Olivier Outteryck
A5102964585- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Polyomavirus and related diseases
- Systemic Lupus Erythematosus Research
- Retinal and Optic Conditions
- Ocular Diseases and Behçet’s Syndrome
- Cerebral Venous Sinus Thrombosis
- Systemic Sclerosis and Related Diseases
- Full-Duplex Wireless Communications
- RNA regulation and disease
- Viral Infections and Immunology Research
- Advanced MRI Techniques and Applications
- Glaucoma and retinal disorders
- Advanced Neuroimaging Techniques and Applications
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Metabolism and Genetic Disorders
- Sarcoidosis and Beryllium Toxicity Research
- Long-Term Effects of COVID-19
- Lanthanide and Transition Metal Complexes
- Autoimmune Neurological Disorders and Treatments
- Rheumatoid Arthritis Research and Therapies
- Herpesvirus Infections and Treatments
- Myasthenia Gravis and Thymoma
- Mycobacterium research and diagnosis
- Effects of Vibration on Health
Centre Hospitalier Universitaire de Bordeaux
2022-2024
Observatoire Français de la Sclérose en Plaques
2024
Max Delbrück Center
2024
Charité - Universitätsmedizin Berlin
2024
Centre Hospitalier Universitaire de Lille
2014-2023
Université de Lille
2014-2023
Inserm
2016-2023
Lille’s Cardiology Hospital
2018-2023
Amyloidosis Foundation
2023
Hôpital Roger Salengro
2011-2022
To develop consensus recommendations for reporting of quantitative optical coherence tomography (OCT) study results.A panel experienced OCT researchers (including 11 neurologists, 2 ophthalmologists, and neuroscientists) discussed requirements performing analyses retinal morphology developed a list initial based on experience previous studies. The was subsequently revised during several meetings the coordinating group.We provide 9-point checklist encompassing aspects deemed relevant when...
Background: Retinal optical coherence tomography (OCT) permits quantification of retinal layer atrophy relevant to assessment neurodegeneration in multiple sclerosis (MS). Measurement artefacts may limit the use OCT MS research. Objective: An expert task force convened with aim provide guidance on validated quality control (QC) criteria for research and clinical trials. Methods: A prospective multi-centre ( n = 13) study. Peripapillary ring scan QC rating an training set 50) was followed by...
To update the consensus recommendations for reporting of quantitative optical coherence tomography (OCT) study results, thus revising previously published Advised Protocol OCT Study Terminology and Elements (APOSTEL) recommendations.To identify studies we performed a PubMed search terms "quantitative" "optical tomography" from 2015 to 2017. Corresponding authors identified publications were invited provide feedback on initial APOSTEL via online surveys following principle modified Delphi...
<h3>SUMMARY:</h3> Coronavirus disease 2019 (COVID-19) is a viral infection caused by the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), which spreads rapidly from person to and manifests in most symptomatic patients as respiratory illness, similar prior SARS viruses. Neurologic manifestations of COVID-19 are uncommon; those so far reported include encephalopathy, stroke large-vessel occlusion, polyneuropathy. We report unique neurologic complication patient who had extensive...
There have been few epidemiologic studies on neuromyelitis optica (NMO) and none used the recent 2006 diagnostic criteria. Here we describe clinical, laboratory, MRI, disability course of NMO in a French cohort 125 patients.We performed an observational, retrospective, multicenter study. Data were collected from September 2007 through August 2008, corresponding to endpoint We identified patients fulfilling Selection was made using hospital files specific clinical questionnaire for NMO.Mean...
<h3>Objective</h3> To compare the efficacy and risk of severe infectious events immunosuppressive agents used early as first-line therapy in patients with neuromyelitis optica spectrum disorder (NMOSD). <h3>Methods</h3> We retrospectively included NMOSD a seropositive status for aquaporin 4 or myelin oligodendrocyte glycoprotein antibodies beginning immunosuppressants within 3 years after disease onset. The main outcome was occurrence relapse initiation immunosuppressants; secondary annual...
To establish whether or not multiple sclerosis (MS) and neuromyelitis optica (NMO) are different pathological entities, we wondered MS patients NMO share the same pattern of human leukocyte antigen (HLA) predisposition.To study a putative association between susceptibility to HLA class I II loci in Caucasians.A total 39 unrelated Caucasian with six at high risk converting were studied. DNA genotyping was assessed allelic frequencies reported high-resolution level. A case-control by comparing...
<h3>Objective:</h3> The purpose of our study was to assess the influence pregnancy on course neuromyelitis optica (NMO) and impact epidural analgesia breastfeeding its activity in postpartum period. <h3>Methods:</h3> We performed a retrospective patients with NMO diagnosed according Wingerchuk criteria. noted number relapses during year before (BP), (first trimester, second third trimester), after (Y + 1: first trimester [PP2], fourth trimesters postpartum). Epidural were recorded....
<h3>Objective:</h3> To evaluate the usefulness of punctate pattern (PP) for diagnosis and follow-up patients with progressive multifocal leukoencephalopathy (PML). <h3>Methods:</h3> A cohort 20 consecutive PML, related to natalizumab (NTZ) (n = 14) or not 6), underwent 3T MRI (147 examinations). was available at presymptomatic 9 patients), symptomatic 15), immune reconstitution inflammatory syndrome (IRIS), chronic stages 20). pathologic control group without PML 80), clinically definitive...
Inherited white matter diseases are rare and heterogeneous disorders usually encountered in infancy. Adult-onset forms increasingly recognized. Our objectives were to determine relative frequencies of genetic leukoencephalopathies a cohort adult-onset patients evaluate the effectiveness systematic diagnostic approach. Inclusion criteria this retrospective study were: (i) symmetrical involvement on first available brain MRI; (ii) age onset above 16 years. Patients with acquired excluded....
Serum antibodies against myelin-oligodendrocyte-glycoprotein (MOG-IgG) are detectable in a proportion of patients with acute or relapsing neuroinflammation. It is unclear, if neuro-axonal damage occurs only an attack-dependent manner also progressively. Therefore, this study aimed to investigate longitudinally intra-retinal layer changes eyes without new optic neuritis (ON) MOG-IgG-seropositive patients.We included 38 24 ON during follow-up (F/U) [median years (IQR)] 1.9 (1.0-2.2) and 56 28...
The association of peripapillary retinal nerve fibre layer (pRNFL) and ganglion cell-inner plexiform (GCIPL) thickness with neurodegeneration in multiple sclerosis (MS) is well established. relationship the adjoining inner nuclear (INL) inflammatory disease activity less understood.The objective this paper to investigate INL volume changes MS.Methods In longitudinal, multi-centre study, optical coherence tomography (OCT) clinical data (disability status, relapses MS optic neuritis (MSON))...
Patients with myelin oligodendrocyte glycoprotein antibody (MOG-IgG)-associated disease (MOGAD) suffer from severe optic neuritis (ON) leading to retinal neuro-axonal loss, which can be quantified by optical coherence tomography (OCT). We assessed whether ON-independent atrophy detected in MOGAD. Eighty patients MOGAD and 139 healthy controls (HCs) were included. OCT data was acquired (1) Spectralis spectral domain (MOGAD: N = 66 HCs: 103) (2) Cirrus high-definition 14 36). Macular combined...
Understanding the association between clinically defined relapses and radiological activity in multiple sclerosis (MS) is essential for patient treatment therapeutic development. To investigate clinical events identified as but not associated with new T2 lesions or gadolinium-enhanced T1 on brain spinal cord magnetic resonance imaging (MRI). This multicenter observational cohort study was conducted January 2015 June 2023. Data were extracted 8, 2023, from French MS registry. All reported...
Background: The burden of multiple sclerosis (MS) includes fatigue, depression and worsening health-related quality life (HRQOL). These changes have not been yet measured in neuromyelitis optica (NMO). Our aim was to assess the HRQOL, fatigue NMO. Methods: We administered French validated self-questionnaires on HRQOL (SEP-59), (EMIF-SEP) (EHD) 40 patients followed up two centres. assessed relationship these parameters with gender, age, disability, disease duration, visual acuity NMO-antibody...
Aim: The objectives of this study were to evaluate the rate JC virus (JCV) seroconversion/seroreversion in a French cohort multiple sclerosis (MS) patients receiving natalizumab (NTZ), describe characteristics population, identify risk factors for JCV seropositivity and analyse additional value quantitative serology results context. Methods: MS from two centres, whose serological status 2011 while NTZ was known ( n=357; first-generation enzyme-linked immunosorbent assay (ELISA) test (Gen1)),...
Objectives: The aim of this study was to find, using spectral domain-optical coherence tomography (SD-OCT), retinal imaging biomarkers differentiating neuromyelitis optica spectrum disorder (NMOSD), multiple sclerosis (MS) and healthy controls (HCs). Materials methods: population composed patients with NMOSD ( n=23) or MS n=110) HCs n=75). Evaluation criteria were thickness/volume, visual acuity, low contrast vision acuity Expanded Disability Status Scale score. Results: Considering all eyes...
<h3>Objective</h3> To evaluate the frequency of asymptomatic optic nerve lesions and their role in retinal neuroaxonal loss observed multiple sclerosis (MS). <h3>Methods</h3> We included patients with remitting-relapsing MS VWIMS study (Analysis Neurodegenerative Process Within Visual Ways In Multiple Sclerosis) (ClinicalTrials.gov Identifier: 03656055). Included underwent optical coherence tomography (OCT), brain MRI, low-contrast visual acuity measurement. eyes without neuritis (MS-NON),...