A5021936961- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Amyotrophic Lateral Sclerosis Research
- Alzheimer's disease research and treatments
- Parkinson's Disease Mechanisms and Treatments
- Metabolism and Genetic Disorders
- Neurogenetic and Muscular Disorders Research
- Polyomavirus and related diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- S100 Proteins and Annexins
- Systemic Lupus Erythematosus Research
- Bacterial Infections and Vaccines
- Immunotherapy and Immune Responses
- Prion Diseases and Protein Misfolding
- Cerebrospinal fluid and hydrocephalus
- Rheumatoid Arthritis Research and Therapies
- Neurological diseases and metabolism
- Genetic Neurodegenerative Diseases
- Cytokine Signaling Pathways and Interactions
- Hereditary Neurological Disorders
- Autoimmune Neurological Disorders and Treatments
- RNA regulation and disease
- Tryptophan and brain disorders
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Mitochondrial Function and Pathology
Universität Ulm
2016-2025
University Hospital Ulm
2016-2025
German Center for Neurodegenerative Diseases
2023-2025
Klinik und Poliklinik für Neurologie
2009-2025
Hôpital de la Timone
2023-2024
Universität Innsbruck
2024
Landscape Research Group
2023
Authorised Association Consortium
2023
Fachklinik für Neurologie Dietenbronn
2016-2022
Nia Association
2022
Abstract Background The diagnostic and pathophysiological relevance of antibodies to aquaporin-4 (AQP4-Ab) in patients with neuromyelitis optica spectrum disorders (NMOSD) has been intensively studied. However, little is known so far about the clinical impact AQP4-Ab seropositivity. Objective To analyse systematically paraclinical features associated NMO Caucasians a stratified fashion according patients' serostatus. Methods Retrospective study 175 Caucasian (AQP4-Ab positive 78.3%). Results...
<h3>Objectives</h3> Biomarkers for the diagnosis of motoneuron diseases (MND) are urgently needed to improve diagnostic pathway, patient stratification and monitoring. The aim this study was validate candidate markers MND in cerebrospinal fluid (CSF) specify cut-offs based on large cohorts by especially considering patients who were seen under initial differential (MND mimics). <h3>Methods</h3> In a prospective study, we investigated CSF 455 neurofilament light chain (NfL), phosphorylated...
Abstract While neurofilament light chain (NfL) measurement in serum is a well-established marker of neuroaxonal damage multiple sclerosis (MS), data on astroglial markers are missing. In our study, glial fibrillary acid protein (GFAP) and NfL were measured cerebrospinal fluid (CSF) MS patients with other non-inflammatory neurological diseases (OND) using the Simoa technology. Clinical like age, gender, expanded disability status scale (EDSS) MRI findings correlated to neurochemical markers....
Significance Oligoclonal bands (OCBs) of the cerebrospinal fluid (CSF) are a hallmark multiple sclerosis (MS). They expanded antibody species that detectable in >95% patients. Because several OCB and polyclonal antibodies present CSF sample, it was for technical reasons thus far not possible to isolate distinct OCBs identify their antigens. Here we combined refined biochemical analysis, proteomics, transcriptomics molecularly characterize antibodies. We produced six recombinant...
Abstract Background Comprehensive data on the cerebrospinal fluid (CSF) profile in patients with COVID-19 and neurological involvement from large-scale multicenter studies are missing so far. Objective To analyze systematically CSF COVID-19. Methods Retrospective analysis of 150 lumbar punctures 127 PCR-proven symptoms seen at 17 European university centers Results The most frequent pathological finding was blood-CSF barrier (BCB) dysfunction (median QAlb 11.4 [6.72–50.8]), which present...
In April 2023, the antisense oligonucleotide tofersen was approved by U.S. Food and Drug Administration (FDA) for treatment of
Abstract We determined the cytokine messenger RNA (mRNA) expression pattern of blood mononuclear cells in 29 patients with relapsing‐remitting multiple sclerosis every 4 weeks over a period 12 months. During this 27 relapses occurred 14 (48%). Progression disease activity as assessed by occurrence new lesions on nonenhancing T2‐weighted magnetic resonance images head was detected (48%) 25 patients. Using semiquantitative polymerase chain reaction we demonstrated significant increases tumor...
To test whether biomarkers for axonal degeneration correlated with clinical subtypes and were of use in predicting progression ALS.Patients ALS (n = 69), patients Alzheimer disease (AD; n 73), age-matched controls 33) included this prospective study. CSF levels tau protein neurofilaments (NfHSMI35) measured using ELISA. In 49 ALS, follow-up data available (median 7 months).CSF NfHSMI35 five times higher (1.7 ng/mL) than (0.3 ng/mL, p < 0.001) 10 AD (0.14 0.001). values also upper motor...
We determined the cytokine messenger RNA (mRNA) expression pattern of blood mononuclear cells in 45 patients with relapsing-remitting form MS and 32 other neurologic diseases. Using a semiquantitative polymerase chain reaction method, we detected significantly higher levels tumor necrosis factor-alpha lymphotoxin mRNA relapsing compared to those stable disease (<i>p</i> < 0.001), but transforming growth factor-beta interleukin-10 expressions were disease.
Background: Recently, TAR DNA-binding protein 43 (TDP-43) was identified as the major component of ubiquitin-positive tau-negative neuronal and glial inclusions in most common form frontotemporal lobar degeneration (FTLD) amyotrophic lateral sclerosis (ALS).It demonstrated that different TDP-43 profiles correspond to clinical phenotypes FTLD or ALS subgroups, differential diagnostic potential suggested.Objectives: To examine cerebrospinal fluid (CSF) analyze whether it could serve a...
Chitinase 3-like 1 (CHI3L1) has been proposed as a biomarker associated with the conversion to clinically definite multiple sclerosis in patients isolated syndromes, based on finding of increased cerebrospinal fluid CHI3L1 levels syndrome who later converted compared those remained syndrome. Here, we aimed validate prognostic large cohort This is longitudinal study clinical, magnetic resonance imaging, and data prospectively acquired. A total 813 samples from were recruited 15 European...
To analyse predictors for relapses and number of attacks under different immunotherapies in patients with neuromyelitis optica spectrum disorder (NMOSD).This is a retrospective cohort study conducted neurology departments at 21 regional university hospitals Germany. Eligible participants were aquaporin-4-antibody-positive or aquaporin-4-antibody-negative NMOSD. Main outcome measures HRs from Cox proportional hazard regression models adjusted centre effects, important prognostic factors...
Background There is increasing recognition of the importance B lymphocytes in immunopathogenesis multiple sclerosis (MS), encouraging evaluation cell-associated biomarkers cerebrospinal fluid (CSF). We aimed to evaluate relevance cell chemoattractant CXCL13 as a prognostic marker patients with clinically isolated syndrome (CIS) regarding conversion MS, and compare it Barkhof criteria magnetic resonance imaging (MRI), oligoclonal bands (OCB) polyspecific intrathecal response against measles,...
To assess outcomes for patients treated with interferon beta-1b immediately after clinically isolated syndrome (CIS) or a short delay.Participants in BENEFIT (Betaferon/Betaseron Newly Emerging MS Initial Treatment) were randomly assigned to receive (early treatment) placebo (delayed treatment). After conversion definite multiple sclerosis (CDMS) 2 years, on could switch another treatment. Eleven years randomization, reassessed.Two hundred seventy-eight (59.4%) of the original 468 (71.3%...