A5064877730- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Meningioma and schwannoma management
- Cerebrovascular and Carotid Artery Diseases
- Connexins and lens biology
- Trigeminal Neuralgia and Treatments
- Neurosurgical Procedures and Complications
- Dental Anxiety and Anesthesia Techniques
- Neuroscience and Neuropharmacology Research
- Intensive Care Unit Cognitive Disorders
- Nicotinic Acetylcholine Receptors Study
- Spinal Fractures and Fixation Techniques
- Migraine and Headache Studies
- S100 Proteins and Annexins
- Glioma Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- Brain Metastases and Treatment
- Radiation Dose and Imaging
- Facial Nerve Paralysis Treatment and Research
- Drug-Induced Hepatotoxicity and Protection
- Bone health and osteoporosis research
- Trauma and Emergency Care Studies
- Biochemical effects in animals
- Moyamoya disease diagnosis and treatment
- Neuroblastoma Research and Treatments
University Medical Centre Mannheim
2017-2024
Heidelberg University
2017-2024
University Hospital Heidelberg
2017-2024
Düsseldorf University Hospital
2016
Heinrich Heine University Düsseldorf
2012-2016
Ruhr University Bochum
2011-2014
University Hospital of Bern
2012
Brain (Germany)
2011-2012
BG University Hospital Bergmannsheil Bochum
2010
We endeavored to develop an unruptured intracranial aneurysm (UIA) treatment score (UIATS) model that includes and quantifies key factors involved in clinical decision-making the management of UIAs assess agreement for this among specialists UIA research.
Pannexin 1 (Panx1) represents a class of vertebrate membrane channels, bearing significant sequence homology with the invertebrate gap junction proteins, innexins and more distant similarities in topologies pharmacological sensitivities proteins connexin family. In nervous system, cooperation among pannexin adenosine receptors, KATP channels modulating neuronal excitability via ATP has been recognized, but little is known about significance vivo. However, localization Panx1 at postsynaptic...
OBJECTIVE Methods of choice for neurophysiological intraoperative monitoring (IOM) within the infratentorial compartment mostly include early brainstem auditory evoked potentials, free-running electromyography, and direct cranial nerve (CN) stimulation. Long-tract with somatosensory potentials (SEPs) motor (MEPs) is rarely used. This study investigated incidence IOM alterations during posterior fossa surgery stratified lesion location. METHODS Standardized CN SEP/MEP was performed in 305...
Background and Purpose- Determinants for molecular structural instability, that is, impending growth or rupture, of intracranial aneurysms (IAs) remain uncertain. To elucidate this, we endeavored to estimate the actual turnover rates main constituent in human IA (collagen) on basis radiocarbon (14C) birth dating relation hemodynamics. Methods- Collagen excised samples were calculated using mathematical modeling 14C data collagen risk factors histological markers maturity/turnover selected...
BACKGROUND AND OBJECTIVES: Acute hydrocephalus after aneurysmal subarachnoid hemorrhage (SAH) is typically treated by external ventricular drainage (EVD), which carries a risk of complications and long-term shunt dependency. Lumbar puncture (LP) may be an alternative. We compared the efficacy safety LP EVD as initial treatment for acute SAH. METHODS: performed 2-center cohort study comparing 2 different institutional approaches, with either or treatment. Patients SAH within 72 hours...
Abstract Background Glioblastoma is the most common and malignant brain tumor in adults. usually fatal 12–15 months after diagnosis current possibilities therapy are mostly only palliative. Therefore, new forms of urgently needed. Since tumor‐associated macrophages key players progression survival there large potential investigating their immunological characteristics glioblastoma patients. Recent evidence shows expression variable immunoglobulins TCRαβ subpopulations monocytes, vitro...
Background and Purpose Prediction of intracranial aneurysm growth risk can assist physicians in planning follow-up imaging conservatively managed unruptured aneurysms. We therefore aimed to externally validate the ELAPSS (Earlier subarachnoid hemorrhage, Location, Age, Population, Size Shape) score for prediction growth. Methods From 11 international cohorts patients ≥18 years with ≥1 ≥6 months radiological follow-up, we collected data on predictors score, calculated 3- 5-year absolute risks...
Background. The COVID-19 pandemic has seriously impacted healthcare systems worldwide. Admissions for various non-COVID-19 emergencies have significantly decreased. We sought to determine the impact of on admissions intracranial hemorrhage a German University Hospital emergency department. Methods. In retrospective analysis department Mannheim from January June 2020 and corresponding time period in 2019, all patients admitted either traumatic or non-traumatic were evaluated. Poisson...
Objective Although sepsis and delayed cerebral ischemia (DCI) are severe complications in patients with aneurysmal subarachnoid hemorrhage (aSAH) share pathophysiological features, their interrelation additive effect on functional outcome is uncertain. We investigated the association between DCI cumulative aSAH using current sepsis-3 definition. Methods Patients admitted to our hospital 11/2014 11/2018 for were retrospectively analyzed. The main explanatory variable was sepsis, diagnosed...
Patients undergoing craniotomies necessitating preparation of the temporal muscle (TM) may experience postoperative functional impairment temporomandibular joint. This topic has not been thoroughly discussed in literature so far. In present study, authors propose a questionnaire as an evaluation tool to assess what degree different TM techniques correlate with joint dysfunction.Between 2004 and 2006, 286 patients underwent either pterional or department at University Münster Germany....
<b><i>Background:</i></b> The invasiveness and risk of thromboembolic complications catheter angiography underline the need for alternative imaging modalities in patients following intracranial aneurysm (IA) repair. However, overall image quality existing noninvasive modalities, such as single-energy CT (SE-CTA), compromises its value this respect. <b><i>Objective:</i></b> We prospectively investigated a novel dual-energy CTA (DE-CTA) scanner...
The appropriate management of delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH) remains uncertain. We aimed to evaluate the effect implementing a standardized protocol for detection and DCI aSAH on infarction functional outcome. studied two cohorts patients, one before (pre-implementation cohort: January 2012 August 2014) (post-implementation 2016 July 2018) implementation multidisciplinary approach, with neurological radiological assessment risk-based medical...
Decompressive craniectomy (DC) can alleviate increased intracranial pressure in aneurysmal subarachnoid hemorrhage patients with concomitant space-occupying intracerebral hemorrhage, but also carries a high risk for complications. We studied outcomes and complications of DC at time ruptured aneurysm repair.
Data on sepsis in patients with a subarachnoid hemorrhage (SAH) are scarce. We assessed the impact of different criteria outcome an SAH cohort. Adult admitted to our ICU spontaneous between 11/2014 and 11/2018 were retrospectively included. In developing infection, for diagnosis (Sepsis-1, Sepsis-3_original, Sepsis-3_modified accounting SAH-specific therapy, alternative compiled consensus conferences) applied their functional using modified Rankin Scale (mRS) hospital discharge in-hospital...
Preclinical studies provided a strong rationale for pathophysiological link between cell-free hemoglobin in the cerebrospinal fluid (CSF-Hb) and secondary brain injury after subarachnoid hemorrhage (SAH-SBI). In single-center prospective observational clinical study, external ventricular drain (EVD) based CSF-Hb proved to be promising biomarker monitor SAH-SBI. The primary objective of HeMoVal study is prospectively validate association EVD SAH-SBI during first 14 days post-SAH. Secondary...
Pannexin 1 (Panx1) represents a class of vertebrate membrane channels, bearing significant sequence homology with the invertebrate gap junction proteins, innexins and more distant similarities in topologies pharmacological sensitivities proteins connexin family.In nervous system, cooperation among pannexin adenosine receptors, K ATP channels modulating neuronal excitability via has been recognized, but little is known about significance vivo.However, localization Panx1 at postsynaptic sites...