A5023320769- Multiple Sclerosis Research Studies
- Functional Brain Connectivity Studies
- SARS-CoV-2 and COVID-19 Research
- Peripheral Neuropathies and Disorders
- Advanced Neuroimaging Techniques and Applications
- Polyomavirus and related diseases
- Long-Term Effects of COVID-19
- Systemic Lupus Erythematosus Research
- Cervical and Thoracic Myelopathy
- Rheumatoid Arthritis Research and Therapies
- Brain Tumor Detection and Classification
- Advanced MRI Techniques and Applications
- Amyotrophic Lateral Sclerosis Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Medical Imaging and Analysis
- Ultrasound Imaging and Elastography
- AI in cancer detection
- COVID-19 Clinical Research Studies
- Neurological Disease Mechanisms and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Cell Image Analysis Techniques
- Migraine and Headache Studies
- Neural dynamics and brain function
- Cerebral Palsy and Movement Disorders
University of Campania "Luigi Vanvitelli"
2016-2025
Università della Svizzera italiana
2019-2024
Ente Ospedaliero Cantonale
2024
University College London
2019-2024
Vall d'Hebron Institut de Recerca
2023
Carlo Forlanini Hospital
2023
Universitat Autònoma de Barcelona
2023
University Hospital of Basel
2023
Vita-Salute San Raffaele University
2014-2021
Istituti di Ricovero e Cura a Carattere Scientifico
2021
Abstract Background ChatGPT is an open-source natural language processing software that replies to users’ queries. We conducted a cross-sectional study assess people living with Multiple Sclerosis’ (PwMS) preferences, satisfaction, and empathy toward two alternate responses four frequently-asked questions, one authored by group of neurologists, the other ChatGPT. Methods An online form was sent through digital communication platforms. PwMS were blind author each response asked express their...
The default-mode network (DMN) has been increasingly recognized as relevant to cognitive status.To explore DMN changes in patients with relapsing-remitting (RR) multiple sclerosis (MS) and relate these the status.Eighteen cognitively impaired (CI) eighteen preserved (CP) RRMS healthy controls (HCs), matched for age, sex education, underwent neuropsychological evaluation anatomical resting-state functional MRI (rs-fMRI). connectivity was evaluated from rs-fMRI data via independent component...
Background and purpose Depression is the most common psychiatric disorder in multiple sclerosis (MS). Self‐report depression scales are frequently used as screening, diagnostic grading instruments. This study investigated psychometric properties of Beck Inventory second edition (BDI‐II) for assessing depressive disorders a sample Italian MS patients. Methods The included 141 consecutive non‐demented patients who completed BDI‐II Chicago Multiscale (CMDI). also clinical interview,...
erenumab was safe and effective in clinical trials for the prevention of migraine. However, real-life data are still lacking. Here we report experience from an Italian real-world setting using patients with chronic migraine experiencing previous unsuccessful preventive treatments.Seventy failure to ≥4 medication classes initially received monthly 70 mg s.c. Patients without a clinically meaningful improvement, considered as > 30% reduction headache days per month, after ≥3 months therapy...
Abstract In a multicenter setting, we applied voxel‐based methods to different structural MR imaging modalities define the relative contributions of focal lesions, normal‐appearing white matter (NAWM), and gray (GM) damage their regional distribution cognitive deficits as well impairment specific domains in multiple sclerosis (MS) patients. Approval institutional review boards was obtained, together with written informed consent from all participants. Standardized neuropsychological...
<h3>BACKGROUND AND PURPOSE:</h3> The structural MR imaging correlates of cognitive impairment in multiple sclerosis are still debated. This study assessed lesional and atrophy measures white matter gray involvement patients with MS acquired 7 European sites to identify the variables most closely associated dysfunction. <h3>MATERIALS METHODS:</h3> Brain dual-echo, 3D T1-weighted, double inversion recovery scans were at 3T from 62 relapsing-remitting 65 controls. Patients least 2...
Abstract Background Anxiety, depression and reduction of quality life (QoL) are common in people with multiple sclerosis (pwMS). Fear getting sick from COVID-19, government’s lockdown the imposed social distancing might have had an impact on psychological distress QoL. Objectives The aim our study was to investigate anxiety, QoL changes pwMS during SARS-CoV-2 outbreak Italy. Methods 67 a previous (less than 6 months) neuropsychological evaluation before (T0) were re-evaluated at time Italy...
It is unclear how multiple sclerosis (MS) affects the severity of COVID-19. The aim this study to compare COVID-19-related outcomes collected in an Italian cohort patients with MS expected age- and sex-matched population.Hospitalization, intensive care unit (ICU) admission, death after COVID-19 diagnosis 1,362 were compared population a retrospective observational case-cohort population-based control. observed vs events whole different subgroups (higher risk: Expanded Disability Status Scale...
The optic nerve is not one of the areas CNS that can be used to demonstrate dissemination in space (DIS) within 2017 McDonald criteria for diagnosis multiple sclerosis (MS). Objectives were (1) assess whether nerve-MRI (ON-MRI), optical coherence tomography (OCT), and visual evoked potentials (VEP) detect involvement clinically isolated syndrome (CIS) (2) evaluate contribution topography current diagnostic a prospective, multicenter cohort.
Antibodies to proteolipid protein-1 (PLP1-IgG), a major central myelin protein also expressed in the peripheral nervous system (PNS) as isoform DM20, have been previously identified mostly patients with multiple sclerosis (MS), unclear clinical implications. However, most studies relied on nonconformational immunoassays and included few non-MS CNS autoimmune demyelinating disorders (ADDs). We aimed investigate conformational PLP1-IgG whole ADD spectrum. devised new live cell-based assay...
Abstract In this multicenter study, we performed a tractography‐based parcellation of the thalamus and its white matter connections to investigate relationship between thalamic connectivity abnormalities cognitive impairment in multiple sclerosis (MS). Dual‐echo, morphological diffusion tensor (DT) magnetic resonance imaging (MRI) scans were collected from 52 relapsing‐remitting MS patients 57 healthy controls six European centers. Patients underwent an extensive neuropsychological...
The MuSC-19 project is an Italian cohort study open to international partners that collects data on multiple sclerosis (MS) patients with COVID-19. During the second wave of pandemic, serological tests became routinely available.To evaluate seroprevalence anti-SARS-CoV-2 antibodies according use disease-modifying therapy (DMT) in a subset included set who had undergone test.We evaluated association between positive test results and time elapsed since infection onset, age, sex, Expanded...
Gay matter (GM) involvement is clinically relevant in multiple sclerosis (MS). Using source-based morphometry (SBM), we characterized GM atrophy and its 1-year evolution across different MS phenotypes.Clinical MRI data were obtained at 8 European sites from 170 healthy controls (HCs) 398 patients with (34 isolated syndrome [CIS], 226 relapsing-remitting [RRMS], 95 secondary progressive [SPMS], 43 primary [PPMS]). Fifty-seven HCs 144 underwent follow-up. Baseline loss, progression,...
Background Cerebrospinal fluid myelin oligodendrocyte glycoprotein IgG (CSF MOG-IgG) are found in a proportion of patients with MOG antibody-associated disorder (MOGAD) and have been associated severe disease presentations. However, most studies did not systematically investigate the role MOG-IgG intrathecal synthesis (ITS). Methods We retrospectively studied 960 consecutive paired serum CSF samples screened for using live cell-based assays. MOG-IgG-specific antibody index (AI ) was...
Abstract Functional gradient (FG) analysis represents an increasingly popular methodological perspective for investigating brain hierarchical organization but whether and how network hierarchy changes concomitant with functional connectivity alterations in multiple sclerosis (MS) has remained elusive. Here, we analyzed FG components to uncover possible cortical using resting‐state MRI (rs‐fMRI) data acquired 122 MS patients 97 healthy control (HC) subjects. Cortical was assessed by deriving...
To investigate resting-state functional connectivity (RS-FC) of the default-mode network (DMN) and sensorimotor (SMN) in relapsing remitting (RR) multiple sclerosis (MS) patients with fatigue (F) without fatigue(NF).In all, 59 RRMS 29 healthy controls (HC) underwent magnetic resonance imaging (MRI) protocol including fMRI (RS-fMRI). Functional DMN SMN was evaluated by independent component analysis (ICA). A linear regression performed to explore whether mainly driven changes observed or SMN....
Background and purpose In multiple sclerosis ( MS ), depression is a common disorder whose pathophysiology still debated. To gain insights into the of in , resting‐state RS ) functional connectivity FC changes default mode network DMN salience SN executive control ECN were assessed group depressed (D‐ patients appropriately matched groups. Methods Sixteen D‐ patients, 17 non‐depressed ND ‐ healthy controls 15 subjects (D‐S), age, sex education matched, cognitively preserved non‐fatigued,...
Background: A functional cortico-subcortical disconnection has been recognized in fatigued multiple sclerosis (MS) patients. Normal appearing white matter (NAWM) damage might contribute to the abovementioned disconnectivity. Objectives: To assess relationship between fatigue and microstructural NAWM relapsing-remitting (RR) MS. Methods: Sixty RRMS patients 29 healthy controls (HC) underwent a magnetic resonance imaging (MRI) protocol including diffusion tensor (DTI). Patients with mean...
The aims of the present study were to examine psychometric properties Spielberger State-Trait Anxiety Inventory (STAI-Y-1 and STAI-Y-2, respectively) in a Multiple Sclerosis (MS) population identify cut-off score detect those MS patients with high level state and/or trait anxiety who could be more vulnerable development depression cognitive defects.The STAI-Y-1 STAI-Y-2 was completed by group (n = 175) affected healthy subjects 150) matched for age, educational level, gender. In internal...