Axel Petzold
A5061751725- Multiple Sclerosis Research Studies
- Glaucoma and retinal disorders
- Retinal and Optic Conditions
- Traumatic Brain Injury and Neurovascular Disturbances
- Ocular Diseases and Behçet’s Syndrome
- Systemic Lupus Erythematosus Research
- Retinal Diseases and Treatments
- Peripheral Neuropathies and Disorders
- Amyotrophic Lateral Sclerosis Research
- Retinal Imaging and Analysis
- Cerebral Venous Sinus Thrombosis
- S100 Proteins and Annexins
- Ophthalmology and Eye Disorders
- Skin and Cellular Biology Research
- Optical Coherence Tomography Applications
- Retinal Development and Disorders
- Cerebrospinal fluid and hydrocephalus
- Hereditary Neurological Disorders
- Ophthalmology and Visual Impairment Studies
- Intracranial Aneurysms: Treatment and Complications
- Prion Diseases and Protein Misfolding
- Parkinson's Disease Mechanisms and Treatments
- Neurosurgical Procedures and Complications
- Neurogenetic and Muscular Disorders Research
- Neurogenesis and neuroplasticity mechanisms
National Hospital for Neurology and Neurosurgery
2016-2025
University College London
2016-2025
Moorfields Eye Hospital
2016-2025
Moorfields Eye Hospital NHS Foundation Trust
2004-2025
National Institute for Health Research
2018-2025
Amsterdam Neuroscience
2016-2024
Amsterdam University Medical Centers
2018-2024
Amsterdam UMC Location VUmc
2012-2024
Klinik und Poliklinik für Frauenheilkunde und Fortpflanzungsmedizin
2020-2024
University Medical Center Utrecht
2024
There is a long history of research into body fluid biomarkers in neurodegenerative and neuroinflammatory diseases. However, only few CSF are being used clinical practice. One the most critical factors biomarker inadequate powering studies because lack sufficient samples that can be obtained single-center studies. Therefore, collaboration between investigators needed to establish large biobanks well-defined samples. Standardized protocols for biobanking prerequisite ensure statistical power...
Background Retinal optical coherence tomography (OCT) is an imaging biomarker for neurodegeneration in multiple sclerosis (MS). In order to become validated as outcome measure multicenter studies, reliable quality control (QC) criteria with high inter-rater agreement are required. Methods/Principal Findings A prospective multicentre study on developing consensus QC retinal OCT MS: (1) a literature review criteria; (2) application of these training set 101 scans from patients MS; (3) kappa...
To test blood and CSF neurofilament light chain (NfL) levels in relation to disease progression survival amyotrophic lateral sclerosis (ALS).
ObjectiveNeuronal damage is the morphological substrate of persisting neurological disability. Neurofilaments (Nf) are cytoskeletal proteins neurons and their release into cerebrospinal fluid has shown encouraging results as a biomarker for neurodegeneration. This study aimed to validate quantification Nf light chain (NfL) in blood samples, biofluid source easily accessible longitudinal studies. MethodsWe developed applied highly sensitive electrochemiluminescence (ECL) based immunoassay NfL...
To develop consensus recommendations for reporting of quantitative optical coherence tomography (OCT) study results.A panel experienced OCT researchers (including 11 neurologists, 2 ophthalmologists, and neuroscientists) discussed requirements performing analyses retinal morphology developed a list initial based on experience previous studies. The was subsequently revised during several meetings the coordinating group.We provide 9-point checklist encompassing aspects deemed relevant when...
Background: Retinal optical coherence tomography (OCT) permits quantification of retinal layer atrophy relevant to assessment neurodegeneration in multiple sclerosis (MS). Measurement artefacts may limit the use OCT MS research. Objective: An expert task force convened with aim provide guidance on validated quality control (QC) criteria for research and clinical trials. Methods: A prospective multi-centre ( n = 13) study. Peripapillary ring scan QC rating an training set 50) was followed by...
Abstract Medical artificial intelligence (AI) offers great potential for recognizing signs of health conditions in retinal images and expediting the diagnosis eye diseases systemic disorders 1 . However, development AI models requires substantial annotation are usually task-specific with limited generalizability to different clinical applications 2 Here, we present RETFound, a foundation model that learns generalizable representations from unlabelled provides basis label-efficient adaptation...
Making an accurate diagnosis of optic disc drusen (ODD) is important as part the work-up for possible life-threatening edema. It also to follow slowly progressive visual field defects many patients with ODD experience. The introduction enhanced depth imaging optical coherence tomography (EDI-OCT) has improved visualization more deeply buried ODD. There is, however, no consensus regarding using OCT. purpose this study was develop a recommendation diagnosing OCT.The members Optic Disc Drusen...
Identifing potential screening tests for future cognitive decline is a priority developing treatments and the prevention of dementia.To examine retinal nerve fiber layer (RNFL) thickness measurement in identifying those at greater risk large community cohort healthy people.UK Biobank prospective, multicenter, community-based study UK residents aged 40 to 69 years enrollment who underwent baseline optical coherence tomography imaging, physical examination, questionnaire. The pilot phase was...
To update the consensus recommendations for reporting of quantitative optical coherence tomography (OCT) study results, thus revising previously published Advised Protocol OCT Study Terminology and Elements (APOSTEL) recommendations.To identify studies we performed a PubMed search terms "quantitative" "optical tomography" from 2015 to 2017. Corresponding authors identified publications were invited provide feedback on initial APOSTEL via online surveys following principle modified Delphi...
Cadaveric studies have shown disease-related neurodegeneration and other morphological abnormalities in the retina of individuals with Parkinson disease (PD); however, it remains unclear whether this can be reliably detected vivo imaging. We investigated inner retinal anatomy, measured using optical coherence tomography (OCT), prevalent PD subsequently assessed association these markers development a prospective research cohort.
Multiple sclerosis is increasingly being recognized as a neurodegenerative disease that triggered by inflammatory attack of the CNS. As yet there no satisfactory treatment. Using experimental allergic encephalo myelitis (EAE), an animal model multiple sclerosis, we demonstrate cannabinoid system neuroprotective during EAE. Mice deficient in receptor CB1 tolerate and excitotoxic insults poorly develop substantial neurodegeneration following immune In addition, exogenous agonists can provide...
To test whether biomarkers for axonal degeneration correlated with clinical subtypes and were of use in predicting progression ALS.Patients ALS (n = 69), patients Alzheimer disease (AD; n 73), age-matched controls 33) included this prospective study. CSF levels tau protein neurofilaments (NfHSMI35) measured using ELISA. In 49 ALS, follow-up data available (median 7 months).CSF NfHSMI35 five times higher (1.7 ng/mL) than (0.3 ng/mL, p < 0.001) 10 AD (0.14 0.001). values also upper motor...
Disease progression in multiple sclerosis occurs within the interface of glial activation and gliosis. This study aimed to investigate relationship between biomarkers different cell responses: (i) disease dynamics clinical subtypes sclerosis; (ii) disability; (iii) cross‐validate these findings a post‐mortem study. To address first goal, 51 patients with [20 relapsing remitting (RR), 21 secondary progressive (SP) 10 primary (PP)] neurological control were included. Disability was assessed...