A5045726522- Glioma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Meningioma and schwannoma management
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer Immunotherapy and Biomarkers
- vaccines and immunoinformatics approaches
- Pituitary Gland Disorders and Treatments
- Brain Metastases and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebrospinal fluid and hydrocephalus
- CAR-T cell therapy research
- Head and Neck Surgical Oncology
- Vascular Malformations Diagnosis and Treatment
- Parathyroid Disorders and Treatments
- Neurosurgical Procedures and Complications
- Cardiac, Anesthesia and Surgical Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Peptidase Inhibition and Analysis
- RNA Interference and Gene Delivery
- Immune cells in cancer
- Intraoperative Neuromonitoring and Anesthetic Effects
- Genetic Syndromes and Imprinting
- Cerebrovascular and Carotid Artery Diseases
- Monoclonal and Polyclonal Antibodies Research
University of Zurich
2016-2025
University Hospital of Zurich
2016-2025
University of St. Gallen
2013-2025
Kantonsspital St. Gallen
2018-2024
ETH Zurich
2019-2023
Swiss Epilepsy Center
2021
Center for Neurosciences
2020
Broad Institute
2020
Center for Cancer Research
2020
Harvard University
2020
Background The human leucocyte antigen (HLA) complex controls adaptive immunity by presenting defined fractions of the intracellular and extracellular protein content to immune cells. Understanding benign HLA ligand repertoire is a prerequisite define safe T-cell-based immunotherapies against cancer. Due poor availability tissues, if available, normal tissue adjacent tumor has been used as surrogate when defining tumor-associated antigens. However, this comparison proven be insufficient even...
Meningiomas are the most frequent primary intracranial tumors. Patient outcome varies widely from benign to highly aggressive, ultimately fatal courses. Reliable identification of risk progression for individual patients is pivotal importance. However, only biomarkers aggressive tumors established (CDKN2A/B and TERT), whereas no molecularly based stratification exists broad spectrum with low- intermediate-risk meningioma.DNA methylation data copy-number information were generated 3,031...
Microbial organisms have key roles in numerous physiological processes the human body and recently been shown to modify response immune checkpoint inhibitors
Glioma contains malignant cells in diverse states. Here, we combine spatial transcriptomics, proteomics, and computational approaches to define glioma cellular states uncover their organization. We find three prominent modes of First, gliomas are composed small local environments, each typically enriched with one major state. Second, specific pairs preferentially reside proximity across multiple scales. This pairing is consistent tumors. Third, these pairwise interactions collectively a...
Background and Purpose— To identify predictors of in-hospital mortality in patients with aneurysmal subarachnoid hemorrhage to estimate their impact. Methods— Retrospective analysis prospective data from a nationwide multicenter registry on all cases admitted tertiary neurosurgical department Switzerland (Swiss SOS [Swiss Study Aneurysmal Subarachnoid Hemorrhage]; 2009–2015). Both clinical radiological independent were identified, effect size was determined by calculating adjusted odds...
Surgical excision is the standard treatment for intracranial meningiomas. Epilepsy a major cause of morbidity in meningioma patients, but postoperative control epilepsy not achieved substantial fraction patients. The purpose this study was to define risk factors epilepsy.Patients treated histologically confirmed at University Hospital Zurich between 2000 and 2013 were retrospectively analyzed. Demographic, clinical, imaging, electroencephalographic data assessed. A binary regression model...
Abstract T cell recognition of human leukocyte antigen (HLA)-presented tumor-associated peptides is central for cancer immune surveillance. Mass spectrometry (MS)-based immunopeptidomics represents the only unbiased method direct identification and characterization naturally presented peptides, a key prerequisite development cell-based immunotherapies. This study reports on implementation ion mobility separation-based time-of-flight (TOF IMS ) MS next-generation immunopeptidomics, enabling...
Abstract Treatment with the alkylating agent temozolomide is known to be prognostically beneficial in a subset of glioblastoma patients. Response such chemotherapeutic treatment and prognostic benefit have been linked methylation status O 6 -methylguanine-DNA methyltransferase ( MGMT ). To date, it has not entirely resolved which pattern most relevant predict response outcome. In this retrospective study, we compared patterns, analyzed by Sanger sequencing, 27 isocitrate dehydrogenase IDH...
Abstract Background Brain tumors, whether primary or secondary, have limited therapeutic options despite advances in understanding driver gene mutations and heterogeneity within tumor cells. The cellular molecular composition of brain stroma, an important modifier growth, has been less investigated to date. Only few studies focused on the vasculature human tumors fact that blood-brain barrier (BBB) represents major obstacle for efficient drug delivery. Methods In this study, we employed RNA...
Antigen-specific immunotherapies, in particular peptide vaccines, depend on the recognition of naturally presented antigens derived from mutated and unmutated gene products human leukocyte antigens, represent a promising low-side-effect concept for cancer treatment. So far, broad application vaccines patients is hampered by challenges time- cost-intensive personalized vaccine design, lack neoepitopes tumor-specific mutations, especially low-mutational burden malignancies. In this study, we...
Objective Klotho is a lifespan-influencing gene expressed mainly in the kidneys. Soluble α-Klotho (αKL) released into circulation. In this study, we present baseline αKL serum levels of patients with acromegaly compared controls other pituitary adenomas and assess changes following transsphenoidal surgery. Design Prospective controlled study. Methods We measured soluble (sandwich ELISA) IGF1 (RIA) sera 14 (eight females six males) active 22 control (13 nine operated for non-GH-producing...
The Barrow Neurological Institute (BNI) scale is a novel quantitative measuring maximal subarachnoid hemorrhage (SAH) thickness to predict delayed cerebral ischemia (DCI). This could replace the Fisher score, which was traditionally used for DCI prediction. To validate BNI scale. All patient data were obtained from prospective aneurysmal SAH multicenter registry. In 1321 patients, demographic data, scale, DCI, and modified Rankin Scale (mRS) score up 1-yr follow-up (1FU) available...
OBJECTIVEThe aim of this study was to create prediction models for outcome parameters by decision tree analysis based on clinical and laboratory data in patients with aneurysmal subarachnoid hemorrhage (aSAH).METHODSThe database consisted 548 aSAH who were admitted the Neurocritical Care Unit, University Hospital Zurich. To examine model performance, cohort randomly divided into a derivation (60% [n = 329]; training set) validation (40% 219]; test set). The classification regression...