A5064362900- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Optical Imaging and Spectroscopy Techniques
- Acute Ischemic Stroke Management
- Cerebrospinal fluid and hydrocephalus
- Intracerebral and Subarachnoid Hemorrhage Research
- Long-Term Effects of COVID-19
- Artificial Intelligence in Healthcare and Education
- Bacterial Infections and Vaccines
- Respiratory Support and Mechanisms
- Traumatic Brain Injury Research
- Neurosurgical Procedures and Complications
- COVID-19 Clinical Research Studies
- Explainable Artificial Intelligence (XAI)
- Functional Brain Connectivity Studies
- Cerebrovascular and Carotid Artery Diseases
- Hemoglobin structure and function
- Cardiac Arrest and Resuscitation
- Healthcare Technology and Patient Monitoring
- Machine Learning in Healthcare
- EEG and Brain-Computer Interfaces
- Thermal Regulation in Medicine
- Electronic Health Records Systems
- Microfluidic and Bio-sensing Technologies
- Non-Invasive Vital Sign Monitoring
University Hospital of Zurich
2016-2024
University of Zurich
2016-2024
Institute of Materials, Minerals and Mining
2024
ETH Zurich
2022
FHNW University of Applied Sciences and Arts
2022
Weatherford College
2022
Abstract Background Comprehensive data on the cerebrospinal fluid (CSF) profile in patients with COVID-19 and neurological involvement from large-scale multicenter studies are missing so far. Objective To analyze systematically CSF COVID-19. Methods Retrospective analysis of 150 lumbar punctures 127 PCR-proven symptoms seen at 17 European university centers Results The most frequent pathological finding was blood-CSF barrier (BCB) dysfunction (median QAlb 11.4 [6.72–50.8]), which present...
Explainable artificial intelligence (XAI) has emerged as a promising solution for addressing the implementation challenges of AI/ML in healthcare. However, little is known about how developers and clinicians interpret XAI what conflicting goals requirements they may have. This paper presents findings longitudinal multi-method study involving 112 co-designing an clinical decision support system. Our identifies three key differences between developer clinician mental models XAI, including...
Background and Purpose: Case series indicating cerebrovascular disorders in coronavirus disease 2019 (COVID-19) have been published. Comprehensive workups, including clinical characteristics, laboratory, electroencephalography, neuroimaging, cerebrospinal fluid findings, are needed to understand the mechanisms. Methods: We evaluated 32 consecutive critically ill patients with COVID-19 treated at a tertiary care center from March 9 April 3, 2020, for concomitant severe central nervous system...
Secondary brain injury after aneurysmal subarachnoid hemorrhage (SAH-SBI) contributes to poor outcomes in patients rupture of an intracranial aneurysm. The lack diagnostic biomarkers and novel drug targets represent unmet need. aim this study was investigate the clinical pathophysiological association between cerebrospinal fluid hemoglobin (CSF-Hb) SAH-SBI. In a cohort 47 patients, we collected daily CSF-samples within 14 days aneurysm rupture. There very strong evidence for positive...
ICU Cockpit: a secure, fast, and scalable platform for collecting multimodal waveform data, online historical data visualization, validation of algorithms in the intensive care unit. We present network software services that continuously stream waveforms from beds to databases web-based user interface. Machine learning process streams send outputs The architecture capabilities are described. Since 2016, has processed over 89 billion points (N = 979 patients) 200 signals (0.5-500 Hz)...
OBJECTIVE In neurocritical care, data from multiple biosensors are continuously measured, but only sporadically acknowledged by the attending physicians. contrast, machine learning (ML) tools can analyze large amounts of continuously, taking advantage underlying information. However, performance such ML-based solutions is limited different factors, for example, patient motion, manipulation, or, as in case external ventricular drains (EVDs), drainage CSF to control intracranial pressure...
Detection of delayed cerebral ischemia (DCI) is challenging in comatose patients with poor-grade aneurysmal subarachnoid hemorrhage (aSAH). Brain tissue oxygen pressure (PbtO2) monitoring may allow early detection its occurrence. Recently, a probe for combined measurement intracranial (ICP) and intraparenchymal near-infrared spectroscopy (NIRS) has become available. In this pilot study, the parameters PbtO2, Hboxy, Hbdeoxy, Hbtotal rSO2 were measured parallel evaluated their potential to...
Signal complexity (i.e. entropy) describes the level of order within a system. Low physiological signal predicts unfavorable outcome in variety diseases and is assumed to reflect increased rigidity cardio/cerebrovascular system leading (or reflecting) autoregulation failure. Aneurysmal subarachnoid hemorrhage (aSAH) followed by cascade complex systemic cerebral sequelae. In aSAH, value entropy has not been established yet.
Recognition of typical patterns brain response to external stimuli using near-infrared spectroscopy (fNIRS) may become a gateway detecting covert consciousness in clinically unresponsive patients. This is the first fNIRS study on cortical hemodynamic favorite music frequency domain approach. The aim this was identify possible marker cognitive healthy subjects by investigating variations oscillatory signal spectral regions low-frequency (LFO) and very-low-frequency oscillations (VLFO)....
Flow diversion treatment of ruptured cerebral aneurysms remains challenging due to the need for double-antiplatelet therapy. We report our experience with flow-diverter stent (FDS) reconstruction single-antiplatelet therapy blood blister and dissecting aneurysms.In this case series we performed a retrospective analysis all patients who were treated phosphoryl-bonded FDS between 2019 2022 in single center. Periprocedurally, received weight-adapted eptifibatide IV heparin IV. After 6-24 hours,...
BACKGROUND: Intracranial pressure (ICP) and arterial blood (ABP) are related to each other through cerebral autoregulation. Central venous (CVP) is often measured estimate cardiac filling pressures as an approximate measure for the volume status of a patient. Prior modelling efforts have formalized functional relationship between CVP, ICP ABP. However, these models were used explain short segments data during controlled experiments not yet been slowly evolving increase that occurs typically...
Delayed cerebral ischemia (DCI) occurs in up to one third of patients suffering from aneurysmal subarachnoid hemorrhage (aSAH). Untreated, it leads secondary infarctions and is frequently associated with death or severe disability. After aneurysm rupture, erythrocytes the space lyse liberate free hemoglobin (Hb), a key driver for development DCI. Hemoglobin cerebrospinal fluid (CSF-Hb) can be analyzed through two-step procedure centrifugation exclude intact subsequent spectrophotometric...
Abstract Spectrum power analysis in the low frequency oscillations (LFO) region of functional near infrared spectroscopy (fNIRS) is a promising method to deliver information about brain activation and therefore might be used for prognostication patients with disorders consciousness neurocritical care unit alongside established methods. In this study, we measure cortical hemodynamic response measured by fNIRS LFO following auditory somatosensory stimulation healthy subjects. The significant...
Background: Accurate longitudinal risk prediction for DCI (delayed cerebral ischemia) occurrence after subarachnoid hemorrhage (SAH) is essential clinicians to administer appropriate and timely diagnostics, thereby improving treatment planning outcome. This study aimed develop an improved model evaluate its performance in predicting between day 4 14 aneurysm rupture. Methods: Two classification models were trained: (1) a static based on routinely collected demographics SAH grading scores (2)...
OBJECTIVE The reason for a rebleed after an initial hemorrhage in patients with aneurysmal subarachnoid (aSAH) is considered multifactorial. Antiplatelet use one of the factors that has been related to early and worse outcome aSAH. Thrombocyte transfusion overcomes inhibitory effects antiplatelet agents by increasing number functional thrombocytes, but its impact on rate clinical remains unknown. aim this study was assess effect thrombocyte rebleeding aSAH prehemorrhage use, considering...
Abstract Secondary brain injury after aneurysmal subarachnoid hemorrhage (SAH-SBI) is a significant contributor to poor outcomes in patients rupture of an intracranial aneurysm. The lack diagnostic biomarkers and novel drug targets represent unmet need. Prior experimental evidence has suggested cell-free hemoglobin the cerebrospinal fluid (CSF-Hb) as pathophysiological driver SAH-SBI. aim this study was investigate clinical association between CSF-Hb We prospectively enrolled 47 consecutive...
Data on critically ill patients with spontaneous empyema or brain abscess are limited. The aim was to evaluate clinical presentations, factors, and microbiological findings associated the outcome in treated a Neurocritical Care Unit.In this retrospective study, we analyzed 45 out of 101 screened epidural subdural and/or at tertiary care center between January 2012 December 2019. Patients postoperative infections spinal were excluded. Medical records reviewed for baseline characteristics,...
Abstract Background Nimodipine is routinely administered in patients with aneurysmal subarachnoid hemorrhage (aSAH). However, the effect of nimodipine on oxygen exchange lungs insufficiently explored. Methods The study explored medication artificially ventilated aSAH. data collection period was divided into nimodipine-dependent (ND) and nimodipine-independent (NID) periods. Values for arterial partial pressure (PaO 2 ) fraction inspired (FiO were collected compared between Patients those...
Abstract Background Blood pressure variability (BPV) is associated with outcome after endovascular thrombectomy in acute large vessel occlusion stroke. We aimed to provide the optimal sampling frequency and BPV index for prediction by using high-resolution blood (BP) data. Methods Patient characteristics, 3-month outcome, BP values measured intraarterially at 1 Hz up 24 h were extracted from 34 patients treated a tertiary care center neurocritical unit. Outcome was dichotomized (modified...
Abstract Explainable AI (XAI) is considered the number one solution for overcoming implementation hurdles of AI/ML in clinical practice. However, it still unclear how clinicians and developers interpret XAI (differently) whether building such systems achievable or even desirable. This longitudinal multi-method study queries (n=112) as they co-developed DCIP – an ML-based prediction system Delayed Cerebral Ischemia. The resulting framework reveals that ambidexterity between exploration...