A5006087508- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Systemic Lupus Erythematosus Research
- Polyomavirus and related diseases
- Monoclonal and Polyclonal Antibodies Research
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Telemedicine and Telehealth Implementation
- CNS Lymphoma Diagnosis and Treatment
- Drug-Induced Ocular Toxicity
- Cerebral Palsy and Movement Disorders
- Multiple Myeloma Research and Treatments
- COVID-19 and healthcare impacts
- Plant Virus Research Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Facial Nerve Paralysis Treatment and Research
- Ophthalmology and Eye Disorders
- Immunodeficiency and Autoimmune Disorders
- Protein Tyrosine Phosphatases
- Ocular Diseases and Behçet’s Syndrome
- Retinal and Optic Conditions
- Autoimmune Neurological Disorders and Treatments
University of Campania "Luigi Vanvitelli"
2021-2025
Vita-Salute San Raffaele University
2020
Antibodies to proteolipid protein-1 (PLP1-IgG), a major central myelin protein also expressed in the peripheral nervous system (PNS) as isoform DM20, have been previously identified mostly patients with multiple sclerosis (MS), unclear clinical implications. However, most studies relied on nonconformational immunoassays and included few non-MS CNS autoimmune demyelinating disorders (ADDs). We aimed investigate conformational PLP1-IgG whole ADD spectrum. devised new live cell-based assay...
Background Cerebrospinal fluid myelin oligodendrocyte glycoprotein IgG (CSF MOG-IgG) are found in a proportion of patients with MOG antibody-associated disorder (MOGAD) and have been associated severe disease presentations. However, most studies did not systematically investigate the role MOG-IgG intrathecal synthesis (ITS). Methods We retrospectively studied 960 consecutive paired serum CSF samples screened for using live cell-based assays. MOG-IgG-specific antibody index (AI ) was...
Abstract Introduction The present study aimed to explore the suitability of vocabulary knowledge (VOC) test as an accurate and reliable proxy cognitive reserve (CR) by evaluating its psychometric properties discrimination accuracy compared with other CR measures in multiple sclerosis (MS). Methods Sixty-eight consecutive people (pwMS), followed at our MS outpatient clinic, completed a clinical evaluation neuropsychological assessment including: VOC, Brief Repeatable Battery...
Abstract Objective: Cognitive impairment is a common feature of multiple sclerosis (MS), and its severity may be influenced by several factors, such as biological sex levels cognitive reserve (CR). The relationship between sex, CR, cognition has not yet been fully investigated. Therefore, the present study aimed to explore differences in CR building effect on performance MS. Method: 233 participants underwent Brief Repeatable Battery Neuropsychological Tests (BRB-N), Stroop test, Reserve...
Background: The effect of cognitive reserve (CR) on cognition in people with relapsing-remitting multiple sclerosis (pwRRMS) has been partially investigated. Objectives: We aimed to explore the long-term trajectories pwRRMS based their CR, measured using Vocabulary Knowledge Test (VOC). Methods: 78 underwent a neuropsychological evaluation at baseline and after mean follow-up 6.5 years. carried out several mixed-design ANCOVA test CR longitudinal trajectories, controlling for effects...
Abstract Introduction During the COVID-19 pandemic, ocrelizumab (OCR) infusions for MS patients were often re-scheduled because of center's disruption and concerns regarding immunosuppression. The aim present study was to assess changes in OCR schedule during first wave pandemic Italy evaluate effect delayed infusion on clinical/radiological endpoints. Methods Data extracted from Italian Register database. Standard interval dosing defined as an ≤ 30 weeks, while extended > weeks at time...
Covid-19 pandemic impacted on management of people with Multiple Sclerosis (pwMS). Level satisfaction pwMS regarding the care received by staff Centers (MSCs) during was not fully investigated. In a large patient-centered multicenter study, therapeutic adherence and quality MSCs assessed.In April-May 2021, an online survey widespread 16 Italian MSCs. Frequencies, percentages and/or means standard deviations were calculated to describe sample. ANOVAs performed evaluate effect sociodemographic...