A5027146585- Nutrition, Genetics, and Disease
- Anesthesia and Pain Management
- Nutritional Studies and Diet
- BRCA gene mutations in cancer
- Pain Management and Opioid Use
- Cancer Risks and Factors
- Cardiac Arrest and Resuscitation
- Cardiac, Anesthesia and Surgical Outcomes
- Musculoskeletal pain and rehabilitation
- Neuropeptides and Animal Physiology
- Contact Dermatitis and Allergies
- Cancer Genomics and Diagnostics
- Cancer, Stress, Anesthesia, and Immune Response
- Cardiovascular Health and Risk Factors
- Olfactory and Sensory Function Studies
- Fatty Acid Research and Health
- Genetic factors in colorectal cancer
- Trauma and Emergency Care Studies
- Diet and metabolism studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Emergency and Acute Care Studies
- Dermatology and Skin Diseases
- Respiratory Support and Mechanisms
- Nausea and vomiting management
- Stuttering Research and Treatment
Leipzig University
2014-2024
Life University
2017
University Hospital Leipzig
2015
Patient ratings of satisfaction with their postoperative pain treatment tend to be high even in those substantial pain. Determinants are poorly understood and have not previously been studied large-scale, international datasets. PAIN OUT, a European Union-funded acute registry research project, collects patient-reported outcome data on day 1 using the self-reported International Pain Outcome Questionnaire (IPO), patient, clinical, characteristics. We investigated correlates consistency...
Health benefits of the Mediterranean Diet (MD) have been shown in different at-risk populations. A German translation Adherence Screener (MEDAS) from PREvención con DIeta MEDiterránea (PREDIMED) consortium was used LIBRE study, investigating effects lifestyle-intervention on women with BRCA1/2 mutations. The purpose present study is to validate MEDAS version. a multicentre (three university hospitals during this pilot phase), unblinded, randomized, controlled clinical trial. Women mutation...
The aim of this study was to determine simple risk factors for severe pain intensity (≥7 points on a numeric rating scale [NRS]), analyse their relation other patient-reported outcome measures and develop prediction model.We used data from 50,005 patients the PAIN-OUT project. Within first set (n = 33,667), relevant were identified by logistic binary regression analysis, assessed additional beyond summed up developing score. Finally, sum plotted against postoperative outcomes within...
Journal Article Cohort Profile: The LIFE-Adult-Study Get access Christoph Engel, Engel Institute for Medical Informatics, Statistics and Epidemiology, Leipzig University, Leipzig, GermanyLeipzig Research Centre Civilization Diseases, Germany Corresponding author. Haertelstrasse 16–18, 04107 Germany. E-mail: christoph.engel@imise.uni-leipzig.de https://orcid.org/0000-0002-7247-282X Search other works by this author on: Oxford Academic PubMed Google Scholar Kerstin Wirkner, Wirkner Samira...
Background Management of critically ill nontrauma (CINT) patients in the resuscitation room (RR) emergency department (ED) is very challenging. Detailed data describing characteristics and management this population are lacking. This observational study describes epidemiology, outcome CINT ED RR. Patients methods From September 2014 to August 2015, were collected prospectively on adult admitted RR a single German University ED. Patient characteristics, out-of-hospital/in-hospital treatment,...
Current literature is in disagreement regarding female sex as a risk factor for pain after surgery. We hypothesized, that differences exist but they are influenced by certain factors. Here, we investigated the influence of different clinically relevant postoperative (POP) outcome parameters and evaluated role assumed confounders differences.From 1372 screened patients undergoing orthopedic surgery at university hospital Muenster between March 2010 June 2011, 890 were included. The validated...
Adherence to the Mediterranean diet is associated with beneficial health effects, including gastrointestinal disorders. Preclinical studies suggest that omega-3 polyunsaturated fatty acids (n-3 PUFAs), found in foods like nuts and fish, improve intestinal barrier integrity. Here, we assessed possible effects of n-3 PUFAs on integrity a randomized controlled trial.We studied 68 women from open-label LIBRE trial (clinicaltrials.gov: NCT02087592) who followed either (intervention group, IG) or...
Studies in older adults or those with cognitive impairment have shown associations between and olfactory performance, but there are few population-based studies especially younger adults. We therefore cross-sectionally analyzed this association using data from the LIFE-Adult-Study. Cognitive assessments comprised tests Consortium to Establish a Registry for Alzheimer's Disease (CERAD): verbal fluency (VF), word list learning recall (WLL, WLR), Trail Making Tests (TMT) A B. The "Sniffin'...
Women with highly penetrant BRCA mutations have a 55–60 % lifetime risk for breast cancer and 16–59 of developing ovarian cancer. However, penetrance differs interindividually, indicating that environmental behavioral factors may modify this risk. It is well documented the sporadic disease can be modified by changing lifestyle primarily include physical activity, dietary habits, body weight. thus hypothesized modification these also influence incidence progression in mutation carriers. This...
Emergency airway management (AM) is a major key for successful resuscitation of critically ill non-traumatic (CINT) patients. Details the AM these patients in German emergency departments (ED) are unknown. This observational study describes epidemiology, techniques, success rates and complications CINT ED room (RR). Data was collected prospectively on adult admitted to RR single university September 2014 August 2015. Patient characteristics, out-of-hospital in-hospital AM, were recorded...
There is a lack of epidemiological data on allergies to dental materials. For example, in the recently published fifth German Oral Health Study (DMS V), no information was given any common or The aim present observational study therefore determine frequencies and symptoms A public consultation hour for oral mucosa material incompatibilities has been integrated Department Dental Prosthodontics Materials Science Leipzig, where clinical patient have systematically collected since 2012....
Women with pathogenic BRCA germline mutations have an increased risk for breast and ovarian cancer that seems to be modified by life-style factors. Though, randomized trials investigating the impact of lifestyle interventions on prevention prognosis in carriers are still missing.We implemented a multicenter, prospective controlled trial BRCA1/2 patients, comparing intervention group (IG) control (CG) primary aim prove feasibility. Intervention comprised structured, individualized endurance...
Research shows a connection between stress and depression, but there is little differentiation areas of stress, making it difficult to identify address specific in the context public health measures. We utilized multi-dimensional approach chronic better understand relationship different depression.We conducted linear regression analyses used data from sub-sample LIFE-Adult-Study (N = 1008) analyze nine (TICS) depression (CES-D). In second analysis, we controlled for sociodemographic...
Abstract Rationale, aims and objectives Management of post‐operative pain is unsatisfactory worldwide. An estimated 240 million patients undergo surgery each year. Forty to 60% these report clinically significant pain. Discrepancy exists between availability evidence‐based medicine ( EBM )‐derived knowledge about management perioperative increased implementation related practices versus lack improvement in patient‐reported outcomes PROs ). We aimed assist health care providers optimize by...
Exfoliative cytology performed on oral brush samples can help dentists to decide, whether a given lesion is (pre-) malignant. The use of non-invasive biopsies as an auxiliary tool in the diagnosis mucosal lesions has gained renewed interest since improvements cytological techniques such development adjuvant diagnostic tools and liquid-based cell preparation techniques. aim this study was compare quality two different (cell collectors): conventional transfer procedure glass slides so-called...
Purpose: To describe and compare primary patency rates in patients undergoing endovascular femoropopliteal interventions with standard or interwoven nitinol stents drug-coated balloons. Methods: A cohort of 1292 was treated for symptomatic occlusive disease classified as Rutherford category ≥1 at a large vascular center between June 2006 August 2013 using either (SNS; n=432), (INS; n=470), balloons (DCB; n=390). Primary were assessed by ultrasound angiographic readings over 3 years...
Women with highly penetrant BRCA mutations have a 55–60% lifetime risk for breast cancer and 16–59% ovarian cancer. However, penetrance differs interindividually, indicating that environmental behavioral factors may modify this risk. These include lifestyle such as physical activity status, dietary habits, body weight. The modification of by changing has not thus far been investigated in randomized trial mutation carriers. Therefore, we intend to enroll 60 BRCA1/2 carriers pilot feasibility...
SIGNIFICANCE Increasing prevalence of refractive error requires assessment ametropia as a screening tool in children. If cycloplegia is not an option, knowledge about the increase uncertainty for wavefront-based autorefraction needed. The cycloplegic agent principal variant presents cross-reference and allows extraction influence accommodation. PURPOSE purpose this study was to determine repeatability, agreement, propensity accommodate (ARc) noncycloplegic (ARnc) (ZEISS i.Profiler plus; Carl...
Coronary heart disease, an inflammatory is the leading cause of death globally. White blood cell counts (including monocytes) are easily available biomarkers systemic inflammation. Monocyte subtypes can be measured by flow cytometry and classified into classical (CD14high, CD16neg), intermediate CD16+) non-classical (CD14+, CD16high) with distinct functional properties. The goal this study was to investigate association monocyte total count its cardiovascular risk groups defined Framingham...
Currently, there is minimal clinical data regarding biofilm composition on the surface of denture bases and tissue compatibility. Therefore, aim this experimental study was to compare bacterial colonization compatibility a hypoallergenic polyamide with frequently used PMMA resin tested intraorally in randomized split-mouth design. Test specimens made (n = 10) were attached over molar band appliance oral cavity 10 subjects. A cytological smear test done from palatal mucosa at baseline after...