Albert Saiz
A5072712902- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Autoimmune Neurological Disorders and Treatments
- Systemic Lupus Erythematosus Research
- Polyomavirus and related diseases
- Genetics and Neurodevelopmental Disorders
- Genetic Neurodegenerative Diseases
- Prion Diseases and Protein Misfolding
- Myasthenia Gravis and Thymoma
- Advanced Neuroimaging Techniques and Applications
- Immunotherapy and Immune Responses
- RNA regulation and disease
- Retinal and Optic Conditions
- Ion channel regulation and function
- Neuroinflammation and Neurodegeneration Mechanisms
- Ocular Diseases and Behçet’s Syndrome
- T-cell and B-cell Immunology
- Systemic Sclerosis and Related Diseases
- Autoimmune and Inflammatory Disorders Research
- Long-Term Effects of COVID-19
- Protein Tyrosine Phosphatases
- Cellular transport and secretion
- CNS Lymphoma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Functional Brain Connectivity Studies
Universitat de Barcelona
2015-2024
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2015-2024
Hospital Clínic de Barcelona
2015-2024
Services Hospital
2012-2024
Fundació Clínic per a la Recerca Biomèdica
2023-2024
University of Pennsylvania
2008-2023
Institució Catalana de Recerca i Estudis Avançats
2016-2023
Inserm
1999-2023
Centro de Investigación Biomédica en Red
2020-2023
Centre for Biomedical Network Research on Rare Diseases
2020-2023
The association of high levels autoantibodies to glutamic acid decarboxylase (GAD-ab) and stiff-person syndrome (SPS) is well known. However, the full spectrum neurological syndromes associated with GAD-ab not established. In addition, these patients usually present type 1 diabetes mellitus (DM1) that could justify presence levels. To clarify issues, we reviewed clinical immunological features in whom were detected a reference centre for DM1 detection antineuronal antibodies suspected...
Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disease of the central nervous system and associated with autoantibodies to anti-aquaporin-4 (AQP4-IgG) in approximately two thirds patients. Interleukin-6 involved pathogenesis disorder. Satralizumab a humanized monoclonal antibody targeting interleukin-6 receptor. The efficacy satralizumab added immunosuppressant treatment patients NMOSD unclear.In phase 3, randomized, double-blind, placebo-controlled trial, we randomly...
To report the clinical, radiological, and immunological association of demyelinating disorders with anti–Nmethyl- D-aspartate receptor (NMDAR) encephalitis.Clinical radiological analysis was done a cohort 691 patients anti-NMDAR encephalitis. Determination antibodies to NMDAR, aquaporin-4 (AQP4), myelin oligodendrocyte glycoprotein (MOG) performed using brain immunohistochemistry cell-based assays.Twenty-three encephalitis had prominent magnetic resonance imaging (MRI) and/or clinical...
We report the clinical features, comorbidities, and outcome of 22 newly identified patients with antibodies to α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR).This was a retrospective review diagnosed between May 2009 March 2014. Immunologic techniques have been reported previously.Patients' median age 62 years (range 23-81; 14 female). Four syndromes were identified: 12 (55%) presented distinctive limbic encephalitis (LE), 8 (36%) dysfunction along multifocal/diffuse...
We investigated a series of patients with LGI1 antibody (Ab)-related cognitive deterioration to determine the clinical presentation, long-term outcome, and Ab evolution.We retrospectively analyzed information 76 Ab-related deterioration. Presenting syndromes were classified as limbic encephalitis (LE), non-LE, or encephalopathy (normal MRI no CSF pleocytosis). Frequency relapses outcome assessed in 48 prolonged follow-up (median 39 months, range 18-200).Sixty-three (83%) developed LE, 3 (4%)...
Background and objective: We explored which clinical biochemical variables predict conversion from clinically isolated syndrome (CIS) to definite multiple sclerosis (CDMS) in a large international cohort. Methods: Thirty-three centres provided serum samples 1047 CIS cases with at least two years’ follow-up. Age, sex, presentation, T2-hyperintense lesions, cerebrospinal fluid (CSF) oligoclonal bands (OCBs), CSF IgG index, cell count, 25-hydroxyvitamin D3 (25-OH-D), cotinine titres against...
γ-Aminobutyric acid-B receptor antibodies (GABA(B)R-ab) were recently described in 15 patients with limbic encephalitis (LE), associated small-cell lung cancer (SCLC) or concurrent glutamic acid decarboxylase (GAD) antibodies. We analyzed the frequency of GABA(B)R-ab 147 LE neurologic syndromes GAD-ab.We examined presence 70 (33 paraneoplastic onconeural antibodies, 18 without [5 Gad-ab], and 19 idiopathic either GAD-ab patients] seronegative) 77 GAD-ab-associated other than (29 stiff-person...
Objective: We aimed to report the frequency and implications of antibodies myelin oligodendrocyte glycoprotein (MOG-ab) in adults with demyelinating syndromes suspicious for neuromyelitis optica (NMO). Methods: Samples from 174 patients (48 NMO, 84 longitudinally extensive myelitis (LETM), 39 optic neuritis (ON), three acute disseminated encephalomyelitis (ADEM) who presented initially isolated LETM) were retrospectively examined AQP4-ab MOG-ab using cell-based assays. Results: found 17...
<h3>Objective:</h3> The clinical characteristics of patients with relapsing anti–NMDA receptor (NMDAR) encephalitis are not well-defined. In this study, we report the profile and outcome relapses in a series anti-NMDAR encephalitis. <h3>Methods:</h3> We did retrospective review that occurred 25 Relapses were defined as any new psychiatric or neurologic syndrome, explained by other causes, which improved after immunotherapy or, less frequently, spontaneously. <h3>Results:</h3> A total 13...
<h3>Objective</h3> Antibodies to cell surface central nervous system proteins help diagnose conditions which often respond immunotherapies. The assessment of antibody assays needs reflect their clinical utility. We report the results a multicentre study aquaporin (AQP) 4 (AQP4-Ab) in neuromyelitis optica spectrum disorders (NMOSD). <h3>Methods</h3> Coded samples from patients with (NMO) or NMOSD (101) and controls (92) were tested at 15 European diagnostic centres using 21 including live...
Objective To evaluate the association between damage to anterior and posterior visual pathway as evidence of presence retrograde anterograde trans‐synaptic degeneration in multiple sclerosis (MS). Methods We performed a longitudinal evaluation on cohort 100 patients with MS, acquiring retinal optical coherence tomography measure (peripapillary nerve fiber layer [RNFL] thickness macular volume) 3T brain magnetic resonance imaging (MRI) for (volumetry spectroscopy cortex, lesion volume within...
<h3>Objective:</h3> To assess in multiple sclerosis (MS) the effect of intense immunosuppression followed by autologous hematopoietic stem cells transplantation (AHSCT) vs mitoxantrone (MTX) on disease activity measured MRI. <h3>Methods:</h3> We conducted a multicenter, phase II, randomized trial including patients with secondary progressive or relapsing-remitting MS, documented increase last year Expanded Disability Status Scale, spite conventional therapy, and presence one more...
Little is known of glutamic acid decarboxylase antibodies (GAD-abs) in the paraneoplastic context. Clinical recognition such cases will lead to prompt tumor diagnosis and appropriate treatment.To report clinical immunological features patients with neurological syndromes (PNS) GAD-abs.Retrospective case series study investigations conducted February 2014 a center for autoimmune disorders. Fifteen GAD65-abs evaluated between 1995 2013 who fulfilled criteria definite or possible PNS without...