dose computed tomography lung cancer screening is most effective when applied to high-risk individuals.To develop and validate a risk prediction model that incorporates low-dose results.A logistic regression was developed in National Lung Screening Trial (NLST) Study (LSS) data validated NLST American College of Radiology Imaging Network (ACRIN) data. The randomized clinical trial recruited participants between August 2002 April 2004, with follow-up December 31, 2009. This secondary...
Abstract Background Risk-prediction models have been proposed to select individuals for lung cancer screening. However, their long-term effects are uncertain. This study evaluates benefits and harms of risk-based screening compared with current United States Preventive Services Task Force (USPSTF) recommendations. Methods Four independent natural history were used perform a comparative modeling evaluating selecting through risk-prediction models. In total, 363 strategies varying by starting...
In their 2021 lung cancer screening recommendation update, the U.S. Preventive Services Task Force (USPSTF) evaluated strategies that select people based on personal risk (risk model-based strategies), highlighting need for further research benefits and harms of screening.
The revised 2021 US Preventive Services Task Force (USPSTF) guidelines for lung cancer screening have been shown to reduce disparities in eligibility and performance between African American White individuals vs the 2013 guidelines. However, potential across other racial ethnic groups remain unknown. Risk model-based may improve performance, but neither validation of key risk prediction models nor their has examined by race ethnicity.
BACKGROUND The National Lung Screening Trial (NLST) demonstrated that low‐dose computed tomography screening is an effective way of reducing lung cancer (LC) mortality. However, optimal strategies have not been determined to date and it uncertain whether lighter smokers than those examined in the NLST may also benefit from screening. To address these questions, necessary first develop LC natural history models can reproduce outcomes simulate programs at population level. METHODS Five...
Abstract Background Current US Preventive Services Task Force (USPSTF) lung cancer screening guidelines are based on smoking history and age (55–80 years). These may miss those at higher risk, even lower exposures of or younger ages, because other risk factors such as race, family history, comorbidity. In this study, we characterized the demographic clinical profiles selected by risk-based criteria but were missed USPSTF in (50–54 years) older (71–80 groups. Methods We used data from...
<h3>Importance</h3> The US Preventive Services Task Force (USPSTF) issued its 2021 recommendation on lung cancer screening, which lowered the starting age for screening from 55 to 50 years and minimum cumulative smoking exposure 30 20 pack-years relative 2013 recommendation. Although costs are expected increase because of expanded eligibility criteria, it is unknown whether new guidelines cost-effective. <h3>Objective</h3> To evaluate cost-effectiveness USPSTF compared with explore 6...
<h3>Background</h3> Debate about the optimal lung cancer screening strategy is ongoing. In this study, previous history of Dutch-Belgian Lung Cancer Screening trial (NELSON) investigated on if it predicts outcome (test result and risk) final round. <h3>Methods</h3> 15 792 participants were randomised (1:1) which 7900 into a group. CT took place at baseline, after 1, 2 2.5 years. Initially, three outcomes possible: negative, indeterminate or positive scan result. Probability for in fourth...