A5074751133- Multiple Sclerosis Research Studies
- Transcranial Magnetic Stimulation Studies
- Stroke Rehabilitation and Recovery
- Traumatic Brain Injury Research
- Peripheral Neuropathies and Disorders
- Cerebral Palsy and Movement Disorders
- Neurological disorders and treatments
- Vestibular and auditory disorders
- Botulinum Toxin and Related Neurological Disorders
- Psychosomatic Disorders and Their Treatments
- Functional Brain Connectivity Studies
- Dementia and Cognitive Impairment Research
- Autoimmune and Inflammatory Disorders Research
- Pain Management and Treatment
- Motor Control and Adaptation
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Muscle activation and electromyography studies
- Cardiac Arrest and Resuscitation
- Pain Mechanisms and Treatments
- Advanced MRI Techniques and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Olfactory and Sensory Function Studies
- Cannabis and Cannabinoid Research
- Epilepsy research and treatment
University of Campania "Luigi Vanvitelli"
2017-2025
Azienda Ospedaliera Ospedali Riuniti Papardo Piemonte
2021
Centro Neurolesi Bonino Pulejo
2014-2021
University of Cagliari
2021
University of Messina
1989-2020
Azienda ospedaliera "Bianchi-Melacrino-Morelli"
2018-2020
Istituti di Ricovero e Cura a Carattere Scientifico
2015-2019
Magna Graecia University
2019
E Ink (South Korea)
2018
Almirall (Spain)
2017
Many studies have demonstrated the usefulness of repetitive task practice by using robotic-assisted gait training (RAGT) devices, including Lokomat, for treatment lower limb paresis. Virtual reality (VR) has proved to be a valuable tool improve neurorehabilitation training. The aim our pilot randomized clinical trial was understand neurophysiological basis motor function recovery induced association between RAGT (by Lokomat device) and VR (an animated avatar in 2D VR) studying...
The use of neurorobotic devices may improve gait recovery by entraining specific brain plasticity mechanisms, which be a key issue for successful rehabilitation using such approach. We assessed whether the wearable exoskeleton, Ekso™, could get higher performance than conventional overground training (OGT) in patients with hemiparesis due to stroke chronic phase, and foster mechanisms. enrolled forty prospective, pre-post, randomized clinical study. Twenty underwent Ekso™ (EGT)...
A large body of evidence points to a role basal ganglia dysfunction in the pathophysiology dystonia, but recent studies indicate that cerebellar may also be involved. The cerebellum influences sensorimotor adaptation by modulating plasticity primary motor cortex. Motor cortex is maladaptive patients with writer's cramp. Here we examined whether putative dystonia linked these patients' plasticity. To end compared performances and healthy control subjects reaching task involving visuomotor...
Cognitive impairment occurs frequently in post-stroke patients. This study aimed to determine the effects of a virtual reality training (VRT) with BTs-Nirvana (BTsN) on recovery cognitive functions stroke patients, using Interactive-Semi-Immersive Program (I-SIP).We enrolled 12 subjects (randomly divided into two groups: experimental group (EG); and control (CG)), who attended Laboratory Robotic Rehabilitation IRCCS Neurolesi Messina from January June 2016. The EG underwent VRT BTsN, whereas...
Background. The level of consciousness is regulated by the activation frontal parietal network since a disruption within this interregional cortical connectivity associated with breakdown. Objective. primary aim present study was to examine feasibility and safety single session repetitive transcranial magnetic stimulation (rTMS), delivered over dorsolateral prefrontal cortex (DLPFC), in patients unresponsive wakefulness syndrome (UWS). As secondary aim, we investigated efficacy rTMS DLPFC on...
Even though robotic rehabilitation is very useful to improve motor function, there no conclusive evidence on its role in reducing post-stroke spasticity. Focal muscle vibration (MV) instead reduce segmental spasticity, with a consequent positive effect function. Therefore, it could be possible strengthen the effects of by coupling MV. To this end, we designed pilot randomized controlled trial (Clinical Trial NCT03110718) that included twenty patients suffering from unilateral upper limb...
Measurements of the concentrations γ‐aminobutyric acid (GABA) and glutamate in motor cortices lentiform nuclei dystonic patients using single‐voxel 1 H magnetic resonance spectroscopy (MRS) have yielded conflicting results so far. This study aimed to investigate dynamic changes metabolite after stimulation with upper limb dystonia. Using MRS at 3 T, GABA, plus glutamine, N ‐acetylaspartate were measured bilaterally primary sensorimotor cortex, nucleus, occipital region before 5‐Hz...
Objective . The aim of our study was to better investigate the role Sativex ® in improving pain multiple sclerosis (MS) patients by means either clinical or neurophysiological assessment.
Abstract Background The Armeo Power, a rehabilitation exoskeleton that allows early treatment of motor disabilities, provides intelligent arm support in large 3‐dimensional work space, thus enabling patients to perform intensive, repetitive, and goal‐oriented exercises. This device could efficiently induce new connections facilitate plasticity phenomena potentiation. Knowledge the potential brain reservoir after damage constitutes prerequisite for an optimal strategy. Objective To identify...
Motor impairment is the most common symptom in multiple sclerosis (MS). Thus, a variety of new rehabilitative strategies, including robotic gait training, have been implemented, showing their effectiveness. The aim our study was to investigate whether an intensive preceding traditional treatment, could be useful improving and potentiating motor performance MS patients. Forty-five patients, who fulfilled inclusion criteria, were enrolled this randomized into either control group (CG) or...
Multiple sclerosis (MS) is a demyelinating disease of autoimmune originate. A large proportion patient present with cognitive deficits that negatively affect their quality life, thus, proper rehabilitation mandatory. The aim this study to evaluate the effect semi-immersive virtual reality training (sVRT) on neuropsychological and motor recovery individuals suffering from MS. We enrolled 60 MS patients, randomized into either control group (CG: 30) undergoing conventional training, or...
Disorders of consciousness (DOC) diagnosis relies on the presence or absence purposeful motor responsiveness, which characterizes minimally conscious state (MCS) and unresponsive wakefulness syndrome (UWS), respectively. Functional neuroimaging studies have raised question possible residual awareness also in clinically-defined UWS patients. The aim our study was to identify electrophysiological parameters, by means a transcranial magnetic stimulation approach, might potentially express...
Abstract MiR-34a acts as tumor suppressor microRNA (miRNA) in several cancers, including multiple myeloma (MM), by controlling the expression of target proteins involved cell cycle, differentiation and apoptosis. Here, we have investigated combination between miR-34a γ-secretase inhibitor (γSI), Sirtinol or zoledronic acid (ZOL) order to enhance inhibitory action this miRNA on its canonical targets such Notch1 SIRT1, Ras/MAPK-dependent pathways. Our data demonstrate that synthetic mimics...