A5072254367- Health Systems, Economic Evaluations, Quality of Life
- Neutropenia and Cancer Infections
- Atrial Fibrillation Management and Outcomes
- Pharmaceutical Practices and Patient Outcomes
- Economic and Financial Impacts of Cancer
- Cancer Treatment and Pharmacology
- Meta-analysis and systematic reviews
- Blood disorders and treatments
- Chronic Disease Management Strategies
- Colorectal Cancer Treatments and Studies
- Influenza Virus Research Studies
- Breast Cancer Treatment Studies
- Medication Adherence and Compliance
- Healthcare Policy and Management
- Pharmaceutical Economics and Policy
- Lung Cancer Treatments and Mutations
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Ethics in Clinical Research
- Iron Metabolism and Disorders
- Cardiac Arrhythmias and Treatments
- Heart Failure Treatment and Management
- Healthcare cost, quality, practices
- Venous Thromboembolism Diagnosis and Management
- Advanced Breast Cancer Therapies
University of Basel
2016-2025
University of Zurich
2016-2025
University Hospital of Basel
2007-2022
Hospital Base
2022
Swiss Tropical and Public Health Institute
2022
Prevention Institute
2021-2022
University Hospital of Zurich
2000-2022
Careers Europe
2021
Kantonsspital Graubünden
2021
National Cancer Registration Service
2021
<h3>Importance</h3> The discontinuation of randomized clinical trials (RCTs) raises ethical concerns and often wastes scarce research resources. epidemiology discontinued RCTs, however, remains unclear. <h3>Objectives</h3> To determine the prevalence, characteristics, publication history RCTs to investigate factors associated with RCT due poor recruitment nonpublication. <h3>Design Setting</h3> Retrospective cohort based on archived protocols approved by 6 ethics committees in Switzerland,...
Abstract Objective To examine the effect of optimising drug treatment on related hospital admissions in older adults with multimorbidity and polypharmacy admitted to hospital. Design Cluster randomised controlled trial. Setting 110 clusters inpatient wards within university based hospitals four European countries (Switzerland, Netherlands, Belgium, Republic Ireland) defined by attending doctors. Participants 2008 (≥70 years) (≥3 chronic conditions) (≥5 drugs used long term). Intervention...
The Prospective Oral Mucositis Audit assessed the incidence, duration, and determinants of severe oral mucositis (OM; WHO toxicity scale grades 3 to 4) in patients with multiple myeloma (MM) or non-Hodgkin's lymphoma (NHL) receiving high-dose conditioning chemotherapy before autologous stem-cell transplantation.Patients MM (n = 109; mean age, 57 +/- 8 years) NHL 88; 50 13 were treated melphalan (200 mg/m(2)) carmustine 300 mg/m(2), etoposide 800 cytarabine 1,600 140 mg/m(2) chemotherapy,...
Abstract Background The objectives of the survey were to identify level influenza vaccination coverage in five European countries between 2001 and 2007, understand drivers barriers vaccination, assess intentions for winter 2007/08 as well major encouraging factors vaccination. Methods Between representative household surveys performed with telephone or mailed (France) interviews individuals aged 14 above. questionnaire used UK, Germany, Italy, France Spain was essentially same all seasons....
Patient ratings of satisfaction with their postoperative pain treatment tend to be high even in those substantial pain. Determinants are poorly understood and have not previously been studied large-scale, international datasets. PAIN OUT, a European Union-funded acute registry research project, collects patient-reported outcome data on day 1 using the self-reported International Pain Outcome Questionnaire (IPO), patient, clinical, characteristics. We investigated correlates consistency...
Abstract Aims We aimed to investigate the association of clinically overt and silent brain lesions with cognitive function in atrial fibrillation (AF) patients. Methods results enrolled 1227 AF patients a prospective, multicentre cohort study (Swiss-AF). Patients underwent standardized magnetic resonance imaging (MRI) at baseline after 2 years. quantified new small non-cortical infarcts (SNCIs) large or cortical (LNCCIs), white matter (WML), microbleeds (Mb). Clinically, were defined as...
To study the effects of a primary care medication review intervention centred around an electronic clinical decision support system (eCDSS) on appropriateness and number prescribing omissions in older adults with multimorbidity polypharmacy compared discussion about line usual care.Cluster randomised trial.Swiss care, between December 2018 February 2021.Eligible patients were ≥65 years age three or more chronic conditions five long term medications.The to optimise pharmacotherapy eCDSS was...
Neutropenia is a life-threatening, dose-limiting toxicity of many chemotherapy regimens. The goals this study were to assess the incidence and risk chemotherapy-induced neutropenia, febrile neutropenia (FN) dose limitations in breast cancer lymphoma patients undergoing Europe. Four hundred forty-four 305 at 66 practices five European countries participated prospective, observational study. Predictors impaired delivery investigated using logistic regression model. In cancer, FN was low (6%);...
Chemotherapy dose delay and/or reduction lower relative total intensity (RTDI) and may affect short- long-term outcome of metastatic breast cancer (MBC) patients. Based on 933 individual patients' data from 3 randomized MBC trials using an anthracycline taxane we examined the impact RTDI efficacy determined lowest optimal for Median time to disease progression (TTDP) overall survival (OS) all patients were 39 98 weeks. Overall higher was correlated with a shorter TTDP (log-rank p = 0.0525...
Myelosuppression, particularly febrile neutropenia (FN), are serious dose-limiting toxicities that occur frequently during the first cycle of chemotherapy. Identifying patients most at risk developing FN might help physicians to target prophylactic treatment with colony-stimulating factor (CSF), in order decrease incidence, or duration, myelosuppression and facilitate delivery chemotherapy as planned. We present a model for occurrence chemotherapy, based on subgroup 240 non-Hodgkin lymphoma...
To investigate the planning of subgroup analyses in protocols randomised controlled trials and agreement with corresponding full journal publications.Cohort trial subsequent publications.Six research ethics committees Switzerland, Germany, Canada.894 involving patients approved by participating between 2000 2003 515 publications.Of 894 trials, 252 (28.2%) included one or more planned analyses. Of those, 17 (6.7%) provided a clear hypothesis for at least analysis, 10 (4.0%) anticipated...
Several studies found that patients with atrial fibrillation (AF) have an increased risk of cognitive decline and dementia over time. However, the magnitude problem, associated factors underlying mechanisms remain unclear.This article describes design methodology Swiss Atrial Fibrillation (Swiss-AF) Cohort Study, a prospective multicentre national cohort study 2400 across 13 sites in Switzerland. Eligible must documented AF. Main exclusion criteria are inability to provide informed consent...
Background The incidence and predictors of atrial fibrillation ( AF ) progression are currently not well defined, clinical partly overlaps with rhythm control interventions RCI s). Methods Results We assessed type intercurrent s during yearly follow‐ups in 2869 prospectively followed patients paroxysmal or persistent . Clinical was defined as from to nonparoxysmal permanent An pulmonary vein isolation, electrical cardioversion, new treatment amiodarone. During a median follow‐up 3 years, the...
Background We previously found that 25% of 1,017 randomized clinical trials (RCTs) approved between 2000 and 2003 were discontinued prematurely, 44% remained unpublished at a median 12 years follow-up. aimed to assess decade later (1) whether rates completion publication have increased; (2) the extent which nonpublished RCTs can be identified in trial registries; (3) association reporting quality protocols premature discontinuation or nonpublication RCTs. Methods findings included 326 RCT...