A5057096729- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurosurgical Procedures and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Vascular Malformations Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Head and Neck Surgical Oncology
- Meningioma and schwannoma management
- Augmented Reality Applications
- Spinal Fractures and Fixation Techniques
- Spinal Dysraphism and Malformations
- Cardiac, Anesthesia and Surgical Outcomes
- Spine and Intervertebral Disc Pathology
- Surgical Simulation and Training
- Glioma Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Anatomy and Medical Technology
- Moyamoya disease diagnosis and treatment
- Cerebral Venous Sinus Thrombosis
- Infective Endocarditis Diagnosis and Management
- Assisted Reproductive Technology and Twin Pregnancy
- Cervical and Thoracic Myelopathy
- Craniofacial Disorders and Treatments
University Hospital of Zurich
2014-2024
University of Zurich
2018-2024
Cereneo
2024
University Medical Center Utrecht
2015-2022
FACET Innovations (United States)
2022
Utrecht University
2022
Amsterdam Neuroscience
2022
Center for Neurosciences
2022
Spital Limmattal
2021
Medical University of Vienna
2021
Background and Purpose— To identify predictors of in-hospital mortality in patients with aneurysmal subarachnoid hemorrhage to estimate their impact. Methods— Retrospective analysis prospective data from a nationwide multicenter registry on all cases admitted tertiary neurosurgical department Switzerland (Swiss SOS [Swiss Study Aneurysmal Subarachnoid Hemorrhage]; 2009–2015). Both clinical radiological independent were identified, effect size was determined by calculating adjusted odds...
Background and Purpose— Patients are classically at risk of delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage. We validated a grading scale—the VASOGRADE—for prediction DCI. Methods— used data 3 phase II randomized clinical trials single hospital series to assess the relationship between VASOGRADE The derived from previously published charts consists categories: VASOGRADE-Green (modified Fisher scale 1 or 2 World Federation Neurosurgical Societies [WFNS] 2);...
Abstract Background A frequent complication in patients with subarachnoid hemorrhage (SAH) is recurrent bleeding from the aneurysm. The risk highest within first 6 hours after initial hemorrhage. Securing aneurysm this timeframe difficult owing to logistical delays. rate of can also be reduced by ultra-early administration antifibrinolytics, which probably improves functional outcome. aim study investigate whether and short-term antifibrinolytic agent tranexamic acid (TXA), as add-on...
Impaired cerebrovascular reactivity (CVR) has been correlated with recurrent ischemic stroke. However, for clinical purposes, most CVR techniques are rather complex, time-consuming, and lack validation quantitative measurements. The recent adaptation of a standardized hypercapnic stimulus in combination blood-oxygenation-level-dependent (BOLD) magnetic resonance imaging signal as surrogate cerebral blood flow offers potential universally comparable assessment. We investigated the association...
The results of the ULTRA trial showed that ultra-early and short-term treatment with tranexamic acid (TXA) does not improve clinical outcome after aneurysmal subarachnoid hemorrhage (aSAH). Possibly, lack a beneficial effect in all patients aSAH is masked by antagonistic effects TXA certain subgroups. In this post hoc subgroup analysis, we investigated on good-grade poor-grade aSAH.
OBJECTIVEThe aim of this study was to create prediction models for outcome parameters by decision tree analysis based on clinical and laboratory data in patients with aneurysmal subarachnoid hemorrhage (aSAH).METHODSThe database consisted 548 aSAH who were admitted the Neurocritical Care Unit, University Hospital Zurich. To examine model performance, cohort randomly divided into a derivation (60% [n = 329]; training set) validation (40% 219]; test set). The classification regression...
OBJECTIVE In this study the authors sought to investigate sex differences in risk of delayed cerebral ischemia (DCI), infarction, and role hormonal status. METHODS Ten studies included SAHIT (SAH International Trialists) repository were analyzed using a fitting logistic regression model. Heterogeneity between was tested I2 statistics, results pooled random-effects Multivariable analysis adjusted for effects neurological status fixed effect study. An additional model examined which women men...
The choice between posterior cervical foraminotomy (posterior surgery) and anterior discectomy with fusion (anterior for foraminal radiculopathy remains controversial.To investigate the noninferiority of vs surgery in patients regard to clinical outcomes after 1 year.This multicenter investigator-blinded randomized trial was conducted from January 2016 May 2020 a total follow-up 2 years. Patients were included 9 hospitals Netherlands. Of 389 adult 1-sided single-level screened eligibility,...
BACKGROUND: Incisional cerebrospinal fluid (iCSF) leakage is a serious complication after intradural cranial surgery. OBJECTIVE: To determine the incidence and risk factors of iCSF craniotomy. Secondarily, complications success rate treatment was studied. METHODS: All patients who underwent an surgery from 2017 to 2018 at 5 neurosurgical centers were retrospectively included. Data retrieved medical records with 2 months follow-up. First, univariate regression analyses performed....
<h3>Objective:</h3> We studied the yield of MRI spinal neuraxis in patients with nonperimesencephalic subarachnoid hemorrhage (NPSAH). <h3>Methods:</h3> In a prospective, multicenter study, we performed T1-weighted and T2-weighted axis consecutive series spontaneous NPSAH without intracranial vascular pathology on imaging. <h3>Results:</h3> A origin was found 3 75 (4%; 95% confidence interval 0–8.4). The lesions were 1 lumbar ependymoma 2 cervical cavernous malformations. All presented focal...
Background Recurrent bleeding is one of the major causes morbidity and mortality in patients with aneurysmal subarachnoid hemorrhage (aSAH). Antifibrinolytic therapy known to reduce recurrent bleeding, however, its beneficial effect on outcome remains unclear. The treatment tranexamic acid (TXA) until aneurysm clinical evaluated. Methods Patients an aSAH from two high-volume tertiary referral centers Netherlands, Academic Medical Center (AMC) Radboud University (RUMC), between January 2012...
The aesthetic outcome after burr hole trepanation for the evacuation of chronic subdural hematomas (cSDH) is often unsatisfactory, as bony skull defects may cause visible skin depressions. purpose this study was to evaluate efficacy cover placement improve outcome. We reviewed consecutive patients treated by cSDH with or without covers a single surgeon between October 2016 and May 2018. clinical data, including complications, were derived from institution's prospective patient registry....
Capturing adverse events reliably is paramount for clinical practice and research alike. In the era of "big data", prospective registries form basis quality improvement.
Abstract Objective The recent guidelines on management of aneurysmal subarachnoid hemorrhage (aSAH) advise pharmacological thromboprophylaxis (PTP) after aneurysm obliteration. However, no study has addressed the safety PTP in aSAH population. Therefore, aim this was to assess early aSAH. Methods Retrospective cohort patients admitted between January 2012 and June 2013 a single high-volume center. Traumatic SAH perimesencephalic were excluded. Patients grouped according timing: group (PTP...
The Barrow Neurological Institute (BNI) score, measuring maximal thickness of aneurysmal subarachnoid hemorrhage (aSAH), has previously shown to predict symptomatic cerebral vasospasms (CVSs), delayed ischemia (DCI), and functional outcome.To validate the BNI score for prediction above-mentioned variables infarct evaluate its improvement by integrating further which are available within first 24 h after hemorrhage.We included patients from a single center. CVS, DCI, infarct, outcome was...