A5027047016- Pharmaceutical Practices and Patient Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Health Policy Implementation Science
- Primary Care and Health Outcomes
- Pharmaceutical studies and practices
- Pharmacovigilance and Adverse Drug Reactions
- Mental Health Treatment and Access
- COVID-19 and Mental Health
- Clinical practice guidelines implementation
- Vaccine Coverage and Hesitancy
- Schizophrenia research and treatment
- Acute Kidney Injury Research
- Chronic Disease Management Strategies
- Inflammatory mediators and NSAID effects
- Patient Safety and Medication Errors
- Medication Adherence and Compliance
- Pharmaceutical Economics and Policy
- Gastroesophageal reflux and treatments
- Child and Adolescent Psychosocial and Emotional Development
- Poisoning and overdose treatments
- Healthcare Quality and Management
- Cardiac Health and Mental Health
- Microscopic Colitis
- Medical Imaging and Pathology Studies
- Digital Mental Health Interventions
Ludwig-Maximilians-Universität München
2019-2025
LMU Klinikum
2020-2025
German Center for Pediatric and Adolescent Rheumatology
2025
Johns Hopkins University
2024
University Hospital Heidelberg
2022
Witten/Herdecke University
2022
Heidelberg University
2022
Friedrich Schiller University Jena
2021
München Klinik
2020-2021
University of Dundee
2012-2020
The escalating use of prescribed drugs has increasingly raised concerns about polypharmacy. This study aims to examine changes in rates polypharmacy and potentially serious drug-drug interactions a stable geographical population between 1995 2010. is repeated cross-sectional analysis community-dispensed prescribing data for all 310,000 adults resident the Tayside region Scotland number drug classes dispensed (DDIs) previous 84 days were calculated, age-sex standardised 2010 compared. Patient...
Process evaluations are recommended to open the ‘black box’ of complex interventions evaluated in trials, but there is limited guidance help researchers design process evaluations. Much current literature on focuses qualitative methods, with less attention paid quantitative methods. This discrepancy led us develop our own framework for designing cluster-randomised controlled trials. We reviewed recent theoretical and methodological selected published evaluations; these publications...
Many definitions of the term clinical pharmacy exist, but a number ambiguities remain. In order to clarify European Society Clinical Pharmacy (ESCP) position on what defines pharmacy, consultation exercise was conducted among ESCP members with findings used as basis for an updated definition. The definition clarifies that (1) represents both professional practice and field research, (2) aims optimise utilisation medicines in achieve person-centered public health goals, (3) encompasses...
To examine the prevalence and patterns of high risk prescribing, defined as potentially inappropriate prescribing drugs to primary care patients particularly vulnerable adverse drug events.Cross sectional population database analysis.General practices in Scotland.315 Scottish general with 1.76 million registered patients, 139 404 (7.9%) whom were events because age, comorbidity, or co-prescription.How reliably each 15 indicators-four for non-steroidal anti-inflammatory drugs, co-prescription...
High-risk prescribing and preventable drug-related complications are common in primary care. We evaluated whether the rates of high-risk by care clinicians related clinical outcomes would be reduced a complex intervention.In this cluster-randomized, stepped-wedge trial conducted Tayside, Scotland, we randomly assigned participating practices to various start dates for 48-week intervention comprising professional education, informatics facilitate review, financial incentives review patients'...
Addressing the problem of preventable drug related morbidity (PDRM) in primary care is a challenge for health systems internationally. The increasing implementation clinical information UK and internationally provide new opportunities to systematically identify patients at risk PDRM targeted medication review. objectives this study were (1) develop set explicit assessment criteria with sub-optimally effective or high-risk use from electronic medical records (2) topics that are perceived by...
Despite general practitioners' (GPs') key role in Germany`s primary health care, clinical research practice is scarce. Clinical mainly conducted at inpatient facilities, although their results are rarely transferable. German GPs have no extra time or funding for research, as well limited training. To support practice-based networks (PBRNs) developed. As they will be based on an active involvement of GPs, we need more information GPs` participation-readiness. The aim this study was to explore...
Abstract Background Antidepressants are first-line medications for many psychiatric disorders. However, their widespread long-term use in some indications (e.g., mild depression and insomnia) is concerning. Particularly older adults with comorbidities polypharmacy, who more susceptible to adverse drug reactions, the risks benefits of treatment should be regularly reviewed. The aim this consensus process was identify explicit criteria potentially inappropriate antidepressant (indicators)...
General practitioners play an important role in the first-line care of individuals with mental health conditions. However, factors such as time constraints, limited experience managing conditions and high rates comorbidity may hinder adequate treatment. To improve psychological care, adopting a transdiagnostic approach shows potential. Research on interventions delivered by general is scarce. Thus, intervention adapted from Unified Protocol for Transdiagnostic Treatment Emotional Disorders...
Abstract Background Practice-based research networks (PBRNs) have been implemented to support clinical in German general practice since 2020. General practitioners (GPs) are often critical concerning the feasibility of trials. Among others, high workload, lack resources GP teams and little acceptance trial requirements by patients assumed barriers. Therefore, aim this study was evaluate perspectives their on set up BayFoNet during implementation two pilot cluster-randomized trials improve...
Abstract We present a cross-sectional analysis of 1391 outpatients and 280 inpatients participating in subprojects the Research Training Group POKAL, whom 1609 had PHQ-9 score ≥ 5 62 reported depression with antidepressant use. Antidepressant use was lower among than (28.5% vs. 82.5%), higher levels SSRI monotherapy (44.1% 25.5%). Of users, 80.1% potentially inadequate treatment response, 21.7% high-risk those severe symptoms, 42.1% were undertreated. Key risk factors anxiety (for response)...
Adverse drug reactions (ADRs) are a common cause of morbidity and mortality in hospitalized patients. Identification ADRs clinical practice, surveillance research is essential to prevent further harm. The aim this study was assess the likelihood drugs contributing clinically important inpatient adverse events, order provide list drug‐event pairs indicating electronic health record (EHR) data, referred as “indicators ADRs”. We conducted consensus process based on RAND/UCLA Appropriateness...
Importance Collaborative care is a multicomponent intervention for patients with chronic disease in primary care. Previous meta-analyses have proven the effectiveness of collaborative depression; however, individual participant data (IPD) are needed to identify which components principal drivers this effect. Objective To assess biggest its reducing symptoms depression Data Sources were obtained from MEDLINE, Embase, Cochrane Library, PubMed, and PsycInfo as well references relevant...
Zusammenfassung Hintergrund Patienten mit Suizidabsicht suchen vor dem Suizid oft ihren Hausarzt auf. Hausärzte können Schwierigkeiten haben, Suizidalität anzusprechen und Warnsignale zu erkennen. Diese qualitative Studie untersucht die Erfahrungen von Hausärzten im Umgang suizidalen Patienten, um Herausforderungen erleichternde Faktoren identifizieren. Methodik Befragung 21 mittels semistrukturierten Interviews, transkribiert qualitativ nach Kuckartz analysiert wurden. Ergebnisse bemühen...
Abstract Background Advances in critical care medicine have led to a growing number of illness survivors. A considerable part them suffers from long-term sequelae, also known as post-intensive syndrome. Among these, depressive symptoms are frequently observed. Depressive symptom trajectories and associated factors survivors rarely been investigated. Study objective was explore compare different sepsis over 1 year after discharge ICU. Methods Data randomized controlled trial on post-sepsis...
High-risk prescribing of non-steroidal anti-inflammatory drugs (NSAIDs) and antiplatelet agents accounts for a significant proportion hospital admissions due to preventable adverse drug events. The recently completed PINCER trial has demonstrated that one-off pharmacist-led information technology (IT)-based intervention can significantly reduce high-risk in primary care, but there is evidence effects decrease over time employing additional pharmacists facilitate change may not be...
Introduction General practitioners often criticise clinical trials for their poor applicability in primary care, which may at least partially explain why engagement care research remains limited. In order to enhance research, the German government has funded six regional practice based networks (PBRNs). Within Bavarian PBRN (BayFoNet), two cluster-randomised pilot will be conducted. This paper presents protocol of process evaluation accompanying both trials, aims explore relevance,...
Vaccinations against COVID-19 are of the utmost importance in long-term care facilities. During pandemic, mental health issues increased significantly. This cross-sectional analysis aimed to assess associations depression and anxiety with literacy people need association burnout vaccination readiness workers (HCWs). Within our study, were assessed for symptoms (PHQ-9), (GAD-7), (HLS-EU-Q16). Among HCWs, we (PHQ-9) (MBI-HSS), as well psychological antecedents (5C) measure COVID-19. A...