A5012026757- Mental Health Research Topics
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Mind wandering and attention
- Stress Responses and Cortisol
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neural dynamics and brain function
- Heart Rate Variability and Autonomic Control
- Blood Pressure and Hypertension Studies
- Hemispheric Asymmetry in Neuroscience
- Health disparities and outcomes
- Neural and Behavioral Psychology Studies
- Tryptophan and brain disorders
- Cardiac Health and Mental Health
- Cerebrovascular and Carotid Artery Diseases
- Morphological variations and asymmetry
- Cardiovascular Health and Disease Prevention
- Health, Environment, Cognitive Aging
- EEG and Brain-Computer Interfaces
- Cardiovascular Health and Risk Factors
- Birth, Development, and Health
- Creativity in Education and Neuroscience
- Attention Deficit Hyperactivity Disorder
- Perfectionism, Procrastination, Anxiety Studies
- Memory and Neural Mechanisms
Max Planck Institute for Human Cognitive and Brain Sciences
2016-2025
Heinrich Heine University Düsseldorf
2022-2025
Düsseldorf University Hospital
2024-2025
Max Planck Society
2013-2023
Forschungszentrum Jülich
2021-2023
Brain (Germany)
2021-2023
Institute of Neurobiology and Molecular Medicine
2019-2022
University of Haifa
2019
Abstract We present a publicly available dataset of 227 healthy participants comprising young (N=153, 25.1±3.1 years, range 20–35 45 female) and an elderly group (N=74, 67.6±4.7 59–77 37 acquired cross-sectionally in Leipzig, Germany, between 2013 2015 to study mind-body-emotion interactions. During two-day assessment, completed MRI at 3 Tesla (resting-state fMRI, quantitative T1 (MP2RAGE), T2-weighted, FLAIR, SWI/QSM, DWI) 62-channel EEG experiment rest. task-free resting-state...
Abstract Multiple studies have reported a link between mental health and high blood pressure with mixed or even contradictory findings. Here, we resolve those contradictions further dissect the cross-sectional longitudinal relationship health, systolic pressure, hypertension using extensive psychological, medical neuroimaging data from UK Biobank. We show that higher is associated fewer depressive symptoms, greater well-being, lower emotion-related brain activity. Interestingly, impending...
Abstract The dataset enables exploration of higher-order cognitive faculties, self-generated mental experience, and personality features in relation to the intrinsic functional architecture brain. We provide multimodal magnetic resonance imaging (MRI) data a broad set state trait phenotypic assessments: mind-wandering, traits, abilities. Specifically, 194 healthy participants (between 20 75 years age) filled out 31 questionnaires, performed 7 tasks, reported 4 probes in-scanner...
Journal Article Cohort Profile: The LIFE-Adult-Study Get access Christoph Engel, Engel Institute for Medical Informatics, Statistics and Epidemiology, Leipzig University, Leipzig, GermanyLeipzig Research Centre Civilization Diseases, Germany Corresponding author. Haertelstrasse 16–18, 04107 Germany. E-mail: christoph.engel@imise.uni-leipzig.de https://orcid.org/0000-0002-7247-282X Search other works by this author on: Oxford Academic PubMed Google Scholar Kerstin Wirkner, Wirkner Samira...
The human cerebral cortex is symmetrically organized along large-scale axes but also presents inter-hemispheric differences in structure and function. quantified contralateral homologous difference, that asymmetry, a key feature of the brain left-right axis supporting functional processes, such as language. Here, we assessed whether asymmetry cortical organization heritable phylogenetically conserved between humans macaques. Our findings indicate asymmetric an describing trajectory from...
To test whether elevated blood pressure (BP) relates to gray matter (GM) volume (GMV) changes in young adults who had not previously been diagnosed with hypertension (systolic BP [SBP]/diastolic [DBP] ≥140/90 mm Hg).We associated GMV from structural 3T T1-weighted MRI of 423 healthy between 19 and 40 years age (mean 27.7 ± 5.3 years, 177 women, SBP/DBP 123.2/73.4 12.2/8.5 Hg). Data originated 4 unpublished cross-sectional studies conducted Leipzig, Germany. We performed voxel-based...
Abstract Determining sex-bias in brain structure is of great societal interest to improve diagnostics and treatment brain-related disorders. So far, studies on predominantly focus macro-scale measures, often ignore factors determining this bias. Here we study cortical hippocampal microstructure relation sex hormones. Investigating quantitative intracortical profiling in-vivo using the T1w/T2w ratio 1093 healthy females males cross-sectional Human Connectome Project young adult sample, find...
Abstract The human thalamus is a heterogeneous subcortical structure coordinating whole-brain activity. Investigations of its internal organization reveal differentiable subnuclei, however, consensus on subnuclei boundaries remains absent. Recent work suggests that thalamic additionally reflects continuous axes transcending nuclear boundaries. Here, we study how low-dimensional thalamocortical structural connectivity relate to intrathalamic microstructural features, functional connectivity,...
This study investigated the neural regions involved in blood pressure reactions to negative stimuli and their possible modulation by attention. Twenty-four healthy human subjects (11 females; age = 24.75 ± 2.49 years) participated an affective perceptual load task that manipulated attention negative/neutral distractor pictures. fMRI data were collected simultaneously with continuous recording of peripheral arterial pressure. A parametric analysis examined impact emotion on relation between...
The hippocampus is a uniquely infolded allocortical structure in the medial temporal lobe that consists of microstructurally and functionally distinct subregions: subiculum, cornu ammonis, dentate gyrus. remarkably plastic region implicated learning memory. At same time it has been shown hippocampal subregion volumes are heritable, genetic expression varies along posterior to anterior axis. Here, we studied how stable, organisation may support its flexible function healthy adults. Leveraging...
Cognitive abilities and affective experience are key human traits that interrelated in behavior brain. Individual variation of cognitive traits, as well brain structure, has been shown to partly underlie genetic effects. However, what extent affect cognition have a shared relationship with local structure is incompletely understood. Here we studied phenotypic correlations (cortical thickness, surface area subcortical volumes) the pedigree-based Human Connectome Project sample (N = 1091)....
Abstract Background Cumulative burden from vascular risk factors (VRFs) has been associated with an increased of depressive symptoms in mid- and later life. It hypothesised that this association arises because VRFs disconnect fronto-subcortical white matter tracts involved mood regulation, which puts older adults at higher developing symptoms. However, evidence for the hypothesis disconnection underlies between VRF longitudinal studies is scarce. Methods This preregistered study analysed...
Abstract Objectives Cumulative burden of vascular risk factors (VRFs) has been linked to an increased depressed mood. However, the role age in this association is still unclear. Here, we investigated whether VRF associated with levels and changes mood these associations become stronger or weaker from mid- later life. Method We used longitudinal data 5,689 participants (52–89 years) English Longitudinal Study Ageing. A composite score incorporated presence 5 VRFs: hypertension, diabetes,...
Abstract The human thalamus is a bilateral and heterogeneous grey matter structure that plays crucial role in coordinating whole-brain activity. Investigations of its complex structural functional internal organization revealed to certain degree overlapping parcellations, however, consensus on thalamic subnuclei boundaries remains absent. Recent work suggests might additionally reflect continuous axes transcending nuclear boundaries. In this study, we used multimodal approach uncover how...
Complex macro-scale patterns of brain activity that emerge during periods wakeful rest provide insight into the organisation neural function, how these differentiate individuals based on their traits, and basis different types self-generated thoughts. Although is valuable for understanding important features human cognition, its unconstrained nature makes it difficult to disentangle related personality traits from those thoughts occurring at rest. Our study builds recent perspectives work...
Abstract While macroscale brain asymmetry and its relevance for human cognitive function have been consistently shown, the underlying neurobiological signatures remain an open question. Here, we probe layer-specific microstructural of cortex using intensity profiles from post-mortem cytoarchitecture. An anterior-posterior cortical pattern left-right was found, varying across layers. A similar observed in vivo imaging, with showing strongest similarity layer III. Microstructural varied as a...
Complex macro-scale patterns of brain activity that emerge during periods wakeful rest provide insight into the organisation neural function, how these differentiate individuals based on their traits, and basis different types self-generated thoughts. Although is valuable for understanding important features human cognition, its unconstrained nature makes it difficult to disentangle related personality traits from those thoughts occurring at rest. Our study builds recent perspectives work...
Abstract The human cerebral cortex shows hemispheric asymmetry, yet the microstructural basis of this asymmetry remains incompletely understood. Here, we probe layer-specific using one post-mortem male brain. Overall, anterior and posterior regions show leftward rightward respectively, but pattern varies across cortical layers. A similar anterior-posterior is observed in vivo Human Connectome Project ( N = 1101) T1w/T2w data, with average showing strongest similarity -based layer III....
The topological differentiation of sensorimotor and association cortical regions along a sensorimotor-association (S-A) axis has undergone profound evolutionary change the mammalian lineage. In humans, patterns gene expression, microstructure, functional connectivity have been shown to vary systematically such S-A axis. Despite robust spatial relationships between these different neurobiological traits, whether common genetic pressures shape across traits remains poorly understood. this...
Complex macro-scale patterns of brain activity that emerge during periods wakeful rest provide insight into the organisation neural function, how these differentiate individuals based on their traits, and basis different types self-generated thoughts. Although is valuable for understanding important features human cognition, its unconstrained nature makes it difficult to disentangle related personality traits from those thoughts occurring at rest. Our study builds recent perspectives work...
Stress is an important trigger for brain plasticity: Acute stress can rapidly affect activity and functional connectivity, chronic or pathological has been associated with structural changes. Measures of magnetic resonance imaging (MRI) be modified by short-term motor learning visual stimulation, suggesting that they also capture rapid Here, we investigated volumetric changes (together in T1 relaxation rate cerebral blood flow) after acute humans as well their relation to psychophysiological...
Abstract The dataset enables exploration of higher-order cognitive faculties, self-generated mental experience, and personality features in relation to the intrinsic functional architecture brain. We provide multimodal magnetic resonance imaging (MRI) data a broad set state trait phenotypic assessments: mind-wandering, traits, abilities. Specifically, 194 healthy participants (between 20 75 years age) filled out 31 questionnaires, performed 7 tasks, reported 4 probes in-scanner...
Abstract Objective To test whether elevated blood pressure (BP) relates to grey matter volume (GMV) changes in young adults who had not previously been diagnosed as hypertensive (systolic BP (SBP)/diastolic (DBP)≥140/90 mmHg). Methods We associated with GMV from structural 3 Tesla T1-weighted MRI of 423 healthy between 19-40 years (mean age=27.7±5.3 years, 177 women, SBP/DBP=123.2/73.4±12.2/8.5 Data originated four unpublished cross-sectional studies conducted Leipzig, Germany. performed...