Jean‐Christophe Ouallet
A5019857973- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Systemic Sclerosis and Related Diseases
- Systemic Lupus Erythematosus Research
- Polyomavirus and related diseases
- Health Systems, Economic Evaluations, Quality of Life
- Viral Infections and Immunology Research
- Hereditary Neurological Disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Reproductive System and Pregnancy
- RNA regulation and disease
- Rheumatoid Arthritis Research and Therapies
- Inflammasome and immune disorders
- Full-Duplex Wireless Communications
- Vestibular and auditory disorders
- Advanced MRI Techniques and Applications
- Neurogenesis and neuroplasticity mechanisms
- Cerebrovascular and genetic disorders
- Healthcare cost, quality, practices
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Sphingolipid Metabolism and Signaling
- Mycobacterium research and diagnosis
- Plant Virus Research Studies
- Healthcare and Venom Research
- Herpesvirus Infections and Treatments
Centre Hospitalier Universitaire de Bordeaux
2015-2024
Observatoire Français de la Sclérose en Plaques
2007-2024
St. Josef-Hospital
2024
University of Lausanne
2024
Centre Hospitalier Universitaire de Tours
2024
University Hospital of Lausanne
2021-2024
Hôpital Pellegrin
2009-2023
Université de Bordeaux
2004-2022
Inserm
1997-2021
Hôpital Gui de Chauliac
2021
The radiologically isolated syndrome (RIS) was defined in 2009 as the presence of asymptomatic, incidentally identified demyelinating-appearing white matter lesions CNS within individuals lacking symptoms typical multiple sclerosis (MS). RIS criteria have been validated and predict transition to symptomatic MS reliably. performance that require fewer MRI is unknown. 2009-RIS subjects, by definition, fulfil three four for 2005 dissemination space (DIS) subjects fulfilling only one or two at...
<h3>Background</h3> Exogenous sexual steroids together with pregnancy have been shown to influence the risk of relapses in multiple sclerosis (MS). Treatments used during assisted reproductive techniques may consequently short term evolution MS by modifying hormonal status patient. The objective this study was determine if there an increased developing exacerbations women after vitro fertilisation (IVF). <h3>Methods</h3> and IVF data were either automatically extracted from 13 French...
To compare natalizumab and fingolimod on both clinical MRI outcomes in patients with relapsing-remitting multiple sclerosis (RRMS) from 27 centers participating the French follow-up cohort Observatoire of Multiple Sclerosis.Patients RRMS included study were aged 18 to 65 years an Expanded Disability Status Scale score 0-5.5 available brain performed within year before treatment initiation. The data collected for 326 treated 303 fingolimod. statistical analysis was using 2 different methods:...
Inherited white matter diseases are rare and heterogeneous disorders usually encountered in infancy. Adult-onset forms increasingly recognized. Our objectives were to determine relative frequencies of genetic leukoencephalopathies a cohort adult-onset patients evaluate the effectiveness systematic diagnostic approach. Inclusion criteria this retrospective study were: (i) symmetrical involvement on first available brain MRI; (ii) age onset above 16 years. Patients with acquired excluded....
<h3>Importance</h3> Younger age, oligoclonal bands, and infratentorial spinal cord lesions are factors associated with an increased 10-year risk of clinical conversion from radiologically isolated syndrome (RIS) to multiple sclerosis (MS). Whether disease-modifying therapy is beneficial for individuals RIS currently unknown. <h3>Objectives</h3> To evaluate the 2-year a event (onset symptoms MS) prospectively, identify developing early event, simulate sample size needed phase III trial...
Preliminary observations of humoral immunity against the myelin oligodendrocyte glycoprotein (MOG) in experimental allergic encephalomyelitis (EAE) and human multiple sclerosis (MS) suggest that a subset anti-MOG autoantibodies directed conformational epitopes is pathogenic predominance. Here, we provide proof marmoset EAE, reactive MOG are not only responsible for aggravating demyelination, but also an essential factor disease dissemination space within central nervous system, hallmark...
The multiple sclerosis functional composite (MSFC) includes the Paced Auditory Serial Addition test (PASAT) as a measure of cognition.We compared MSFC incorporating Symbol Digit Modalities (SDMT) (MSFC [sdmt]) to usually applied [pasat]) in sample 46 ptients with relapsing-remitting MS who were followed over five-year period. Magnetic resonance imaging was performed at baseline.The Expanded Disability Status scale (EDSS) deteriorated significantly 5 years (P < 0.01), but scores remained...
Background: Despite a growing use of rituximab (RTX) in neuromyelitis optica (NMO), data are lacking patients with refractory NMO (RNMO), defined as cases at least one relapse during immunosuppressive therapy. Objective: The purpose this study was to assess RTX maintenance therapy RNMO. Methods: Out total 305 from population-based cohort, 21 RNMO received mean follow-up period 31 months. Results: After RTX, 11 (52.3%) were free, meaning that 47.7% RTX. annualized rate decreased 1.3 0.4 (...
<h3>Background</h3> Cerebellar damage has been implicated in information processing speed (IPS) impairment associated with multiple sclerosis (MS) that might result from functional disconnection the frontocerebellar loop. Structural alterations individual posterior lobules, which cognitive functioning seems preponderant, are still unknown. Our aim was to investigate impact of grey matter (GM) volume lobules VI VIIIb on IPS persons clinically isolated syndrome (PwCIS), MS (PwMS) and healthy...
Understanding the association between clinically defined relapses and radiological activity in multiple sclerosis (MS) is essential for patient treatment therapeutic development. To investigate clinical events identified as but not associated with new T2 lesions or gadolinium-enhanced T1 on brain spinal cord magnetic resonance imaging (MRI). This multicenter observational cohort study was conducted January 2015 June 2023. Data were extracted 8, 2023, from French MS registry. All reported...
Pain is a frequent symptom during the course of multiple sclerosis (MS) but its frequency and impact at early clinical stages remain unknown.The aim this study was to establish prevalence severity pain in cohort patients recently diagnosed with MS determine evolution over 2 years. Other objectives were investigate presence baseline predictors after years on quality life (QOL).In population-based sample 69 (<6 mo), measured using questions from SEP-59 QOL questionnaire. A standardized bedside...
In this study, we compared the effectiveness of teriflunomide (TRF) and dimethyl fumarate (DMF) on both clinical MRI outcomes in patients followed prospectively Observatoire Français de la Sclérose en Plaques.A total 1,770 with relapsing-remitting multiple sclerosis (RRMS) (713 TRF 1,057 DMF) an available baseline brain were included intention to treat. The 1- 2-year postinitiation relapses, increase T2 lesions, Expanded Disability Status Scale score, reason for treatment discontinuation....
Background: Patients with multiple sclerosis who have poor adherence to treatment a higher risk of relapse than adherent patients. This study assessed to, and effectiveness convenience of, subcutaneous (sc) interferon (IFN) β-1a (Rebif®, Merck Serono SA) 44 or 22 μg three times weekly in patients relapsing (RMS) using the RebiSmart® electronic, multidose, autoinjector for 1 year.Study design: European, multicentre, observational among neurologists: inclusion criteria included RMS, Expanded...
Background and purpose BIONAT is a F rench multicentric phase IV study of natalizumab ( NTZ )‐treated relapsing−remitting multiple sclerosis (MS) patients. The this was to collect clinical, radiological biological data on 1204 patients starting , evaluate the clinical/radiological response after 2 years treatment. Methods Patients at 18 MS centres since J une 2007 were included. Good defined by absence clinical activity. Data analysed in first report focus who started least ago n = 793; 2Y...
Objectives: To identify predictors of conversion to definite multiple sclerosis (MS) in patients with a cord clinically isolated syndrome. Methods: The predictive values for MS clinical, magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) variables 114 acute partial myelitis confirmed by spinal lesion on MRI were studied. Other causes syndromes excluded. Results: was diagnosed 78 (86%) during 4.0 ± 1.9 years follow-up. Some 67 these had second clinical episode. diagnosis...
<h3>BACKGROUND AND PURPOSE:</h3> In multiple sclerosis, gadolinium enhancement is used to classify lesions as active. Regarding the need for a standardized and accurate method detection of sclerosis activity, we compared 2D-spin-echo with 3D-gradient-echo T1WI gadolinium-enhancing MS lesions. <h3>MATERIALS METHODS:</h3> Fifty-eight patients were prospectively imaged at 3T by using both 3D-gradient recalled-echo in random order after injection gadolinium. Blinded independent evaluation was...
Background Therapeutic options are limited in secondary progressive multiple sclerosis (SPMS). Open-label studies suggested efficacy of monthly IV cyclophosphamide (CPM) without induction for delaying progression but no randomized trial was conducted so far. Objective To compare CPM to methylprednisolone (MP) SPMS. Methods Randomized, double-blind clinical on two parallel groups. Patient with SPMS, a documented worsening the Expanded Disability Status Scale (EDSS) score during last year and...
To determine whether adult cases of Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS) may be related familial hemophagocytic lymphohistiocytosis (HLH) causes, we have screened patients adult-onset CLIPPERS for mutations in primary HLH-associated genes.In our cohort 36 fulfilling the criteria probable or definite according CLIPPERS-2017 criteria, conducted a first study on 12 who consented genetic testing. In these patients, systemic HLH...
Flashes of light or phosphenes are the sensation without actually entering eye. This phenomenon can be evoked by stimulation retina visual cortex brain and appear unilaterally bilaterally. From an ophthalmologic perspective, arise from photoreceptor induction mechanical,1,2 inflammatory,3 vascular4 stimuli. Therefore, it is necessary to determine origin for further management. We encountered a patient who reported having while moving his eyes laterally. performed various imaging studies...