Marta Radaelli
A5009261153- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Systemic Lupus Erythematosus Research
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Polyomavirus and related diseases
- Rheumatoid Arthritis Research and Therapies
- Advanced Neuroimaging Techniques and Applications
- Systemic Sclerosis and Related Diseases
- Retinal and Optic Conditions
- Ocular Diseases and Behçet’s Syndrome
- Reproductive System and Pregnancy
- Neurogenesis and neuroplasticity mechanisms
- Cytokine Signaling Pathways and Interactions
- Autoimmune and Inflammatory Disorders Research
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Cerebrospinal fluid and hydrocephalus
- Botulinum Toxin and Related Neurological Disorders
- Neurogenetic and Muscular Disorders Research
- Neural dynamics and brain function
- CNS Lymphoma Diagnosis and Treatment
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Digital Mental Health Interventions
- Pregnancy and Medication Impact
Istituti di Ricovero e Cura a Carattere Scientifico
2010-2024
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2009-2024
Charité - Universitätsmedizin Berlin
2021-2024
Freie Universität Berlin
2021-2024
Max Delbrück Center
2021-2024
Humboldt-Universität zu Berlin
2021-2024
MedStar Washington Hospital Center
2024
Einstein Center Digital Future
2024
Vita-Salute San Raffaele University
2012-2023
Ospedale Papa Giovanni XXIII
2020-2023
Abstract We evaluated the effect of DMTs on Covid‐19 severity in patients with MS, a pooled‐analysis two large cohorts from Italy and France. The association baseline characteristics was assessed by multivariate ordinal‐logistic models pooled fixed‐effect meta‐analysis. 1066 MS 721 France were included. In model, anti‐CD20 therapies significantly associated (OR = 2.05, 95%CI 1.39–3.02, p < 0.001) severity, whereas interferon indicated decreased risk 0.42, 0.18–0.99, 0.047). This confirms...
Abstract Innovative pro-regenerative treatment strategies for progressive multiple sclerosis (PMS), combining neuroprotection and immunomodulation, represent an unmet need. Neural precursor cells (NPCs) transplanted in animal models of have shown preclinical efficacy by promoting remyelination releasing molecules sustaining trophic support neural plasticity. Here we present the results STEMS, a prospective, therapeutic exploratory, non-randomized, open-label, single-dose-finding phase 1...
Objective: To investigate resting state (RS) functional connectivity (FC) abnormalities within the principal brain networks in a large cohort of multiple sclerosis (MS) patients, to define trajectory FC changes over disease stages and their relation with clinical structural magnetic resonance imaging (MRI) measures. Methods: RS (fMRI), clinical, neuropsychological evaluation were obtained from 215 MS patients 98 healthy controls. Connectivity correlations clinical/neuropsychological/imaging...
To assess fetal risk after pregnancy exposure to natalizumab in women with multiple sclerosis (MS), a specific focus on spontaneous abortion (SA) and congenital anomalies (CA).Data of all pregnancies occurring between 2009 2015 patients MS treated referring 19 participating sites were collected compared those untreated injectable immunomodulatory agents. Rates SA CA also reported the Italian population. Multivariable logistic linear regression models performed.A total 92 tracked 83 women. In...
Objectives To validate imaging features able to discriminate neuromyelitis optica spectrum disorders from multiple sclerosis with conventional magnetic resonance (MRI). Methods In this cross‐sectional study, brain and spinal cord scans were evaluated 116 disorder patients (98 seropositive 18 seronegative) in chronic disease phase 65 age‐, sex‐, duration–matched patients. identify independent predictors of diagnosis, after assessing the prevalence typical/atypical findings, original cohort...
It is unclear how multiple sclerosis (MS) affects the severity of COVID-19. The aim this study to compare COVID-19-related outcomes collected in an Italian cohort patients with MS expected age- and sex-matched population.Hospitalization, intensive care unit (ICU) admission, death after COVID-19 diagnosis 1,362 were compared population a retrospective observational case-cohort population-based control. observed vs events whole different subgroups (higher risk: Expanded Disability Status Scale...
To determine optic nerve and retinal damage in aquaporin-4 antibody (AQP4-IgG)-seropositive neuromyelitis optica spectrum disorders (NMOSD) a large international cohort after previous studies have been limited by small heterogeneous cohorts.The cross-sectional Collaborative Retrospective Study on optical coherence tomography (OCT) collected retrospective data from 22 centers. Of 653 screened participants, we included 283 AQP4-IgG-seropositive patients with NMOSD 72 healthy controls (HCs)....
To determine whether autologous hematopoietic stem cell transplantation (aHSCT) is able to induce durable disease remission in people with multiple sclerosis (MS), we analyzed the long-term outcomes after a large cohort of patients MS.To be included, minimum dataset (consisting age, MS phenotype, Expanded Disability Status Scale [EDSS] score at baseline, information on technology, and least 1 follow-up visit transplantation) was required.Two hundred ten were included (relapsing-remitting...
<h3>Objective</h3> To assess relapses, disability progression and the role of disease modifying drugs (DMDs) in year after delivery women with multiple sclerosis (MS). <h3>Methods</h3> We prospectively followed-up pregnancies occurring between 2002 2008 MS, recruited from 21 Italian MS centres. The risk relapses was assessed using time-dependent Cox regression analysis. <h3>Results</h3> 350 out 423 were (pregnancies not resulting live birth a postpartum follow-up period shorter than 1...
Objective: To assess the long-term benefit-risk profile of repeated courses rituximab in Caucasian patients affected by neuromyelitis optica (NMO) and related disorders, everyday clinical practice. Methods: This is a prospective observational study performed at San Raffaele Hospital, Milan, Italy. From February 2006, we recruited 21 NMO spectrum disorders (NMOSD) whom underwent least one cycle intravenous (i.v.) then were followed for 2 years. Results: At mean follow-up time 48 months,...
Abstract The hippocampus is part of the default‐mode network (DMN) and functionally hit early in multiple sclerosis (MS). Hippocampal DMN dysfunctions have been associated with depression, both patients MS major depressive disorders. We hypothesized that white matter lesions may contribute, through a disconnection mechanism, to hippocampal dysfunction. To test this, we assessed relationship between resting‐state (RS) functional connectivity (FC) abnormalities brain T2 lesion volumes presence...
<h3>Objective</h3> To assess the prognostic role of serum neurofilament light chains (NfL) for clinically defined multiple sclerosis (CDMS) and McDonald 2017 (MS) in patients with isolated syndromes (CIS). <h3>Methods</h3> We retrospectively analyzed data admitted to our neurologic department between 2000 2015 a first demyelinating event. evaluated baseline NfL addition CSF, MRI, clinical data. <h3>Results</h3> Among 222 who were enrolled (mean follow-up 100.6 months), 45 (20%) developed...
The MuSC-19 project is an Italian cohort study open to international partners that collects data on multiple sclerosis (MS) patients with COVID-19. During the second wave of pandemic, serological tests became routinely available.To evaluate seroprevalence anti-SARS-CoV-2 antibodies according use disease-modifying therapy (DMT) in a subset included set who had undergone test.We evaluated association between positive test results and time elapsed since infection onset, age, sex, Expanded...
Astrocytes outline the perivascular space (PVS) and regulate fluid exchange through aquaporin-4 water channel. As neuromyelitis optica is an autoimmune astrocytopathy targeting aquaporin-4, we hypothesized that it could be associatied with PVS abnormalities.A total of 34 patients, 46 age- sex-matched healthy controls from two independent cohorts (exploratory validation dataset) underwent a standardized 3.0-T magnetic resonance imaging protocol including conventional diffusion tensor imaging....
A sixth month phase II multicenter-pilot trial with a low dose of the opiate antagonist Naltrexone (LDN) has been carried out in 40 patients primary progressive multiple sclerosis (PPMS). The end points were safety and tolerability. Secondary outcomes efficacy on spasticity, pain, fatigue, depression, quality life. Clinical biochemical evaluations serially performed. Protein concentration β-endorphins (BE) mRNA levels allelic variants μ-opiod receptor gene (OPRM1) analyzed. Five dropouts two...
Objective: Using diffusion tensor magnetic resonance imaging (DT MRI), we analyzed the architectural integrity of brain white matter (WM) from a large cohort MS patients to identify structural substrates concomitant presence depression and fatigue. Methods: Brain dual-echo, 3D T1-weighted DT MRI scans were acquired 147 90 gender- age-matched healthy controls (HCs). Patients stratified by (92 depressed (D), 55 not (nD)) fatigue (81 fatigued (F), 66 (nF)). Sixty-five had co-occurrence (DF)....
<h3>Objective</h3> To assess the risk of disease reactivation during pregnancy after natalizumab suspension in women with multiple sclerosis (MS). <h3>Methods</h3> Data all pregnancies occurring between 2009 and 2015 patients MS treated referring to 19 participating sites were collected compared those untreated injectable immunomodulatory agents through a 2-factor repeated measures analysis. Predictors activity assessed stepwise multivariable logistic regression models. <h3>Results</h3> A...
Background Depression occurs in about 50% of patients with multiple sclerosis. The aims this study was to investigate the prevalence depressive symptoms a multicenter MS population using Beck Inventory II (BDI II) and identify possible correlations between BDI score demographic clinical variables. Methods Data were collected multi-center, cross-sectional over period six months centers Italy II. Results 1,011 participated study. 676 subjects female, mean age 34 years (SD 10.8), EDSS 3.3...
Background: Neuroretinal atrophy is associated with whole-brain and disease activity in multiple sclerosis (MS). Recent findings support that subclinical visual pathway involvement might also occur neuromyelitis optica spectrum disorders (NMOSDs). Objective: The objective of this study to assess retinal thinning MS NMOSD its association activity. Methods: In total, 27 54 propensity-score-matched patients underwent optical coherence tomography, acuity, visual-evoked potentials at 2.4 years...