A5057906372- Intracranial Aneurysms: Treatment and Complications
- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Traumatic Brain Injury and Neurovascular Disturbances
- Meningioma and schwannoma management
- Neurosurgical Procedures and Complications
- Scoliosis diagnosis and treatment
- Pituitary Gland Disorders and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Vascular Malformations Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- Medical Imaging and Analysis
- Clinical practice guidelines implementation
- Intracerebral and Subarachnoid Hemorrhage Research
- Head and Neck Surgical Oncology
- Cerebral Venous Sinus Thrombosis
- Adrenal and Paraganglionic Tumors
- Pregnancy-related medical research
- Growth Hormone and Insulin-like Growth Factors
- Cervical and Thoracic Myelopathy
- Congenital Heart Disease Studies
- Spinal Fractures and Fixation Techniques
- Sinusitis and nasal conditions
- Advanced Neuroimaging Techniques and Applications
- Artificial Intelligence in Healthcare and Education
University of Zurich
2017-2025
University Hospital of Zurich
2017-2025
Stanford University
2023-2024
University Hospital and Clinics
2023-2024
Kantonsspital St. Gallen
2018-2023
Stanford Medicine
2023
University of St. Gallen
2019-2022
Center for Neurosciences
2020
Medical University of Vienna
2018
University Hospital of Bern
2018
Background and Purpose— To identify predictors of in-hospital mortality in patients with aneurysmal subarachnoid hemorrhage to estimate their impact. Methods— Retrospective analysis prospective data from a nationwide multicenter registry on all cases admitted tertiary neurosurgical department Switzerland (Swiss SOS [Swiss Study Aneurysmal Subarachnoid Hemorrhage]; 2009–2015). Both clinical radiological independent were identified, effect size was determined by calculating adjusted odds...
Background and Purpose: The purpose of this study was to assess nationwide incidence outcomes aneurysmal subarachnoid hemorrhage (aSAH). Swiss SOS (Swiss Study on Subarachnoid Hemorrhage) established in 2008 offers the unique opportunity provide data from point care a level. Methods: All patients with confirmed admitted between January 1, 2009 December 31, 2014, within Switzerland were recorded prospective registry. Incidence rates calculated based time-matched population data. Admission...
Objective: In the digital age, patients turn to online sources for lumbar spine fusion information, necessitating a careful study of large language models (LLMs) like chat generative pre-trained transformer (ChatGPT) patient education.Methods: Our aims assess response quality Open AI (artificial intelligence)’s ChatGPT 3.5 and Google’s Bard questions on surgery. We identified 10 critical from 158 frequently asked ones via Google search, which were then presented both chatbots. Five blinded...
OBJECTIVE Gross-total resection (GTR) is often the primary surgical goal in transsphenoidal surgery for pituitary adenoma. Existing classifications are effective at predicting GTR but hampered by limited discriminatory ability moderate cases and poor interrater agreement. Deep learning, a subset of machine has recently established itself as highly forecasting medical outcomes. In this pilot study, authors aimed to evaluate utility using deep learning predict after METHODS Data from...
OBJECTIVE Although rates of postoperative morbidity and mortality have become relatively low in patients undergoing transnasal transsphenoidal surgery (TSS) for pituitary adenoma, cerebrospinal fluid (CSF) fistulas remain a major driver morbidity. Persistent CSF harbor the potential headache meningitis. The aim this study was to investigate whether neural network–based models can reliably identify at high risk intraoperative leakage. METHODS From prospective registry, who underwent...
The Barrow Neurological Institute (BNI) scale is a novel quantitative measuring maximal subarachnoid hemorrhage (SAH) thickness to predict delayed cerebral ischemia (DCI). This could replace the Fisher score, which was traditionally used for DCI prediction. To validate BNI scale. All patient data were obtained from prospective aneurysmal SAH multicenter registry. In 1321 patients, demographic data, scale, DCI, and modified Rankin Scale (mRS) score up 1-yr follow-up (1FU) available...
Objective functional measures such as the 6-minute walking test (6WT) are increasingly applied to evaluate patients with degenerative diseases of lumbar spine before and after (surgical) treatment. However, traditional 6WT is cumbersome apply, it requires specialized in-hospital infrastructure personnel. The authors set out compare distance (6WD) measurements obtained a newly developed smartphone application (app) those gold-standard wheel (DW).
OBJECT The underlying mechanisms causing intracranial perianeurysmal edema (PAE) are still poorly understood. Since PAE is most frequently observed in giant aneurysms (GIAs), the authors designed a study to examine occurrence of relation location, size, and partial thrombosis (PT) GIAs along with clinical impact PAE. METHODS Magnetic resonance imaging data for patients diagnosis unruptured GIA from international multicenter Giant Intracranial Aneurysm Registry were retrospectively analyzed...
Prospective observational cohort study.The aim of this study was to provide external validation the minimum clinically important difference (MCID) Timed-up-and-go (TUG) test.The TUG test is one best explored and most frequently applied objective task-based functional outcome measure in patients with lumbar degenerative disc disease (DDD). The increased use based on its solid psychometric properties; however, an originally determined MCID lacking.Forty-nine DDD, scheduled for elective spine...
This paper analyzes the regulatory frameworks for artificial intelligence/machine learning AI/ML-enabled medical devices in European Union (EU), United States (US), and Republic of Korea, with a focus on applications spine surgery. The aim is to provide guidance developers researchers navigating pathways. A review current literature, documents, legislative was conducted. Key differences bodies, risk classification, submission requirements, approval pathways AI/ML were examined EU, US, Korea....
OBJECTIVE Patient-reported outcome measures (PROMs) are standard of care for the assessment functional impairment. Subjective increasingly complemented by objective ones, such as “Timed Up and Go” (TUG) test. Currently, only a few studies report pre- postoperative TUG test assessments in patients with lumbar spinal stenosis (LSS). METHODS A prospective two-center database was reviewed to identify LSS who underwent decompression or without fusion. The subjective status estimated using PROMs...
Digital transformation enables new possibilities to assess objective functional impairment (OFI) in patients with lumbar degenerative disc disease (DDD). This study examines the psychometric properties of an app-based 6-minute walking test (6WT) and determines OFI DDD.
Abstract Background Indications and outcomes in lumbar spinal fusion for degenerative disease are notoriously heterogenous. Selected subsets of patients show remarkable benefit. However, their objective identification is often difficult. Decision-making may be improved with reliable prediction long-term each individual patient, improving patient selection avoiding ineffective procedures. Methods Clinical models functional impairment [Oswestry Disability Index (ODI) or Core Outcome Measures...
Background and Purpose—Commonly used tools to determine functional outcome after aneurysmal subarachnoid hemorrhage (aSAH) have limitations. Time spent at the patient’s home has previously been proposed as a robust measure ischemic stroke. Here, we set out validate home-time an aSAH. Methods—We examined prospectively collected data from nationwide multicenter registry of aSAH patients admitted tertiary neurosurgical department in Switzerland (Swiss SOS [Swiss Study on Aneurysmal Subarachnoid...
An epileptic seizure is the most common clinical manifestation of a primary brain tumor. Due to modern neuroimaging, detailed anatomical information on tumor available early in diagnostic process and therefore carries considerable potential decision making. The goal this study was gain better understanding relevance characteristics prevalence semiology.We reviewed prospectively collected imaging data all patients operated supratentorial intraparenchymal at our department between January 2009...
OBJECTIVE The 6-minute walking test (6WT) is used to determine restrictions in a subject’s distance (6WD) due lumbar degenerative disc disease. To facilitate simple and convenient patient self-measurement, free reliable smartphone app using Global Positioning System coordinates was previously designed. authors aimed normative values for app-based 6WD measurements. METHODS maximum determined three times measurement sample of 330 volunteers without previous spine surgery or current...
Current prognostic tools in aneurysmal subarachnoid hemorrhage (aSAH) are constrained by being primarily based on patient and disease characteristics admission.To develop validate a complication- treatment-aware outcome prediction tool aSAH.This cohort study included data from an ongoing prospective nationwide multicenter registry all aSAH patients Switzerland (Swiss SOS [Swiss Study aSAH]; 2009-2015). We trained supervised machine learning algorithms to predict binary at discharge (modified...
Outcome assessments after surgery for degenerative lumbar disorders (DLDs) rely on subjective patient-reported outcomes (PROMs). New objective functional capacity tests, like the smartphone-based 6-min walking test (6WT), have been introduced but presumably also do not reflect patient's real-life performance.Pilot study to analyze changes in activity data physical performance outcome patients undergoing DLD.Prospective observational of DLD patients. Objective and were measured using 6WT...
BACKGROUND: Giant intracranial aneurysms (GIAs), which are defined as (IAs) with a diameter of ≥25 mm, most likely associated the highest treatment costs all IAs. However, unruptured GIAs have so far not been reported. OBJECTIVE: To examine direct endovascular and surgical GIAs. METHODS: We retrospectively examined 55 patients treated surgically (37 patients) or endovascularly (18 between April 2004 March 2014. analyzed hospital stays, interventions, imaging median follow-up 46 months....