A5033822563- Cerebrovascular and Carotid Artery Diseases
- Advanced MRI Techniques and Applications
- Acute Ischemic Stroke Management
- Intracranial Aneurysms: Treatment and Complications
- Advanced Neuroimaging Techniques and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Glioma Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- Functional Brain Connectivity Studies
- MRI in cancer diagnosis
- Vascular Malformations Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Cardiovascular Health and Disease Prevention
- Meningioma and schwannoma management
- Fetal and Pediatric Neurological Disorders
- Medical Imaging and Analysis
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurological Disease Mechanisms and Treatments
- Pituitary Gland Disorders and Treatments
- Moyamoya disease diagnosis and treatment
- Medical Imaging Techniques and Applications
- Spinal Dysraphism and Malformations
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Imaging and Diagnostics
- Cardiac Arrest and Resuscitation
University Hospital of Zurich
2016-2024
University of Zurich
2016-2024
Cereneo
2024
Individual Differences
2022
Weatherford College
2022
Center for Neurosciences
2022
Background and Purpose— Increased stroke risk correlates with hemodynamic failure, which can be assessed ( 15 O-)H 2 O positron emission tomography (PET) cerebral blood flow (CBF) measurements. This gold standard technique, however, is not established for routine clinical imaging. Standardized oxygen-level–dependent (BOLD) functional magnetic resonance imaging+CO a noninvasive potentially widely applicable tool to assess whole-brain quantitative cerebrovascular reactivity (CVR). We examined...
Abstract Background Recent technological advances have led to the development and implementation of machine learning (ML) in various disciplines, including neurosurgery. Our goal was conduct a comprehensive survey neurosurgeons assess acceptance attitudes toward ML neurosurgical practice identify factors associated with its use. Methods The online consisted nine or ten mandatory questions distributed February March 2019 through European Association Neurosurgical Societies (EANS) Congress...
Impaired cerebrovascular reactivity (CVR) has been correlated with recurrent ischemic stroke. However, for clinical purposes, most CVR techniques are rather complex, time-consuming, and lack validation quantitative measurements. The recent adaptation of a standardized hypercapnic stimulus in combination blood-oxygenation-level-dependent (BOLD) magnetic resonance imaging signal as surrogate cerebral blood flow offers potential universally comparable assessment. We investigated the association...
OBJECTIVE Gross-total resection (GTR) is often the primary surgical goal in transsphenoidal surgery for pituitary adenoma. Existing classifications are effective at predicting GTR but hampered by limited discriminatory ability moderate cases and poor interrater agreement. Deep learning, a subset of machine has recently established itself as highly forecasting medical outcomes. In this pilot study, authors aimed to evaluate utility using deep learning predict after METHODS Data from...
OBJECTIVE Although rates of postoperative morbidity and mortality have become relatively low in patients undergoing transnasal transsphenoidal surgery (TSS) for pituitary adenoma, cerebrospinal fluid (CSF) fistulas remain a major driver morbidity. Persistent CSF harbor the potential headache meningitis. The aim this study was to investigate whether neural network–based models can reliably identify at high risk intraoperative leakage. METHODS From prospective registry, who underwent...
Abstract Objective To improve quantitative cerebrovascular reactivity ( CVR ) measurements and CO 2 arrival times, we present an iterative analysis capable of decomposing different temporal components the dynamic carbon dioxide‐ Blood Oxygen‐Level Dependent ‐ BOLD relationship. Experimental Design Decomposition parameters included a redefinition voxel‐wise time, separation from vascular response to stepwise increase in (Delay signal Plateau – DTP decrease Baseline DTB ). Twenty‐five (normal)...
To study blood oxygen level-dependent cerebrovascular reactivity (BOLD-CVR) as a surrogate imaging marker for crossed cerebellar diaschisis (CCD).Twenty-five participants with symptomatic unilateral steno-occlusive disease underwent BOLD-CVR and an acetazolamide challenged (15O)-H2O-PET study. CCD asymmetry index were determined from PET compared to quantitative values. Neurologic status at admission outcome after 3 months NIH Stroke Scale (NIHSS) modified Rankin (mRS) scores.For both the...
Reliable preoperative identification of patients at high risk for early postoperative complications occurring within 24 h (EPC) intracranial tumor surgery can improve patient safety and management. Statistical analysis using machine learning algorithms may generate models that predict EPC better than conventional statistical methods.To train such a model to assess its predictive ability.This cohort study included from an ongoing prospective registry single tertiary care center with underwent...
Endovascular recanalization trials have shown a positive impact on the preservation of ischemic penumbra in patients with acute large vessel occlusion (LVO). The concept salvation can be extended to surgical revascularization bypass highly selected patients. For selecting these patients, authors propose flowchart based multimodal MRI.
Increased awareness around neurocognitive deficits after mild traumatic brain injury (mTBI) has progressed the search for objective, diagnostic, and monitoring tools, yet imaging biomarkers mTBI recovery are not established in clinical use. It been suggested that impairs cerebrovascular reactivity (CVR) to CO2, which could be related post-concussive syndrome (PCS). We investigate CVR evolution using blood-oxygen-level dependent (BOLD) magnetic resonance (MRI) possible correlation with PCS.A...
Abstract Introduction We elaborate on existing analysis methods for breath‐hold ( BH )‐derived cerebrovascular reactivity CVR ) measurements and describe novel insights models toward more exact interpretation. Methods Five blood‐oxygen‐level‐dependent BOLD fMRI datasets of neurovascular patients with unilateral hemispheric hemodynamic impairment were used to test various methods. Temporal lag (phase), percent signal change ), explained variance (coherence) maps calculated using three...
For patients with symptomatic unilateral internal carotid artery (ICA) occlusion, impaired cerebrovascular reactivity (CVR) indicates increased stroke risk. Here, the role of collateral activation remains a matter debate, whereas angio-anatomical abundancy does not necessarily imply sufficient compensatory flow provided. We aimed to further elucidate in presence CVR. From prospective database, 62 ICA occlusion underwent blood oxygenation-level dependent (BOLD) fMRI CVR imaging and...
Abstract Crossed cerebellar diaschisis (CCD) in internal carotid artery (ICA) stroke refers to attenuated blood flow and energy metabolism the contralateral hemisphere. CCD is associated with an interruption of cerebro-cerebellar tracts, but precise mechanism unknown. We hypothesized that patients ICA occlusions, might indicate severe hemodynamic impairment addition tissue damage. Duplex sonography clinical data from unilateral ICAO who underwent oxygen-level-dependent MRI cerebrovascular...
Background Comprehensive hemodynamic impairment mapping using blood oxygenation‐level dependent (BOLD) cerebrovascular reactivity (CVR) can be used to identify hemodynamically relevant symptomatic unilateral carotid artery disease. Methods and Results This prospective cohort study was conducted between February 2015 July 2020 at the Clinical Neuroscience Center of University Hospital Zurich, Switzerland. One hundred two patients with newly diagnosed internal (ICA) occlusion or 70% 99% ICA...
Capturing adverse events reliably is paramount for clinical practice and research alike. In the era of "big data", prospective registries form basis quality improvement.
This study aims to elucidate psychosocial and injury features contributing SI following concussion or mild traumatic brain (mTBI) the time course for its development. Between 1998 2012, a sample of 871 patients referred follow-up clinic after treatment in an urban tertiary care ED were consecutively offered enrollment at 3 months post injury. Data from psychiatric social-demographic assessments collected 2 visits (3 6 injury) respectively. Chi-square t-tests performed identify associations...
The clinical significance of ipsilateral thalamic diaschisis (ITD) occurring after stroke is unknown. To characterize ITD, we investigate its hemodynamic, structural, and implications. A single-institution prospective cross-sectional study was conducted using 28 symptomatic cerebrovascular steno-occlusive patients undergoing both BOLD-CVR Diamox-challenged 15 (O)-H 2 O-PET. Follow-up at least three months. In addition, age-matched healthy subjects were included. ITD diagnosed based on a...
Background In patients with steno‐occlusive disease, recent findings suggest that hemodynamic alterations may also be associated crossed cerebellar diaschisis (CCD) rather than a functional disruption alone. Purpose To use quantitative multiparametric MRI to gain better understanding of changes related CCD in unilateral anterior circulation stroke. Study Type Prospective cohort study. Population Twenty‐four (25 datasets) symptomatic Field Strength/Sequence 3T/two sequences: single‐shot...