A5048113405- Dementia and Cognitive Impairment Research
- Metabolism and Genetic Disorders
- Health disparities and outcomes
- Health and Medical Studies
- Chronic Disease Management Strategies
- Diet and metabolism studies
- Frailty in Older Adults
- Health Systems, Economic Evaluations, Quality of Life
- Amino Acid Enzymes and Metabolism
- Geriatric Care and Nursing Homes
- Psychiatric care and mental health services
- Biomedical Research and Pathophysiology
- Social and Demographic Issues in Germany
- Alzheimer's disease research and treatments
- Aging and Gerontology Research
- Intensive Care Unit Cognitive Disorders
- Intergenerational Family Dynamics and Caregiving
- Neonatal Health and Biochemistry
- Health, psychology, and well-being
- Nutritional Studies and Diet
- Global Health Care Issues
- Metabolomics and Mass Spectrometry Studies
- Blood Pressure and Hypertension Studies
- Biochemical and Molecular Research
- Mitochondrial Function and Pathology
Technical University of Munich
2016-2025
Klinikum rechts der Isar
2015-2025
Klinik und Poliklinik für Psychiatrie und Psychotherapie
2010-2022
München Klinik
2007-2022
University Hospital Bonn
2021
University of Mannheim
2018
Sorbonne Paris Cité
2018
Inserm
2018
Centre de Recherche en Économie et Statistique
2018
Central Institute of Mental Health
1984-2016
Context: Subjective memory impairment (SMI) is receiving increasing attention as a pre-mild cognitive (MCI) condition in the course of clinical manifestation Alzheimer disease (AD).Objectives: To determine risk for conversion to any dementia, dementia AD, or vascular by SMI, graded level SMI-related worry and temporal association SMI subsequent MCI.Design: Longitudinal cohort study with follow-up examinations at 1 ⁄2 3 years after baseline.Setting: Primary care medical record registry...
To compare the risk of developing Alzheimer's disease (AD) dementia in late mild cognitive impairment (LMCI), early MCI (EMCI), and subjective memory (SMI) with normal test performance.The baseline sample (n = 2892) prospective cohort study nondemented individuals (German Study on Aging, Cognition Dementia Primary Care Patients) was divided into LMCI, EMCI, SMI, control subjects by delayed recall performance. These groups were subdivided presence self-reported concerns associated experienced...
Summary Phenylketonuria is a not uncommon cause of mental deficiency (there are probably 1600 cases in Great Britain alone). On the supposition that high level phenylalanine or its breakdown products blood and cerebrospinal fluid might be responsible for retardation this disorder we have treated two year‐old child with diet low phenylalanine. The introduction was associated an appreciable improvement patient's status fall urine. When again given fairly large amounts there immediate dramatic...
With increasing life expectancy the number of people affected by multimorbidity rises. Knowledge factors associated with health-related quality in multimorbid is scarce. We aimed to identify that are self-rated health (SRH) aged primary care patients. Cross-sectional study 3,189 patients from 65 85 years recruited 158 general practices 8 centers Germany. Information about morbidity, risk factors, resources, functional status and socio-economic data were collected face-to-face interviews....
<i>Background/Aims:</i> The aim of the study was to investigate association postoperative delirium with outcomes cognitive impairment, functional disability and death. <i>Methods:</i> Hip surgery patients aged 60 years or over (n = 200) underwent preoperative daily assessment their status during hospital stay. Outcome variables were determined at an average 8 38 months after discharge from hospital. <i>Results:</i> Fourty-one developed delirium. Delirium a...
Abstract Objective To determine incidence and risk factors for the development of postoperative acute confusional state (ACS) in elderly. Design A prospective cohort study. Setting University hospital. Patients One hundred five consecutive patients without ACS at baseline who underwent hip surgery because fracture or elective replacement. All were 60 years older. Measurements preoperative daily evaluation by a research psychiatrist. Standardized instruments used cognitive screening,...
<i>Background:</i> Although mild cognitive impairment (MCI) represents a high-risk factor for developing dementia, little is known about the prevalence of MCI among patients general practitioners (GPs). <i>Aims:</i> Estimation age-specific original and modified concepts their association with sociodemographic, medical genetic (apoE &#917;4 genotype) factors GPs. <i>Methods:</i> A GP practice sample 3,327 individuals aged 75+ was assessed by structured...
Synopsis To ascertain the frequency and distribution of new cases dementing illness in elderly population Mannheim (population 308000), a survey sample community residents > 65 years age was re-examined after an interval 7–8 years, persons long-stay care 5–6 years. The estimated annual incidence rate for all forms dementia, correction ageing samples, 15·4 per 1000 aged 65, made up dementia Alzheimer type (8·9 1000), vascular (4·4 1000) other (2·1 1000). Apart from expected association...
ABSTRACT An experiment with 25 dairy cows was performed to investigate the effects of different energy intakes on food intake, performance and blood hormone metabolite levels during last 70 days pregnancy first 125 after parturition. Compared animals fed ad libitum before parturition, only according requirements same time showed no decrease intake at calving. Cows a restricted level also faster increase in smaller deficiency onset lactation weight loss Peak milk yield lower, but peak...
Forty-seven patients at the Hospital for Sick Children, London, who had phenylketonuria and were on a low-phenylalanine diet (21 early-treated--that is, treatment started before age of 4 months--and 26 late-treated) placed normal between ages 5 15 years. They showed significant falls in mean IQ about six points after was withdrawn. Twenty-two similar (five early-treated 17 Universitäts-Kinderklinik, Heidelberg, relaxed rather than diet, smaller non-significant IQ. During period strict none...
To investigate time-dependent predictors of institutionalization in old age using a longitudinal approach.In representative survey the German general population aged 75 years and older were observed every 1.5 over six waves. Conditional fixed-effects logistic regressions (with 201 individuals 960 observations) performed to estimate effects marital status, depression, dementia, physical impairments (mobility, hearing visual impairments) on risk admission old-age home or nursing home. By...
Our objectives were (1) to test the association between report of subjective cognitive decline (SCD) and prospective objective performance in high age individuals (2) study course longitudinal before after first SCD.Cognitively normal elderly participants German Study on Ageing, Cognition, Dementia (N = 2330) with SCD (subjective memory without associated concerns) at baseline assessed over 8 years regard immediate delayed verbal recall, fluency, working memory, global cognition. Baseline...
Abstract Background The association of subjective memory impairment (SMI) with cognitive performance in healthy elderly subjects is poor because confounds such as depression. However, SMI also a predictor for future dementia. Thus, there need to identify subtypes that are particularly related inferior and may represent at-risk stages decline. Method A total 2389 unimpaired were recruited from the German Study on Ageing, Cognition Dementia Primary Care Patients (AgeCoDe), part Competence...
Background Multimorbidity has a negative impact on health-related quality of life (HRQL). Previous studies included only limited number conditions. In this study, we analyse the large conditions HRQL in multimorbid patients without preselecting particular diseases. We also explore effects these specific dimensions HRQL. Materials and Methods This analysis is based multicenter, prospective cohort study 3189 primary care aged 65 to 85. The 45 was analysed. severity rated. EQ-5D, consisting 5...
Background Current approaches for AD prediction are based on biomarkers, which however of restricted availability in primary care. tools care therefore needed. We present a score information that can be obtained the setting. Methodology/Principal Findings performed longitudinal cohort study 3.055 non-demented individuals above 75 years recruited via chart registries (Study Aging, Cognition and Dementia, AgeCoDe). After baseline investigation we three follow-up investigations at 18 months...
Leicht H, Heinrich S, Heider D, Bachmann C, Bickel van den Bussche Fuchs A, Luppa M, Maier W, Mösch E, Pentzek Rieder-Heller SG, Tebarth F, Werle J, Weyerer Wiese B, Zimmermann T, König H-H, for the AgeCoDe study group. Net costs of dementia by disease stage. Objective: To estimate net degree severity from a societal perspective, including detailed assessment formal and informal nursing care. Method: In cross-sectional study, illness were analysed in 176 patients 173 matched non-demented...
Aims. Little is known about how behavioural and psychological symptoms of dementia (BPSD) manifest in the general hospital. The aim was to examine frequency BPSD hospitals their associations with nursing staff distress complications care. Methods. Cross-sectional representative study 1469 patients aged ≥65, including 270 dementia, 33 randomly selected Germany. were reported by nurses. Results. Overall higher (76%) than without (38%). most frequent nighttime disturbances (38%), depression...
Objective The objective of this study was to describe and analyze the effects depression on health care utilization costs in a sample multimorbid elderly patients. Method This cross-sectional analysis used data prospective cohort study, consisting 1,050 randomly selected primary patients aged 65 85 years. Depression defined as score six points or more Geriatric Scale (GDS-15). Subjects passed geriatric assessment, including questionnaire for utilization. impact analyzed using multiple linear...
The care of elderly patients with comorbid dementia poses an increasing challenge in the acute inpatient setting, yet there remains a lack representative studies on prevalence and distribution general hospitals.