A5090283264- Hereditary Neurological Disorders
- Peripheral Neuropathies and Disorders
- Neurological diseases and metabolism
- Genetic Neurodegenerative Diseases
- Amyotrophic Lateral Sclerosis Research
- Neurogenetic and Muscular Disorders Research
- Myasthenia Gravis and Thymoma
- Botulinum Toxin and Related Neurological Disorders
- Neurology and Historical Studies
- Peripheral Nerve Disorders
- RNA regulation and disease
- Pain Mechanisms and Treatments
- Vasculitis and related conditions
- Muscle Physiology and Disorders
- Autoimmune Neurological Disorders and Treatments
- RNA Research and Splicing
- Parkinson's Disease Mechanisms and Treatments
- Neurological and metabolic disorders
- Alcoholism and Thiamine Deficiency
- Multiple Myeloma Research and Treatments
- Mitochondrial Function and Pathology
- Inflammatory Myopathies and Dermatomyositis
- Nerve injury and regeneration
- Parkinson's Disease and Spinal Disorders
- Cardiomyopathy and Myosin Studies
Hôpital Pellegrin
2016-2025
Université de Bordeaux
2017-2025
Nerve Centre
2017-2023
Amyotrophic Lateral Sclerosis Association
2023
Centre Hospitalier Universitaire de Bordeaux
2016-2022
Hôpital Raymond-Poincaré
2021
Université de Limoges
2013-2020
Centre Hospitalier Universitaire de Tours
2016-2020
Hôpital Dupuytren
2015-2020
Hôpital Bretonneau
2020
Zika virus (transmitted by mosquitoes) reached French Polynesia for the first time in 2013, leading to an epidemic affecting 10% of total population. So far, it has not been known induce any neurological complications, but, a few weeks after outbreak, unexpectedly high number 42 patients presented with Guillain–Barré syndrome. We report clinical and electrophysiological characteristics this series. Males predominated sex ratio 2.82 (mean age: 46). All (except 2) were native Polynesian. At...
Amyloid neuropathy is a rare peripheral that classically presents as progressive sensory with prominent autonomic involvement.We describe 5 patients amyloid (familial polyneuropathy or acquired amyloidosis) who were initially mistaken to have chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) based on history, clinical examination, electrodiagnostic studies, and cerebrospinal fluid (CSF) analysis.The diagnosis of CIDP had been retained electrophysiological grounds for all...
Polyneuropathy associated with IgM monoclonal gammopathy and anti-myelin glycoprotein (MAG) antibodies is an immune-mediated demyelinating neuropathy. The pathophysiology of this condition likely to involve anti-MAG antibody deposition on myelin sheaths the peripheral nerves it supposed be distinct from chronic inflammatory neuropathy (CIDP), another In series, we have retrospectively reviewed clinical laboratory findings 60 patients polyneuropathy, gammopathy, antibodies. We found that...
Inherited white matter diseases are rare and heterogeneous disorders usually encountered in infancy. Adult-onset forms increasingly recognized. Our objectives were to determine relative frequencies of genetic leukoencephalopathies a cohort adult-onset patients evaluate the effectiveness systematic diagnostic approach. Inclusion criteria this retrospective study were: (i) symmetrical involvement on first available brain MRI; (ii) age onset above 16 years. Patients with acquired excluded....
To describe the clinical characteristics and outcomes of coronavirus disease 2019 (COVID-19) among patients with myasthenia gravis (MG) identify factors associated COVID-19 severity in MG.The CO-MY-COVID registry was a multicenter, retrospective, observational cohort study conducted neuromuscular referral centers general hospitals FILNEMUS (Filière Neuromusculaire) network (between March 1, 2020, June 8, 2020), including MG confirmed or highly suspected diagnosis COVID-19. diagnosed based on...
<i>Aims:</i> To describe the frequency of restless legs syndrome (RLS) in a French population randomly selected women during their third trimester pregnancy and its evolution up to 3 months after delivery identify potential factors associated with improvement RLS delivery. <i>Methods:</i> A cross-sectional questionnaire survey. <i>Results:</i> 186 pregnant living town were included. 32% affected by pregnancy. Multiple pregnancies iron intake significantly...
<b><i>Background:</i></b> Patients with multiple sclerosis (MS) report sleep disturbances (SD) and excessive daytime sleepiness (EDS) more frequently than the general population. Our objectives were to evaluate SD EDS in MS patients test reliability of subjective questionnaires. <b><i>Methods:</i></b> Demographic clinical characteristics unselected consecutive collected. Different questionnaires used assess quality sleep, sleepiness, fatigue,...
The continual discovery of disease-causing gene mutations has led to difficulties in the complex classification Charcot-Marie-Tooth diseases (CMT) that needs be revised.We recently published a proposal update inherited neuropathies. reactions from colleagues prompted us diffuse and ask people if they would ready for such change. We therefore performed an internet survey (from October 1, 2016, December 2016) included more than 300 CMT worldwide specialists (practitioners scientists) various...
Abstract The neural crest gives rise to numerous cell types, dysfunction of which contributes many disorders. Here, we report that adenosine deaminase acting on RNA (ADAR1), responsible for adenosine-to-inosine editing RNA, is required regulating the development two derivatives: melanocytes and Schwann cells. Neural specific conditional deletion Adar1 in mice leads global depigmentation absence myelin from peripheral nerves, resulting alterations melanocyte survival differentiation cells,...
Parry-Romberg syndrome (PRS) is a variant of morphea usually characterized by slowly progressive course. Clinical and radiological involvement the central nervous system may be observed in PRS. We describe 2 patients with PRS neurological symptoms (one trigeminal neuralgia associated deafness, second hemifacial pain migraine without aura) conjunction abnormal cerebral MRI including white matter T2 hyperintensities enhancement gadolinium. Despite absence specific immunosuppressive treatments,...
Das Deutsche Netzwerk Versorgungsforschung e. V. (DNVF V.) hat am 30.08.2010 getragen von den genannten im DNVF organisierten Fachgesellschaften und Organisationen, das Memorandum III "Methoden für die Versorgungsforschung" Teil 2 verabschiedet, in dieser Zeitschrift publiziert wurde [Gesundheitswesen 2010; 72: 739–748]. Register der unterscheiden sich maßgeblich nicht nur ihren Zielen Fragestellungen, sondern auch ihrem Design, Erhebungsmethoden -instrumenten sowie statistischen...
<i>Aims:</i> To perform a large and detailed epidemiologic study on restless legs syndrome (RLS) during pregnancy in European country. <i>Methods:</i> A cross-sectional questionnaire survey. The was distributed by the medical staff different outpatient waiting rooms (obstetrics gynecology department of university hospital, obstetrics private clinic, midwives, obstetrician-gynecologists, radiological centers before fetal ultrasound examination general practitioners)...
Congenital hypomyelinating neuropathy is a rare neonatal syndrome responsible for hypotonia and weakness. Nerve microscopic examination shows amyelination or hypomyelination. Recently, mutations in CNTNAP1 have been described few patients. encodes contactin-associated protein 1 (caspr-1), which an essential component of the paranodal junctions peripheral central nervous systems, necessary establishment transverse bands that stabilize axo-glial junctions. We present results nerve biopsy...