A5077637610- Multiple Sclerosis Research Studies
- SARS-CoV-2 and COVID-19 Research
- Polyomavirus and related diseases
- Peripheral Neuropathies and Disorders
- Functional Brain Connectivity Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Advanced MRI Techniques and Applications
- Nutritional Studies and Diet
- Advanced Neuroimaging Techniques and Applications
- Obesity, Physical Activity, Diet
- Blood Pressure and Hypertension Studies
- Retinal and Optic Conditions
- Family Support in Illness
- Long-Term Effects of COVID-19
- Birth, Development, and Health
- Ocular Diseases and Behçet’s Syndrome
- Neurological Disease Mechanisms and Treatments
- Diabetes Management and Research
- Neurological Disorders and Treatments
- COVID-19 and Mental Health
- Health Systems, Economic Evaluations, Quality of Life
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiovascular Health and Risk Factors
- Ultrasound and Hyperthermia Applications
- Cerebral Palsy and Movement Disorders
University of Salerno
2016-2024
University of Campania "Luigi Vanvitelli"
2017-2023
University College London
2023
Vall d'Hebron Institut de Recerca
2023
Carlo Forlanini Hospital
2023
Ospedali Riuniti San Giovanni di Dio e Ruggi d'Aragona
2023
Universitat Autònoma de Barcelona
2023
University Hospital of Basel
2023
Universitat de Barcelona
2021
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2021
Abstract Background Anxiety, depression and reduction of quality life (QoL) are common in people with multiple sclerosis (pwMS). Fear getting sick from COVID-19, government’s lockdown the imposed social distancing might have had an impact on psychological distress QoL. Objectives The aim our study was to investigate anxiety, QoL changes pwMS during SARS-CoV-2 outbreak Italy. Methods 67 a previous (less than 6 months) neuropsychological evaluation before (T0) were re-evaluated at time Italy...
It is unclear how multiple sclerosis (MS) affects the severity of COVID-19. The aim this study to compare COVID-19-related outcomes collected in an Italian cohort patients with MS expected age- and sex-matched population.Hospitalization, intensive care unit (ICU) admission, death after COVID-19 diagnosis 1,362 were compared population a retrospective observational case-cohort population-based control. observed vs events whole different subgroups (higher risk: Expanded Disability Status Scale...
The optic nerve is not one of the areas CNS that can be used to demonstrate dissemination in space (DIS) within 2017 McDonald criteria for diagnosis multiple sclerosis (MS). Objectives were (1) assess whether nerve-MRI (ON-MRI), optical coherence tomography (OCT), and visual evoked potentials (VEP) detect involvement clinically isolated syndrome (CIS) (2) evaluate contribution topography current diagnostic a prospective, multicenter cohort.
The MuSC-19 project is an Italian cohort study open to international partners that collects data on multiple sclerosis (MS) patients with COVID-19. During the second wave of pandemic, serological tests became routinely available.To evaluate seroprevalence anti-SARS-CoV-2 antibodies according use disease-modifying therapy (DMT) in a subset included set who had undergone test.We evaluated association between positive test results and time elapsed since infection onset, age, sex, Expanded...
To investigate resting-state functional connectivity (RS-FC) of the default-mode network (DMN) and sensorimotor (SMN) in relapsing remitting (RR) multiple sclerosis (MS) patients with fatigue (F) without fatigue(NF).In all, 59 RRMS 29 healthy controls (HC) underwent magnetic resonance imaging (MRI) protocol including fMRI (RS-fMRI). Functional DMN SMN was evaluated by independent component analysis (ICA). A linear regression performed to explore whether mainly driven changes observed or SMN....
The main aim of the study is to evaluate efficacy and safety profile ocrelizumab (OCR), rituximab (RTX), cladribine (CLA), employed as natalizumab (NTZ) exit strategies in relapsing-remitting multiple sclerosis (RRMS) patients at high-risk for progressive multifocal leukoencephalopathy (PML). This a multicentre, retrospective, real-world on consecutive RRMS from eleven tertiary Italian MS centres, who switched NTZ OCR, RTX, CLA January 1st, 2019, December 31st, 2019. primary outcomes were...
Background: The relationship between cognitive performance and regional thalamic atrophy in multiple sclerosis (MS) has been investigated recent studies. Objective methods: To further assess this relationship, 118 relapsing-remitting MS patients 52 healthy controls underwent a neuropsychological assessment 3T-MRI (3-Tesla magnetic resonance imaging). Cognitive performances were correlated with shape changes by using Vertex Analysis. Results: Information processing speed of...
Abstract Background The assessment of the safety and humoral response to a third booster dose BNT162b2 mRNA COVID-19 vaccine is relevant in patients with Multiple Sclerosis (pwMS) treated Ocrelizumab (OCR) or Fingolimod (FNG). Methods Serum samples were collected from Healthy controls (HCs) pwMS OCR FNG at following time-points: before first two doses (T0); 8 (T1), 16 (T2), 24 (T3) weeks after dose; within (T0b) (T1b) dose. IgG antibodies SARS-CoV-2 trimeric spike protein (Anti-TSP IgG)...
Background: Little is known about COVID-19 course and outcomes after a third booster dose of mRNA vaccine against SARS-CoV-2 (mRNA-Vax) in patients with multiple sclerosis (pwMS) treated ocrelizumab (OCR) fingolimod (FNG), which showed weakened immune response to mRNA-vax. Objectives: The aim this study was evaluate pwMS on OCR FNG receiving the mRNA-Vax compare it natalizumab (NTZ). Methods: Inclusion criteria: >18 years age, being OCR/FNG/NTZ since first dose; mRNA-Vax; no steroids use....
To date, whether hyperuricemia may represent a marker or an independent risk factor for cardiovascular disease remains unclear. This study aimed at assessing the role of in onset major events (MACE).Baseline clinical data were collected through 1998/1999 longitudinal survey as part larger Valle dell'Irno Prevenzione Project. Ten years later, MACE incidence was evaluated.A total 1175 patients (50% men, aged 25-74 years) completed study. At least one reported by 135 patients, whose mean uric...
Theory of mind (ToM) is the ability to understand and interpret another person's beliefs, intentions (cognitive ToM) emotions (affective ToM). ToM abilities have been showed be impaired in patients with Multiple Sclerosis (MS) related structural brain damage, such as global focal gray matter atrophy, microstructural white damage. Although some studies investigated association between task-based functional MRI, no date explored resting-state connectivity (RS-FC) abnormalities cognitive...
The Italian Neuroimaging Network Initiative (INNI) is an expanding repository of brain MRI data from multiple sclerosis (MS) patients recruited at four research sites. We describe the raw quality resting-state functional (RS-fMRI) time-series in INNI and inter-site variability connectivity (FC) features after unified automated preprocessing. datasets 489 MS 246 healthy control (HC) subjects were retrieved database. Raw metrics included temporal signal-to-noise ratio (tSNR), spatial...
Background: Prognostic markers are needed to guide multiple sclerosis (MS) management in the context of large availability disease-modifying drugs (DMDs). Objective: To investigate role cerebrospinal fluid (CSF) inform long-term MS outcomes. Methods: Demographic features, IgM index, oligoclonal bands (OCMB), lipid-specific OCMB, CSF neurofilament light chain protein levels, expanded disability status scale (EDSS), relapses and DMD use over study period peripapillary retinal nerve fiber layer...
Abstract Background : Anxiety, depression and reduction of quality life (QoL) are common in people with multiple sclerosis (pwMS). Fear getting sick from COVID-19, government’s lockdown the imposed social distancing might have an impact on psychological distress QoL. Objectives The aim our study was to investigate anxiety, QoL changes pwMS during SARS-CoV-2 outbreak Italy. Methods 67 a previous (less than 6 months) neuropsychological evaluation before (T0) were re-evaluated at time Italy...