Vincenzo Dattola
A5061084171- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Polyomavirus and related diseases
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Autoimmune and Inflammatory Disorders Research
- Parkinson's Disease Mechanisms and Treatments
- Pericarditis and Cardiac Tamponade
- Neurological Complications and Syndromes
- Fungal Plant Pathogen Control
- Acute Lymphoblastic Leukemia research
- Amyotrophic Lateral Sclerosis Research
- Takotsubo Cardiomyopathy and Associated Phenomena
- Paraoxonase enzyme and polymorphisms
- Restless Legs Syndrome Research
- CAR-T cell therapy research
- Cerebral Venous Sinus Thrombosis
- Myasthenia Gravis and Thymoma
- Reproductive System and Pregnancy
- Ultrasound in Clinical Applications
- COVID-19 Impact on Reproduction
- Neurological Disease Mechanisms and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Ultrasound Imaging and Elastography
- COVID-19 and healthcare impacts
Azienda ospedaliera "Bianchi-Melacrino-Morelli"
2021-2024
Federico II University Hospital
2024
University of Naples Federico II
2021
University of Reggio Calabria
2020
E Ink (South Korea)
2018
Centro Neurolesi Bonino Pulejo
2017-2018
Almirall (Spain)
2017
University of Messina
2006-2016
Amsterdam UMC Location VUmc
2010
To prospectively investigate whether T1 changes in normal-appearing white matter (WM) and gray (GM) multiple sclerosis (MS) are global or regional their relationship to disease type.The institutional ethics review board approved study; written informed consent was obtained. Whole-brain maps were obtained 67 patients with MS 24 healthy control subjects three-dimensional fast low-angle shot flip angle-array method, correction for B(1) imperfections. Analysis of variance performed on histogram...
To verify the existence of a symptomatic form restless legs syndrome (RLS) secondary to multiple sclerosis (MS) and identify possible associated risk factors. Prospective, multicenter, case-control epidemiologic survey. Settings: Twenty sleep centers certified by Italian Association Sleep Medicine. Eight hundred sixty-one patients affected MS 649 control subjects. N/A. Data regarding demographic clinical factors, presence severity RLS, results hematologic tests, visual analysis cerebrospinal...
It is unclear how multiple sclerosis (MS) affects the severity of COVID-19. The aim this study to compare COVID-19-related outcomes collected in an Italian cohort patients with MS expected age- and sex-matched population.Hospitalization, intensive care unit (ICU) admission, death after COVID-19 diagnosis 1,362 were compared population a retrospective observational case-cohort population-based control. observed vs events whole different subgroups (higher risk: Expanded Disability Status Scale...
The MuSC-19 project is an Italian cohort study open to international partners that collects data on multiple sclerosis (MS) patients with COVID-19. During the second wave of pandemic, serological tests became routinely available.To evaluate seroprevalence anti-SARS-CoV-2 antibodies according use disease-modifying therapy (DMT) in a subset included set who had undergone test.We evaluated association between positive test results and time elapsed since infection onset, age, sex, Expanded...
Motor impairment is the most common symptom in multiple sclerosis (MS). Thus, a variety of new rehabilitative strategies, including robotic gait training, have been implemented, showing their effectiveness. The aim our study was to investigate whether an intensive preceding traditional treatment, could be useful improving and potentiating motor performance MS patients. Forty-five patients, who fulfilled inclusion criteria, were enrolled this randomized into either control group (CG) or...
Studies on the prevalence of sexual dysfunction (SD) in multiple sclerosis (MS) have shown that 40% to 80% women and 50% 90% men had complaints. Sexual function is often disregarded during consultation with healthcare professionals, SD frequently underdiagnosed. The aim this study was investigate its relationship sociodemographic disease-related factors, regard disability state, a hospital cohort MS patients, by using semistructured interview.Of 130 screened outpatients, 87 met inclusion...
Background MRI is often used as primary outcome measure in phase II clinical trials multiple sclerosis (MS). Since persistent T1 hypointense lesions are a surrogate parameter for axonal damage and demyelination, they may serve marker monitoring the efficacy of neuroprotective drugs. At present, power analysis using black hole (BH) evolution has not been performed. Objective To assess feasibility BH on serial brain MR images proof concept studies MS. Methods MRI-data obtained from 169 active...
Cerebral atrophy is a compound measure of the neurodegenerative component multiple sclerosis (MS) and conceivable outcome for clinical trials monitoring effect neuroprotective agents. In this study, we evaluate rate cerebral in 6-month period, investigate predictive explanatory value other magnetic resonance imaging (MRI) measures relation to atrophy, determine sample sizes future short-term using as primary measure.One hundred thirty-five relapsing-remitting patients underwent six monthly...
Multiple sclerosis (MS) is characterized by chronic inflammation and demyelination of the central nervous system (CNS). Accumulating data indicate that oxidative stress, leading to reactive oxygen species (ROS) production lipid peroxidation, as well elevated levels advanced glycation end products (AGE) in CNS neurons, might play a pivotal role pathogenesis number diseases with neurodegenerative aspect, such MS. Therefore, polymorphisms genes encoding endogenous free-radical scavenging...
In the general population, maternal COVID-19 is associated with worse and fetal outcomes. Two previous studies have assessed clinical outcomes in pregnant women multiple sclerosis (MS), but there are no data about
Multiple Sclerosis (MS) is characterized by motor, cognitive, and neuropsychiatric symptoms, which can occur independently. While MS traditionally considered an inflammatory disease of the white matter, degeneration gray matter increasingly recognized as important contributor to progressive cognitive decline. A protective factor against progression dysfunction in could be reserve, defined resistance brain dysfunction. Aim present study evaluate role reserve for different aspects patients...
Introduction: Currently, none of the available multiple sclerosis (MS) disease-modifying medications has been shown to stop or reverse gait disability. Recently, nabiximols tested for treatment spasticity and walking impairment in MS. Nabiximols (trade name Sativex) is an oromucosal spray formulation containing 1:1 fixed ratio delta-9-tetrahydrocannabinol cannabidiol derived from cloned Cannabis sativa L. plant. Method analysis: A single-center, prospective, parallel design, single-blind...
Pembrolizumab (mAb to PD-1) has been recently approved for the therapy of pretreated urothelial cancer. Despite efficacy, it is often accompanied by unpredictable and sometime severe immune-related (ir) adverse events (AEs). Here, we report clinical immune-biological characterization a patient with metastatic bladder cancer who developed myositis signs (M) myasthenia-like syndrome (MLS) during treatment pembrolizumab. The presented an autoimmunity-associated HLA haplotype...