A5070444892- Multiple Sclerosis Research Studies
- Systemic Lupus Erythematosus Research
- Peripheral Neuropathies and Disorders
- Retinal and Optic Conditions
- Ocular Diseases and Behçet’s Syndrome
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Neuroinflammation and Neurodegeneration Mechanisms
- Ophthalmology and Eye Disorders
- Advanced Neuroimaging Techniques and Applications
- Systemic Sclerosis and Related Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Amyotrophic Lateral Sclerosis Research
- CNS Lymphoma Diagnosis and Treatment
- Alzheimer's disease research and treatments
- Mechanical Circulatory Support Devices
- Neurological and metabolic disorders
- Retinal Diseases and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Lysosomal Storage Disorders Research
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Arrest and Resuscitation
- Long-Term Effects of COVID-19
- Glycogen Storage Diseases and Myoclonus
- Photoacoustic and Ultrasonic Imaging
Freie Universität Berlin
2017-2025
Charité - Universitätsmedizin Berlin
2016-2025
Max Delbrück Center
2019-2025
Humboldt-Universität zu Berlin
2017-2025
University of California, San Francisco
2020-2025
University College London
2018-2024
National Hospital for Neurology and Neurosurgery
2021-2024
Einstein Center Digital Future
2024
Moorfields Eye Hospital NHS Foundation Trust
2024
Ente Ospedaliero Cantonale
2024
Antibodies against myelin oligodendrocyte glycoprotein (MOG-IgG) have been reported in patients with aquaporin-4 antibody (AQP4-IgG)-negative neuromyelitis optica spectrum disorders (NMOSD). The objective of this study was to describe optic neuritis (ON)-induced neuro-axonal damage the retina MOG-IgG-positive comparison AQP4-IgG-positive NMOSD patients.Afferent visual system following ON bilaterally assessed 16 a history and compared that patients. In addition, healthy controls matched for...
In this study (trial registration: NCT02166021), we aimed to evaluate the optimal way of administration, safety and clinical efficacy mesenchymal stem cell (MSC) transplantation in patients with active progressive multiple sclerosis. Forty-eight (28 males 20 females) sclerosis (Expanded Disability Status Scale: 3.0-6.5, mean : 5.6 ± 0.8, age: 47.5 12.3) evidence either worsening or activity during previous year, were enrolled (between 2015 2018). Patients randomized into three groups treated...
<h3>Objective:</h3> To trace microstructural changes in patients with aquaporin-4 antibody (AQP4-ab)-seropositive neuromyelitis optica spectrum disorders (NMOSDs) by investigating the afferent visual system without clinically overt symptoms or pathway lesions. <h3>Methods:</h3> Of 51 screened NMOSD from a longitudinal observational cohort study, we compared 6 AQP4-ab–seropositive longitudinally extensive transverse myelitis (LETM) but no history of optic neuritis (ON) other bout (NMOSD-LETM)...
Objectives Neuromyelitis optica spectrum disorders (NMOSD) are inflammatory conditions of the central nervous system and an important differential diagnosis multiple sclerosis (MS). Unlike MS, course is usually relapsing, it unclear, if progressive neurodegeneration contributes to disability. Therefore, we aimed investigate retinal neuroaxonal damage occurs in aquaporin4-antibody-seropositive NMOSD. Methods Out 157 patients with NMOSD screened, 94 eyes 51 without optic neuritis (ON) during...
To determine optic nerve and retinal damage in aquaporin-4 antibody (AQP4-IgG)-seropositive neuromyelitis optica spectrum disorders (NMOSD) a large international cohort after previous studies have been limited by small heterogeneous cohorts.The cross-sectional Collaborative Retrospective Study on optical coherence tomography (OCT) collected retrospective data from 22 centers. Of 653 screened participants, we included 283 AQP4-IgG-seropositive patients with NMOSD 72 healthy controls (HCs)....
Neuromyelitis optica spectrum disorder (NMOSD) is a frequently disabling neuroinflammatory syndrome with relapsing course. Blood-based disease severity and prognostic biomarkers for NMOSD are yet unmet clinical need. Here, we evaluated serum glial fibrillary acidic protein (sGFAP) neurofilament light (sNfL) as in patients aquaporin-4 immunoglobulin (Ig)G positive (AQP4-IgG+) NMOSD.sGFAP sNfL were determined by single-molecule array technology prospective cohort of 33 AQP4-IgG+ NMOSD, 32...
Importance Mechanisms contributing to disability accumulation in multiple sclerosis (MS) are poorly understood. Blood neurofilament light chain (NfL) level, a marker of neuroaxonal injury, correlates robustly with disease activity people MS (MS); however, data on the association between NfL level and have been conflicting. Objective To determine whether when levels elevated context confirmed worsening (CDW). Design, Setting, Participants This study included 2 observational cohorts: results...
While neurodegeneration underlies the pathological basis for permanent disability in multiple sclerosis (MS), predictive biomarkers progression are lacking. Using an animal model of chronic MS, we find that synaptic injury precedes neuronal loss and identify thinning inner plexiform layer (IPL) as early feature inflammatory demyelination—prior to symptom onset. As domains anatomically segregated retina can be monitored longitudinally, hypothesize IPL could represent a biomarker MS....
Serum antibodies against myelin-oligodendrocyte-glycoprotein (MOG-IgG) are detectable in a proportion of patients with acute or relapsing neuroinflammation. It is unclear, if neuro-axonal damage occurs only an attack-dependent manner also progressively. Therefore, this study aimed to investigate longitudinally intra-retinal layer changes eyes without new optic neuritis (ON) MOG-IgG-seropositive patients.We included 38 24 ON during follow-up (F/U) [median years (IQR)] 1.9 (1.0-2.2) and 56 28...
Patients with myelin oligodendrocyte glycoprotein antibody (MOG-IgG)-associated disease (MOGAD) suffer from severe optic neuritis (ON) leading to retinal neuro-axonal loss, which can be quantified by optical coherence tomography (OCT). We assessed whether ON-independent atrophy detected in MOGAD. Eighty patients MOGAD and 139 healthy controls (HCs) were included. OCT data was acquired (1) Spectralis spectral domain (MOGAD: N = 66 HCs: 103) (2) Cirrus high-definition 14 36). Macular combined...
Abstract Background Hyperreflective retinal foci (HRF) visualized by optical coherence tomography (OCT) potentially represent clusters of microglia. We compared HRF frequencies and their association with neurodegeneration between people clinically isolated syndrome (pwCIS), multiple sclerosis (pwMS), aquaporin 4‐IgG positive neuromyelitis optica spectrum disorder (pwNMOSD), healthy controls (HC)—as well as eyes (ON + eyes) without a history optic neuritis − eyes). Methods Cross‐sectional...
Aquaporin-4 antibody positive (AQP4+) neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) are two distinct antibody-mediated neuroinflammatory diseases. Diffusion Tensor Imaging (DTI) Neurite Orientation Dispersion Density (NODDI) advanced diffusion-weighted MRI models providing quantitative metrics sensitive to cerebral microstructural changes. This study aims differentiate brain tissue damage in NMOSD MOGAD from...
Vitamin B12 (B12) plays a critical role in fatty- and amino-acid metabolism nucleotide synthesis. While the association between deficiency neurological dysfunction is well-known, exact threshold for adequacy remains undefined terms of functional impairment evidence injury. The objective was to assess whether levels within current normal range cohort healthy older adults may be associated with measurable injury or dysfunction. We enrolled 231 elderly volunteers (median age 71.2 years old)...
<h3>Objective</h3> To investigate disease-specific foveal shape changes in patients with neuromyelitis optica spectrum disorders (NMOSDs) using morphometry. <h3>Methods</h3> This cross-sectional study included macular spectral domain optical coherence tomography scans of 52 eyes from 28 aquaporin-4 immunoglobulin G (AQP4-IgG)-seropositive NMOSD, 116 60 MS, and 123 62 healthy controls (HCs), retrospectively, an independent confirmatory cohort comprised 33/33 NMOSD/MS. The fovea was...