A5052637254- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Cerebrospinal fluid and hydrocephalus
- Intracerebral and Subarachnoid Hemorrhage Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Neurosurgical Procedures and Complications
- Hemoglobin structure and function
- Plant and animal studies
- Insect and Arachnid Ecology and Behavior
- Insect and Pesticide Research
- Medical Image Segmentation Techniques
- Advanced Radiotherapy Techniques
- Cell Image Analysis Techniques
- MRI in cancer diagnosis
- Pancreatic and Hepatic Oncology Research
- Optical Imaging and Spectroscopy Techniques
- Ultrasound Imaging and Elastography
- AI in cancer detection
- Nuclear Physics and Applications
- Surgical Simulation and Training
- Advanced Neural Network Applications
- Immune cells in cancer
- Acute Ischemic Stroke Management
- Animal testing and alternatives
- Advanced X-ray Imaging Techniques
University of Zurich
2021-2024
University Hospital of Zurich
2021-2024
The Netherlands Cancer Institute
2020-2023
Oncode Institute
2020
Massachusetts General Hospital
2019
Secondary brain injury after aneurysmal subarachnoid hemorrhage (SAH-SBI) contributes to poor outcomes in patients rupture of an intracranial aneurysm. The lack diagnostic biomarkers and novel drug targets represent unmet need. aim this study was investigate the clinical pathophysiological association between cerebrospinal fluid hemoglobin (CSF-Hb) SAH-SBI. In a cohort 47 patients, we collected daily CSF-samples within 14 days aneurysm rupture. There very strong evidence for positive...
Secondary brain injury (SBI) occurs with a lag of several days post-bleeding in patients aneurysmal subarachnoid hemorrhage (aSAH) and is strong contributor to mortality long-term morbidity. aSAH-SBI coincides cell-free hemoglobin (Hb) release into the cerebrospinal fluid. This temporal association convincing pathophysiological concepts suggest that CSF-Hb could be targetable trigger SBI. However, sparse experimental evidence for Hb's neurotoxicity vivo defines significant research gap...
Abstract Dual-energy CT (DECT) was introduced to address the inability of conventional single-energy computed tomography (SECT) distinguish materials with similar absorbances but different elemental compositions. However, material decomposition algorithms based purely on physics underlying attenuation process have several limitations, leading low signal-to-noise ratio (SNR) in derived material-specific images. To overcome these, we trained a convolutional neural network (CNN) develop...
The functional neurological outcome of patients with intracerebral hemorrhage (ICH) strongly relates to the degree secondary brain injury (ICH-SBI) evolving within days after initial bleeding. Different mechanisms including incitement inflammatory pathways, dysfunction blood-brain barrier (BBB), activation resident microglia, and an influx blood-borne immune cells, have been hypothesized contribute ICH-SBI. Yet, spatiotemporal interplay specific processes different compartments has not...
Preclinical studies provided a strong rationale for pathophysiological link between cell-free hemoglobin in the cerebrospinal fluid (CSF-Hb) and secondary brain injury after subarachnoid hemorrhage (SAH-SBI). In single-center prospective observational clinical study, external ventricular drain (EVD) based CSF-Hb proved to be promising biomarker monitor SAH-SBI. The primary objective of HeMoVal study is prospectively validate association EVD SAH-SBI during first 14 days post-SAH. Secondary...
Cerebrospinal fluid hemoglobin has been positioned as a potential biomarker and drug target for aneurysmal subarachnoid hemorrhage-related secondary brain injury (SAH-SBI). The maximum amount of hemoglobin, which may be released into the cerebrospinal fluid, is defined by initial hematoma volume (ISHV). In patients without external ventricular or lumbar drain, there remains an unmet clinical need to predict risk SAH-SBI. aim this study was explore automated segmentation ISHV surrogate...
Registration of pre- and intraoperative images is a crucial step surgical liver navigation, where rigid registration vessel centerlines currently commonly used. When using 3D ultrasound (US), accuracy during navigation might be influenced by the size US volume, yet relationship between volume understudied. In this study, we specify an optimal for varying volumes vasculature. While previous studies measured at registered fiducials, in work, determined target lesion which clinically most...
Accurate hepatic vessel segmentation on ultrasound (US) images can be an important tool in the planning and execution of surgery, however proves to a challenging task due noise speckle. Our method comprises reduced filter 3D U-Net implementation automatically detect vasculature US volumes. A comparison is made between volumes acquired with probe stacked 2D based electromagnetic tracking. Experiments are conducted 67 scans, where 45 used training, 12 validation 10 testing. This network...
The functional outcome of patients with intracranial hemorrhage strongly relates to the degree secondary brain injury (SBI) evolving within days after initial bleeding. spatiotemporal interplay specific inflammatory processes different compartments has not been sufficiently characterized, limiting potential therapeutic interventions prevent and treat SBI.
Preclinical studies indicate that the systemic application of C1-inhibitor, clinically used to treat hereditary angioedema, reduces secondary brain injury after ischemic stroke. This study assessed effect C1-inhibitor on hemorrhagic We an established striatal whole-blood injection mouse model mimic intracerebral hemorrhage-related injury. Based spatiotemporal dynamics in our model, we calculated necessary sample size (n = 24) and determined most sensitive time point detect potential group...
Abstract Secondary brain injury after aneurysmal subarachnoid hemorrhage (SAH-SBI) is a significant contributor to poor outcomes in patients rupture of an intracranial aneurysm. The lack diagnostic biomarkers and novel drug targets represent unmet need. Prior experimental evidence has suggested cell-free hemoglobin the cerebrospinal fluid (CSF-Hb) as pathophysiological driver SAH-SBI. aim this study was investigate clinical association between CSF-Hb We prospectively enrolled 47 consecutive...
In recent years, insect husbandry has seen an increased interest in order to supply the production of raw materials, food, or as biological/environmental control. Unfortunately, large rearings are susceptible pathogens, pests and parasitoids which can spread rapidly due confined nature a rearing system. Thus, it is monitor such manifestations overall population size quickly efficiently. Medical imaging techniques could be used for this purpose, volumes scanned non-invasively. Due its 3D...
G-ratio is crucial for understanding the nervous system’s health and function as it measures relative myelin thickness around an axon. However, manual measurement biased variable, emphasizing need automated standardized technique. Although deep learning holds promise, current implementations lack clinical relevance generalizability. This study aimed to develop pipeline selecting nerve fibers calculating relevant g-ratio using quality parameters in optical microscopy. Histological sections...
<title>Abstract</title> Background Secondary brain injury (SBI) occurs with a lag of several days post-bleeding in patients aneurysmal subarachnoid hemorrhage (aSAH) and is strong contributor to mortality long-term morbidity. aSAH-SBI coincides cell-free hemoglobin (Hb) release into the cerebrospinal fluid. This temporal association convincing pathophysiological concepts suggest that CSF-Hb could be targetable trigger SBI. However, sparse experimental evidence for Hb’s neurotoxicity vivo...
<title>Abstract</title> Background Secondary brain injury (SBI) occurs with a lag of several days post-bleeding in patients aneurysmal subarachnoid hemorrhage (aSAH) and is strong contributor to mortality long-term morbidity. aSAH-SBI coincides cell-free hemoglobin (Hb) release into the cerebrospinal fluid. This temporal association convincing pathophysiological concepts suggest that CSF-Hb could be targetable trigger SBI. However, sparse experimental evidence for Hb’s neurotoxicity vivo...
<title>Abstract</title> <bold>Purpose</bold>Cell-free hemoglobin in the cerebrospinal fluid (CSF-Hb) may be one of main drivers secondary brain injury after aneurysmal subarachnoid hemorrhage (aSAH). Haptoglobin scavenging CSF-Hb has been shown to mitigate cerebrovascular disruption. Using digital subtraction angiography (DSA) and blood oxygenation-level dependent reactivity imaging (BOLD-CVR) aim was assess acute toxic effect on cerebral flow autoregulation, as well test protective effects...