A5090978677- Dementia and Cognitive Impairment Research
- Health, Environment, Cognitive Aging
- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Traumatic Brain Injury and Neurovascular Disturbances
- Nutritional Studies and Diet
- Neurosurgical Procedures and Complications
- Cardiovascular Health and Risk Factors
- Intracerebral and Subarachnoid Hemorrhage Research
- Intracranial Aneurysms: Treatment and Complications
- Health Systems, Economic Evaluations, Quality of Life
- Frailty in Older Adults
- Atrial Fibrillation Management and Outcomes
- Genetic Associations and Epidemiology
- Blood Pressure and Hypertension Studies
- Atherosclerosis and Cardiovascular Diseases
- Chemokine receptors and signaling
- Biomedical Text Mining and Ontologies
- Health Literacy and Information Accessibility
- Chronic Kidney Disease and Diabetes
- Vascular Malformations Diagnosis and Treatment
- S100 Proteins and Annexins
- Health disparities and outcomes
- Nutrition and Health in Aging
- Cerebrovascular and genetic disorders
Massachusetts General Hospital
2024-2025
Broad Institute
2024-2025
University Medical Center Utrecht
2019-2025
Harvard University
2025
Utrecht University
2019-2025
Brigham and Women's Hospital
2025
Center for Pain and the Brain
2025
Abstract Background Previous work has shown a role of CCL2, key chemokine governing monocyte trafficking, in atherosclerosis. However, it remains unknown whether targeting CCR2, the cognate receptor provides protection against human atherosclerotic cardiovascular disease. Methods Computationally predicted damaging or loss-of-function (REVEL > 0.5) variants within CCR2 were detected whole-exome-sequencing data from 454,775 UK Biobank participants and tested for association with endpoints...
Background Stroke and dementia are leading causes of mortality can be prevented through risk factor management. Risk assessment requires laboratory or physical measurements. We aimed to determine whether self‐reported factors serve as reliable proxies predict stroke‐ dementia‐related mortality. Methods Results used cross‐sectional data from the NHANES (National Health Nutrition Examination Survey) 1999 2018 linked National Death Index records. included participants with available on measured...
Introduction: Food insecurity, defined as limited access to nutritious food due financial challenges, has grown substantially over the past two decades in United States. Stroke survivors are more likely experience insecurity compared general population. However, impact of on long-term survival post-stroke remains unclear. Hence, we aimed determine associations between and all-cause mortality. Methods: The National Health Nutrition Examination Survey (NHANES) is an iterative cross-sectional...
Background: Trust in healthcare information sources, specifically professionals (HCPs) influences people’s health-related knowledge and behaviors. Epidemiological studies demonstrate that approximately 45% of dementia 60% stroke risks are attributable to modifiable risk factors. However, limited data exist on associations between trust levels HCPs perceptions the modifiability from a United States cohort. Methods: We developed survey based validated questionnaires distributed it cohort all...
Background: Dementia and stroke are major contributors to mortality morbidity, largely due modifiable risk factors. Despite widespread awareness, health-related behaviors that reduce these risks remain suboptimal. This study aims (i) cluster characterize subgroups based on their recognition of factors associated for dementia stroke, (ii) identify the corresponding facilitators barriers. Methods: We conducted an online survey U.S. population via Prolific. Participants were assessed...
Background: The Brain Care Score (BCS) is a novel tool developed to address modifiable risk factors for the incidence of age-related brain diseases such as stroke, dementia, and late-life depression (LLD) (Fig 1) . Previous data showed that lower baseline BCS associated with higher disease risks. This study examines associations between longitudinal changes on these three outcomes. Methods: UK Biobank (UKB) participants primary care available assessment 19-point modified were included. We...
Introduction: Stroke and dementia are among the leading causes of mortality globally. This can be mitigated through targeting modifiable risk factors. Identification those at-risk screening tools could facilitated by inclusion self-reported factors rather than reliance on clinical data. We aimed to determine whether reliable in identifying individuals predict stroke dementia-related mortality. Methods: In this study cross-sectional data from National Health Nutrition Examination Survey...
Introduction: Of all strokes, 25% are attributable to recurrent events, of which 80% can be prevented by adherence secondary prevention guidelines. These involve managing and controlling risk factors for recurrence, such as blood pressure, body mass index (BMI), low-density lipoprotein (LDL) cholesterol, glycated hemoglobin (HbA1c), smoking, alcohol consumption physical activity. We aimed determine proportion stroke survivors adheres standard AHA guidelines factor management, the trends in...
Introduction: Atrial fibrillation diagnosed after stroke (AFDAS) is common and differs from known atrial (KAF), the most cause of cardioembolic stroke. Because identification AFDAS warrants administration oral anticoagulants for secondary prevention, extended cardiac monitoring often used, yet it unclear who at risk developing AFDAS. We aimed to determine whether prediction improves when adding genetic clinical predictors in a real world population survivors. Methods: retrospectively...
Introduction: Stroke, dementia, and late-life depression (LLD) are age-related brain diseases that pose significant public health challenges. Leukocyte telomere length (LTL), a proposed marker of biological age influenced by complex interplay both lifestyle heritable factors, may offer valuable insights into the modifiability risk for these diseases. We aimed to study association between LTL three outcomes, whether healthy choices modify this risk. Methods: utilized data from UK Biobank...
Background: Since treatment with anticoagulants can prevent recurrent strokes, identification of patients at risk for incident AF after stroke is crucial. We aimed to investigate whether the addition polygenic scores (PRS) existing clinical predictors could improve prediction stroke. Methods: Patients diagnosed ischemic Massachusetts General Hospital between 2003-2017 were included. Clinical was estimated using Re-CHARGE-AF model and genetic a contemporary PRS from 1,093,050 variants....
ABSTRACT Aim Stroke is a leading cause of death and disability, with substantial healthcare implications. Chronic kidney disease (CKD) similarly impactful, emerging evidence links CKD to higher stroke risk. Despite this, risk assessment in patients remains limited. This study explores the failure equation (KFRE) as predictive tool for ischaemic patients. Methods retrospective cohort analysed from registry, excluding those prior stroke, end‐stage disease, or transplants. Acute ischemic was...
Introduction: Whether stroke survivors can meet risk factor recommendations set by guidelines is unknown. We investigated the proportion of that met secondary prevention guideline recommendations, analyzed trends over time, and assessed impact on mortality. Methods: Using cross-sectional data from National Health Nutrition Examination Survey (NHANES) 1999-2018, we determined who recommendations. performed linear regression analyses to determine Cox-proportional hazards models assess Results:...
BACKGROUND AND OBJECTIVES: Acute hydrocephalus after aneurysmal subarachnoid hemorrhage (SAH) is typically treated by external ventricular drainage (EVD), which carries a risk of complications and long-term shunt dependency. Lumbar puncture (LP) may be an alternative. We compared the efficacy safety LP EVD as initial treatment for acute SAH. METHODS: performed 2-center cohort study comparing 2 different institutional approaches, with either or treatment. Patients SAH within 72 hours...
The Brain Care Score (BCS) was developed in partnership with patients and practitioners to convey actionable knowledge individuals everywhere that can motivate change health-related behaviors thereby reduce the risk of dementia, stroke, late-life depression (LLD). Because diseases outside brain share modifiable factors LLD, we investigated associations BCS other common age-related diseases, including cardiovascular disease (CVD) cancer. Among all UK Biobank (UKB) participants complete data,...
The risk of rebleeding is highest during the initial hours after aneurysmal subarachnoid haemorrhage (aSAH), but aneurysm not occluded in all patients immediately admission.Our aim was to determine proportion aSAH with poor outcome from early in-hospital that can be prevented by three emergency occlusion regimes.From our prospectively collected database, we retrieved admitted between July 2007 and 2017 data on clinical condition admission, time rebleeding, at 3 months.Of 1391 consecutive...
External ventricular drainage (EVD) for acute hydrocephalus after aneurysmal subarachnoid haemorrhage (aSAH) carries a risk of complications. We studied the proportion patients in whom EVD can be avoided by treating with ≥1 lumbar punctures (LP).
Introduction: Complement C5 antibodies reduce brain injury after experimental subarachnoid hemorrhage. Patients and methods: In this randomized, controlled, open-label, phase 2a clinical trial with blinded-outcome assessment, we included adult aneurysmal hemorrhage (aSAH) patients admitted to a tertiary referral center ⩽11 h ictus. were randomized (1:1) eculizumab plus care as usual or usual. Eculizumab (1200 mg) was administered <12 h, on days 3 7 the intervention group, all received...
To investigate associations between health-related behaviors as measured using the Brain Care Score (BCS) and neuroimaging markers of white matter injury.