A5077617869- Multiple Sclerosis Research Studies
- Vestibular and auditory disorders
- Peripheral Neuropathies and Disorders
- Long-Term Effects of COVID-19
- Advanced Neuroimaging Techniques and Applications
- Amyotrophic Lateral Sclerosis Research
- Stroke Rehabilitation and Recovery
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Cognitive Science and Mapping
- Cerebral Palsy and Movement Disorders
- Ultrasound and Hyperthermia Applications
- Systemic Sclerosis and Related Diseases
- Infrared Thermography in Medicine
- Ophthalmology and Eye Disorders
- RNA regulation and disease
- Ultrasound Imaging and Elastography
- Telemedicine and Telehealth Implementation
- Alzheimer's disease research and treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Mitochondrial Function and Pathology
Inserm
2011-2020
Université de Bordeaux
2010-2020
Centre Hospitalier Universitaire de Bordeaux
2011-2020
Neurocentre Magendie
2014-2020
Observatoire Français de la Sclérose en Plaques
2012-2013
To determine MRI predictors for cognitive outcome in patients with early relapsing-remitting multiple sclerosis (MS).Forty-four recently diagnosed clinically definite MS were followed up clinical and evaluations at 1, 2, 5, 7 years underwent brain including magnetization transfer (MT) imaging baseline 2 years. Cognitive evaluation was also performed 56 matched healthy subjects baseline. testing included the Brief Repeatable Battery. Imaging parameters lesion load, parenchymal fraction (BPF),...
Cognition is frequently impaired in the early stages of multiple sclerosis (MS). The predictive value cognitive impairment on disability unknown. objective this study was to correlate and progression over 7 years. Forty-five patients, recruited after MS diagnosis, were followed for years by yearly Expanded Disability Status Scale (EDSS) Multiple Sclerosis Functional Composite (MSFC) evaluations classified as cognitively (CI) or unimpaired (CU) according neuropsychological testing at...
<h3>Objectives:</h3> To characterize the cognitive abilities of patients with primary progressive multiple sclerosis (PPMS) and relapsing-remitting (RRMS) compared healthy controls (HCs) matched for age, sex, education level while considering different characteristics PPMS RRMS to compare patterns these types sclerosis. <h3>Methods:</h3> Forty-one PPMS, 60 RRMS, 415 HCs were recruited in a cross-sectional study. Controls divided into 20 groups according level. Participants assessed large...
Background: Cognitive impairment in multiple sclerosis (MS) primarily applies to information processing speed (IPS). Objective: To evaluate psychometric properties of a new digit/symbol substitution test healthy subjects and patients with MS, assess its ability detect IPS MS. Methods: A sample MS patients, 60 relapsing–remitting (RRMS) 41 primary progressive (PPMS), 415 controls (HCs) underwent an battery, including assessment reaction times subtests the Test Attentional Performance battery...
We investigated whether diffusion tensor imaging (DTI) could reveal early hippocampal damage and clinically relevant correlates of memory impairment in persons with isolated syndrome (CIS) suggestive multiple sclerosis (MS).A total 37 CIS, 32 MS 36 controls prospectively included from 2011 to 2014 were tested for cognitive performances scanned 3T-magnetic resonance (MRI) assess volumetric DTI changes within the hippocampus, whole brain volume T2-lesion load.While there was no atrophy CIS...
<h3>Background</h3> Cerebellar damage has been implicated in information processing speed (IPS) impairment associated with multiple sclerosis (MS) that might result from functional disconnection the frontocerebellar loop. Structural alterations individual posterior lobules, which cognitive functioning seems preponderant, are still unknown. Our aim was to investigate impact of grey matter (GM) volume lobules VI VIIIb on IPS persons clinically isolated syndrome (PwCIS), MS (PwMS) and healthy...
The posterior cerebellar lobules seem to be the anatomical substrate of cognitive processes, but their microstructural alterations in multiple sclerosis (MS) remain unclear.To correlate diffusion metrics VI VIIIb persons with clinically isolated syndrome (PwCIS) and cognitively impaired MS (CIPwMS) performances.Sixty-nine patients (37 PwCIS, 32 CIPwMS) 36 matched healthy subjects (HS) underwent 3T magnetic resonance imaging, including 3D T1-weighted tensor imaging (DTI). Fractional...
Background Depressive mood and other emotional symptoms are common in multiple sclerosis (MS). The patient-reported outcome version of the “Echelle d’Humeur Dépressive” (EHD-PRO) aims to differentiate between two dimensions depressive people living with MS (PwMS). Objectives First, compare EHD-PRO assessment its dimensions, lack control blunting, a large sample healthy controls (HCs) samples PwMS, relapsing-remitting (RRMS) primary progressive (PPMS); second, analyse relationships scores...
Domains encompassing emotional disorders in relapsing-remitting MS (RRMS) patients are still unclear.We performed a 24-month, multicenter, single-arm, prospective study. RRMS started IFN-β treatment at baseline. The primary endpoint was lack of control, measured using the "Echelle d'HumeurDépressive" (EHD) scale three times baseline and 10 post-treatment visits. Secondary endpoints were blunting, irritability, fatigue, depression anxiety. A linear mixed covariance model assessed change from...