A5102815080- Liver Disease and Transplantation
- Long-Term Effects of COVID-19
- Abdominal vascular conditions and treatments
- COVID-19 Clinical Research Studies
- Sepsis Diagnosis and Treatment
- Dialysis and Renal Disease Management
- Pancreatitis Pathology and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Liver Disease Diagnosis and Treatment
- Electrolyte and hormonal disorders
- Respiratory Support and Mechanisms
- Viral Infections and Immunology Research
- SARS-CoV-2 and COVID-19 Research
- Abdominal Surgery and Complications
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Organ Transplantation Techniques and Outcomes
- Mechanical Circulatory Support Devices
- Influenza Virus Research Studies
- Respiratory viral infections research
- Poisoning and overdose treatments
- Renal and Vascular Pathologies
- Muscle and Compartmental Disorders
- Multiple Sclerosis Research Studies
- Esophageal and GI Pathology
- Infectious Aortic and Vascular Conditions
Medizinische Hochschule Hannover
2017-2024
ERN RARE-LIVER
2020
Robert Koch Institute
2014
Elucidating the role of T cell responses in COVID-19 is utmost importance to understand clearance SARS-CoV-2 infection.
Abstract Background Comprehensive data on the cerebrospinal fluid (CSF) profile in patients with COVID-19 and neurological involvement from large-scale multicenter studies are missing so far. Objective To analyze systematically CSF COVID-19. Methods Retrospective analysis of 150 lumbar punctures 127 PCR-proven symptoms seen at 17 European university centers Results The most frequent pathological finding was blood-CSF barrier (BCB) dysfunction (median QAlb 11.4 [6.72–50.8]), which present...
Given the pathophysiological key role of host response to an infection rather than per se, ideal therapeutic strategy would also target this response. This study was designed demonstrate safety and feasibility early plasma exchange (TPE) in severely ill individuals with septic shock. a prospective single center, open-label, nonrandomized pilot enrolling 20 patients shock (onset < 12 h) requiring high doses norepinephrine (NE; > 0.4 μg/kg/min) out 231 screened patients. Clinical biochemical...
Abstract Background Multi‐organ dysfunction in acute liver failure (ALF) has been attributed to a systemic inflammatory response directly triggered by the injured liver. High‐volume therapeutic plasma exchange (HV‐TPE) demonstrated large randomized controlled trial improve survival. Here, we investigated if more cost‐/ resource effective low‐volume (LV) TPE strategy might have comparable beneficial effects. Methods This retrospective study evaluated effect of LV‐TPE on remote organ failure,...
Abstract Background Recently, a randomized controlled trial (RCT) demonstrated rapid but individually variable hemodynamic improvement with therapeutic plasma exchange (TPE) in patients septic shock. Prediction of clinical efficacy specific sepsis treatments is fundamental for individualized therapy. Methods In the original RCT, shock < 24 h duration and norepinephrine (NE) requirement ≥ 0.4 μg/kg/min received standard care (SOC) or SOC + one single TPE. Here, we report all biological...
To analyze demography, clinical signs, and survival of intensive care patients diagnosed with nonocclusive mesenteric ischemia (NOMI) to evaluate the effect a local intra-arterial prostaglandin therapy.Retrospective observational study screening 455 acute arterial perfusion disorder in tertiary hospital within past 8 years. Lastly, 32 NOMI were enrolled, which 11 received therapy. The diagnosis was based on presentation established biphasic computed tomography criteria. Clinical biochemical...
Abstract Background Non-occlusive mesenteric ischemia (NOMI) is a life-threatening condition occurring in patients with shock and characterized by vasoconstriction of the arteries leading to intestinal multi-organ failure. Although minimal invasive local intra-arterial infusion vasodilators into circulation has been suggested as therapeutic option NOMI, current knowledge based on retrospective case series it remains unclear which might benefit. Here, we prospectively analyzed predictors...
Abstract Background Acute on chronic liver failure (ACLF) has been identified as a distinct syndrome due to acute decompensation of cirrhosis accompanied by extra‐hepatic organ failure, primarily caused an overwhelming systemic immune response. Therapeutic plasma exchange (TPE) demonstrated in randomized controlled trial improve transplant free survival failure. Here we investigated if TPE might have comparable beneficial effects patients with ACLF. Methods Thirty‐one ACLF that were treated...
Abstract Purpose To evaluate the feasibility of 2D-perfusion angiography (2D-PA) for analysis intra-procedural treatment response after intra-arterial prostaglandin E1 therapy in patients with non-occlusive mesenteric ischemia (NOMI). Methods Overall, 20 procedures 18 NOMI were included this retrospective case–control study. splanchnic circulation changes, post-processing digital subtraction (DSA) series was performed. Regions interest (ROIs) placed superior artery (SMA; reference), portal...
Background: Elucidating the role of T cell responses in COVID-19 is utmost importance to understand clearance SARS-CoV-2 infection. Methods: 90 individuals were enrolled this study, 30 hospitalized patients and 60 age- gender-matched healthy controls (HC). Using two comprehensive 11-color flow cytometric panels conforming Good Laboratory Practice (GLP) approved for clinical diagnostics, we longitudinally examined count differences lymphocyte populations activation patients. Findings:...
In a patient with severe status asthmaticus, enoximone, phosphodiesterase-3 inhibitor, caused immediate bronchodilation http://bit.ly/38UYpUn.
The impact of immunosuppression on outcomes in influenza is insufficiently understood. We analyzed the morbidity and mortality immunocompetent (IC) vs immunosuppressed (IS) patients with A B 2017/2018 season. Patients proven a German tertiary care hospital were for hospitalization, intensive unit (ICU) admission, mortality. Causes IS organ bone marrow transplantation, AIDS, chemotherapy, medical immunosuppression. In total, 227 included this analysis (IC, n = 118 [52%]; IS, 109 [48%])....
<b>Background:</b> Impact of immunosuppression on outcomes in influenza is insufficiently understood. <b>Aims and Objectives:</b> To analyze morbidity mortality immunocompetent (IC) vs immunosuppressed (IS) patients with A B the 2017/2018 epidemic. <b>Methods:</b> 231 infection evaluated a German tertiary care hospital were analyzed retrospectively for hospitalization, intensive unit (ICU) admission mortality. IS either organ transplant recipients or chemotherapy. <b>Results:</b> In total,...