A5011068135- Dementia and Cognitive Impairment Research
- Health disparities and outcomes
- Aging and Gerontology Research
- Geriatric Care and Nursing Homes
- Workplace Health and Well-being
- Employment and Welfare Studies
- Health, Environment, Cognitive Aging
- Functional Brain Connectivity Studies
- COVID-19 and Mental Health
- Retinal Imaging and Analysis
- Cognitive Functions and Memory
- Intergenerational Family Dynamics and Caregiving
- Cognitive Abilities and Testing
- Health, psychology, and well-being
- Health and Medical Studies
- Creativity in Education and Neuroscience
- Mental Health Research Topics
- Music Therapy and Health
- Musculoskeletal pain and rehabilitation
- Health Systems, Economic Evaluations, Quality of Life
- Retirement, Disability, and Employment
- Glaucoma and retinal disorders
- Intensive Care Unit Cognitive Disorders
- Neuroscience and Music Perception
- Neurobiology of Language and Bilingualism
German Center for Neurodegenerative Diseases
2018-2025
Leipzig University
2017-2024
Universitätsmedizin Greifswald
2020-2023
University of Kaiserslautern
2018-2022
Institute on Aging
2017-2020
University of Southern California
2017-2020
Bethel University
2020
Ruhr University Bochum
2020
Workplace Health, Safety and Compensation Commission
2020
University of Cologne
2018
Journal Article Cohort Profile: The LIFE-Adult-Study Get access Christoph Engel, Engel Institute for Medical Informatics, Statistics and Epidemiology, Leipzig University, Leipzig, GermanyLeipzig Research Centre Civilization Diseases, Germany Corresponding author. Haertelstrasse 16–18, 04107 Germany. E-mail: christoph.engel@imise.uni-leipzig.de https://orcid.org/0000-0002-7247-282X Search other works by this author on: Oxford Academic PubMed Google Scholar Kerstin Wirkner, Wirkner Samira...
Knowledge on the link of individual social deprivation with dementia is incomplete. We thus aimed to see whether an association risk can be observed using a recently developed Social Deprivation Index (SoDep Index). Further, as related depression, we investigated role depression in association.We analysed data 11 623 Survey Health, Ageing and Retirement Europe (SHARE) respondents. status was determined by SoDep score. Dementia self-reported diagnosis. estimated Cox proportional hazard...
The outbreak of the Corona virus is a challenge for health care systems worldwide. aim this study to analyze a) knowledge about, and feelings related Corona-pandemic. Describe b) loneliness, depression anxiety and, c) perceived, immediate impact lockdown on frequency social contacts quality provision people with cognitive impairment during distancing in primary system living at home Germany.This analysis based data telephone-based assessment convenience sample n = 141 known setting. Data...
Social interactions can have a beneficial effect on people with dementia (PWD). However, little is known about the details of social in dementia, information that useful for planning interventions. The aim our study was to gain deeper insight, provided by care, into (i) characteristics PWD, (ii) which are considered as particularly important, (iii) how important perceived, and (iv) what perceived increase among PWD. Responses 501 care (mostly family professional caregivers; more than...
<b><i>Background:</i></b> The capacity to mitigate dementia symptomology despite the prevailing brain pathology has been attributed cognitive reserve. <b><i>Objectives:</i></b> This study aimed investigate how psychometric performance differs between individuals with a high school versus college education (surrogate measures for medium and reserves) given same level of assessed using quantitative structural MRI....
Abstract Objectives Previous studies have shown that higher education promotes cognitive health. This effect, however, is embedded in the living conditions of a particular country. Since it not clear to what extent country and its specific standards are necessary preconditions for observed we investigated whether impact income on functioning differs between countries. Methods Analyses were based harmonized data from World Health Organization's multi‐country Study global AGEing adult health,...
Abstract Objective Interventions to reduce the risk of cognitive decline and dementia largely focus on individual‐level strategies. To maximize reduction, it is also necessary consider environment. With majority older people living in cities, we explored how urban environments could support reduction. Materials Methods In our qualitative study, conducted semi‐structured interviews with community members aged ≥65 years stakeholders, all Leipzig, Germany. Interview guides were informed by...
Abstract Background It is well known that older age associated with losses in cognitive functioning. Less about the extent to which creativity changing or dementia. Aim of current study was gain more insights into psychometric aspects younger and people as Method Our sample comprised three groups, (1) participants between 18—30 years ( n = 24), (2) 65 + without impairment (3) / dementia 23). Cognitive abilities were assessed via Standard Progressive Matrices Test (SPM) , Montreal Assessment...
Purpose Investigating demands within an occupational context has always been essential endeavor to guarantee worker well-being and performance efficiency. In blue-collar occupations, the physical of manual labor have major focus, but recent technological changes may come with higher on intellectual capacities workers. For this reason, purpose paper is assess cognitive that construction workers face. Design/methodology/approach The authors conducted a quantitative study using standardized...
Mild cognitive impairment (MCI) is considered a pre-stage of different dementia syndromes. Despite diagnostic criteria refined by DSM-5 and new term for MCI - "mild neurocognitive disorder" (mild NCD) this diagnosis still based on clinical criteria.To link mild NCD to the underlying pathophysiology we assessed degree white matter hyperintensities (WMH) in brain peripheral biomarkers neuronal integrity (neuron-specific enolase, NSE), plasticity (brain-derived neurotrophic factor, BDNF), glial...
Abstract Background The aim of this study was to investigate the role support from social environment for life expectancy in people with dementia beyond well-established individual demographic and clinical predictors over a period up 8 years. Methods analyses are based on data 500 community-dwelling individuals Germany who tested positive were followed Life examined relation perceived as well socio-demographic (age, sex) (cognitive status, functional comorbidities), using Cox regressions....
To provide new age-, sex-, and education-specific reference values for an extended version of the well-established Consortium to Establish a Registry Alzheimer's Disease Neuropsychological Assessment Battery (CERAD-NAB) that additionally includes Trail Making Test Verbal Fluency Test-S-Words.Norms were calculated based on cognitive performances n = 1,888 dementia-free participants (60-79 years) from population-based German LIFE-Adult-Study. Multiple regressions used examine association...
Subjectively perceived memory problems (memory-related Subjective Cognitive Symptoms/SCS) can be an indicator of a pre-prodromal or prodromal stage neurodegenerative disease such as Alzheimer's disease. We therefore sought to provide detailed empirical information on memory-related SCS in the dementia-free adult population including prevalence rates, associated factors and others. studied 8834 participants (40–79 years) population-based LIFE-Adult-Study. Weighted rates with confidence...
Several lifestyle factors promote protection against Alzheimer's disease (AD) throughout a person's lifespan. Although such protective effects have been described for occupational cognitive requirements (OCR) in midlife, it is currently unknown whether they are conveyed by brain maintenance (BM), reserve (BR), or (CR) combination of them.We systematically derived hypotheses these resilience concepts and tested them the population-based AgeCoDe cohort memory clinic-based AD high-risk DELCODE...
Completion of advance directives (ADs) and power attorney (POA) documents may protect a person's autonomy in future health care situations when the individual lacks decisional capacity. As such become naturally much more common old age, we specifically aimed at providing information on (i) frequency ADs/POA oldest-old individuals (ii) factors associated with having completed ADs/POA.We analyzed data primary patients (85+ years; including community-dwelling institutionalized individuals)...
Lack of social support has shown to be a major risk factor for poor health, mortality, and dementia. We analyzed what factors drive the likelihood having restricted networks extent those then influence developing Our results from Leipzig Longitudinal Study Aged (LEILA75+) indicate that older age (odds ratio [OR]: 1.04) living with other people (OR: 2.12) was associated greater network. A better cognitive status 0.84) smaller The dementia over follow-up period significantly higher among...
Abstract Objectives Social deprivation, i.e. the relative deprivation in socioeconomic domains, is known to exacerbate disease risk. Less about its role cognitive functioning and decline older adults. This study aimed investigate association between social status as well rate of decline. Methods We analysed data from nationally representative Health Retirement (HRS) individuals aged 50 older. The analysis sample contained 11,101 respondents (mean age at baseline: 69.4, SD: 8.6%, 55% female)...