A5103197081- Synthesis and Reactivity of Heterocycles
- Synthesis and Reactions of Organic Compounds
- Fluorine in Organic Chemistry
- Chemical Reaction Mechanisms
- Synthesis and Characterization of Pyrroles
- Asymmetric Synthesis and Catalysis
- Synthesis of heterocyclic compounds
- Health and Medical Studies
- Synthesis of Organic Compounds
- Synthesis and Biological Evaluation
- Porphyrin and Phthalocyanine Chemistry
- Chemical Reactions and Mechanisms
- Psychosomatic Disorders and Their Treatments
- Dementia and Cognitive Impairment Research
- Liver Disease Diagnosis and Treatment
- Chemical Synthesis and Analysis
- Mental Health and Psychiatry
- Organic Chemistry Cycloaddition Reactions
- Chronic Disease Management Strategies
- Lipoproteins and Cardiovascular Health
- Selenium in Biological Systems
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Liver Disease and Transplantation
- Metal complexes synthesis and properties
Eppendorf (Germany)
2025
University Medical Center Hamburg-Eppendorf
2014-2024
Friedrich-Alexander-Universität Erlangen-Nürnberg
2006-2024
Universität Hamburg
2014-2024
Boehringer Ingelheim (Taiwan)
2024
Bielefeld University
2016-2022
Universität der Bundeswehr München
2021
Ludwig-Maximilians-Universität München
2006-2021
Roche Pharma AG (Germany)
2021
Helmholtz Zentrum München
2021
Context: Subjective memory impairment (SMI) is receiving increasing attention as a pre-mild cognitive (MCI) condition in the course of clinical manifestation Alzheimer disease (AD).Objectives: To determine risk for conversion to any dementia, dementia AD, or vascular by SMI, graded level SMI-related worry and temporal association SMI subsequent MCI.Design: Longitudinal cohort study with follow-up examinations at 1 ⁄2 3 years after baseline.Setting: Primary care medical record registry...
Sepsis is associated with an increase in reactive oxygen species and low endogenous antioxidative capacity. We postulated that high-dose supplementation of sodium-selenite would improve the outcome patients severe sepsis septic shock.Prospective randomized, placebo-controlled, multiple-center trial.Eleven intensive care units Germany.Patients were 249 systemic inflammatory response syndrome, sepsis, shock Acute Physiology Chronic Health Evaluation (APACHE) III score >70.Patients received...
Binding activity for nuclear factor kappa B (NFkappaB) consensus probes was studied in extracts from peripheral blood mononuclear cells of 15 septic patients (10 surviving and 5 not surviving). Nonsurvivors could be distinguished survivors by an increase NFkappaB binding during the observation period (P < 0.001). The comparable to APACHE-II score as a predictor outcome. Intravenous somatic gene transfer with expression plasmid coding IkappaBalpha used investigate role members family mouse...
Orange II azoreductase [NAD(P)H: 1‐(4′‐sulfophenylazo)‐2‐naphthol oxidoreductase], an enzyme catalyzing the reductive cleavage of azo bridge and related dyes, was purified to electrophoretic homogeneity from Pseudomonas species, strain KF46. This organism utilized carboxy‐Orange [1‐(4′‐carboxyphenylazo)‐2‐naphthol] but not as sole source carbon, energy, nitrogen. induced 80‐fold by both II. With two successive runs affinity chromatography using chromatographic media with different triazinyl...
Unlike in women, where instruments are available to measure the severity of symptoms, standardized lacking for aging males. However, a new 'aging males' symptoms' (AMS) rating scale has been developed present study, as well reference values.A total 116 medically well-characterized males (aged over 40 years) were recruited complete questionnaire prevalence which commonly changes with increasing age. Factor analysis was used establish raw and identify dimensions scale. This applied large...
Abstract Epidemiologic studies have indicated that high intake of saturated fat and/or animal increases the risk colon and breast cancer. Omega‐3 PUFAs in fish oil (FO) can inhibit growth human cancer cells vitro vivo . These effects are related to uptake eicosapentaenoic acid (EPA) docosahexaenoic (DHA) into cellular substrate pool their competitive metabolism with arachidonic (AA) at cyclooxygenase 5‐lipoxygenase levels. The metabolites EPA DHA less inflammatory immunosuppressant potency...
Abstract Background The association of subjective memory impairment (SMI) with cognitive performance in healthy elderly subjects is poor because confounds such as depression. However, SMI also a predictor for future dementia. Thus, there need to identify subtypes that are particularly related inferior and may represent at-risk stages decline. Method A total 2389 unimpaired were recruited from the German Study on Ageing, Cognition Dementia Primary Care Patients (AgeCoDe), part Competence...
Leicht H, Heinrich S, Heider D, Bachmann C, Bickel van den Bussche Fuchs A, Luppa M, Maier W, Mösch E, Pentzek Rieder-Heller SG, Tebarth F, Werle J, Weyerer Wiese B, Zimmermann T, König H-H, for the AgeCoDe study group. Net costs of dementia by disease stage. Objective: To estimate net degree severity from a societal perspective, including detailed assessment formal and informal nursing care. Method: In cross-sectional study, illness were analysed in 176 patients 173 matched non-demented...
To reduce culture artifacts by conventional repeated passaging and long-term in vitro, the isolation of synovial fibroblasts (SFB) was attempted from rheumatoid arthritis (RA) membranes trypsin/collagenase digest, short-term vitro adherence (7 days), negative using magnetobead-coupled anti-CD14 monoclonal antibodies. This method yielded highly enriched SFB (85% prolyl-4-hydroxylase+/74% Thy-1/CD90+ cells; <2% contaminating macrophages; <1% leukocytes/endothelial cells) that, comparison with...
Collaborative, nurse-led care is a well-established model of ambulatory in many healthcare systems. Nurses play key role managing patients' conditions as well enhancing symptom- and self-management skills. The SMADS trial evaluated the effectiveness primary care-based, nurse-led, complex intervention to promote patients with anxiety, depressive or somatic symptoms. Change self-efficacy 12 months post baseline was used outcome. set up two-arm, cluster randomised controlled city Hamburg, large...
Collaborative and stepped care (CSC) models are recommended in guidelines because of their documented effectiveness treating depression anxiety disorders. The evidence for efficacy against other mental disorders is limited. In this study, we evaluated the a collaborative model (COMET) patients with depressive, anxiety, somatoform and/or alcohol-related related comorbidities outpatient setting Germany. We conducted prospective, cluster-randomized, controlled, parallel-group superiority trial;...
Importance Collaborative care is a multicomponent intervention for patients with chronic disease in primary care. Previous meta-analyses have proven the effectiveness of collaborative depression; however, individual participant data (IPD) are needed to identify which components principal drivers this effect. Objective To assess biggest its reducing symptoms depression Data Sources were obtained from MEDLINE, Embase, Cochrane Library, PubMed, and PsycInfo as well references relevant...
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Social support has been suggested to positively influence cognition and mortality in old age. However, this suggestion questioned due inconsistent operationalisations of social among studies the small number longitudinal available. This study aims investigate perceived support, understood as emotional component on age part a prospective multicentre Germany. A national subsample 2,367 primary care patients was assessed twice over an observation period 18 months regarding cognitive function...