A5001051661- Transcranial Magnetic Stimulation Studies
- Neurological disorders and treatments
- Analytical Chemistry and Chromatography
- Motor Control and Adaptation
- Muscle activation and electromyography studies
- Advanced Neuroimaging Techniques and Applications
- Molecular spectroscopy and chirality
- Botulinum Toxin and Related Neurological Disorders
- Chemical Synthesis and Analysis
- Neuroscience and Neural Engineering
- DNA and Nucleic Acid Chemistry
- Vestibular and auditory disorders
- Meningioma and schwannoma management
- Genetic Neurodegenerative Diseases
- Carbohydrate Chemistry and Synthesis
- Metal complexes synthesis and properties
- Pain Management and Treatment
- Intraoperative Neuromonitoring and Anesthetic Effects
- Spectroscopy and Quantum Chemical Studies
- Cell death mechanisms and regulation
- Nanoparticle-Based Drug Delivery
- Parkinson's Disease Mechanisms and Treatments
- Spinal Fractures and Fixation Techniques
- Functional Brain Connectivity Studies
- Synthesis of β-Lactam Compounds
University of Messina
2016-2025
Azienda Ospedaliera S.Giuseppe Moscati
2021
Italian Institute of Technology
2020
Istituti di Ricovero e Cura a Carattere Scientifico
2017
Policlinico San Matteo Fondazione
2017
University of Catania
2017
Neurology, Inc
2016
Azienda Ospedaliera Universitaria Policlinico "G. Martino"
2013
National Medical Research Center of Dentistry and Maxillofacial Surgery
2013
Fondazione Gimema Onlus
2010
Recent experimental work in animals has emphasized the importance of homeostatic plasticity as a means stabilizing properties neuronal circuits. Here, we report phenomenon that indicates pattern cortical healthy human subjects. The experiments combined two techniques can produce long-term effects on excitability corticospinal output neurons: transcranial direct current stimulation (TDCS) and repetitive magnetic (rTMS) left primary motor cortex. “Facilitatory preconditioning” with anodal TDCS...
Repetitive transcranial magnetic stimulation (rTMS) of human primary motor cortex (M1) changes cortical excitability at the site and distant sites without affecting simple performance. The aim this study was to explore how rTMS regional system compensates for these changes. Using functional brain imaging, activation mapped rest during freely selected finger movements after 30 min 1 Hz rTMS. increased synaptic activity in stimulated left M1 induced widespread throughout areas engaged by task....
The excitability of inhibitory circuits in patients with writer's cramp is reduced at multiple levels within the sensorimotor system, including primary motor hand area (M1). Although this may play a major role pathophysiology cramp, it still unclear what factors cause imbalance between inhibition and excitation to arise. One possibility that homeostatic mechanisms keep cortical normal physiological range are impaired. In eight healthy age-matched controls, we combined low-frequency...
<h3>Objective:</h3> To test whether abnormal sensorimotor plasticity in focal hand dystonia is a primary abnormality or merely consequence of the dystonic posture. <h3>Methods:</h3> This study used paired associative stimulation (PAS) paradigm, an experimental intervention, capable producing long term potentiation (LTP) like changes system humans. PAS involves transcranial magnetic combined with median nerve stimulation. 10 patients cranial and cervical dystonia, who showed no symptoms hand,...
Dystonia is characterized by two main pathophysiological abnormalities: 'reduced' excitability of inhibitory systems at many levels the sensorimotor system, and 'increased' plasticity neural connections in circuits a brainstem spinal level. A surprising finding recent papers has been fact that abnormalities inhibition similar to those organic dystonia are also seen patients who have psychogenic dystonia. To try determine critical feature might separate conditions, we investigated cortical...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAlamethicin incorporation in lipid bilayers: a thermodynamic studyVincenzo Rizzo, Stefan Stankowski, and Gerhard SchwarzCite this: Biochemistry 1987, 26, 10, 2751–2759Publication Date (Print):May 19, 1987Publication History Published online1 May 2002Published inissue 19 1987https://pubs.acs.org/doi/10.1021/bi00384a015https://doi.org/10.1021/bi00384a015research-articleACS PublicationsRequest reuse permissionsArticle...
Importance There is a lack of long-term efficacy and safety data on hereditary transthyretin amyloidosis with polyneuropathy (hATTR-PN) RNA interference (RNAi) therapeutics in general. This study presents the longest-term to date patisiran for hATTR-PN. Objective To present adults Design, Setting, Participants global open-label extension (OLE) APOLLO randomized clinical trial phase 2 OLE enrolled patients from 43 hospitals or centers across 19 countries between July 2015 August 2017,...
Repetitive transcranial magnetic stimulation (rTMS) has long lasting effects on cortical excitability at the site of stimulation, interconnected sites a distance and connections between them. In present experiments we have used technique transcallosal inhibition motor cortices to examine all three in same protocol. Ten healthy subjects received 900 rTMS stimuli 1 Hz from figure eight coil over left hand area. The intensity was above threshold for inducing short latency interhemispherical...
Recent studies have shown that low-frequency repetitive transcranial magnetic stimulation (rTMS) to the left dorsal premotor cortex has a lasting influence on excitability of specific neuronal subpopulations in ipsilateral primary motor hand area (M1(HAND)). Here we asked how these interactions are shaped by intensity and frequency rTMS orientation stimulating coil. We confirmed at 1 Hz an 90% active threshold (AMT) produced decrease corticospinal probed with single-pulse TMS over M1(HAND)....
This study was designed to examine whether corticocortical paired associative stimulation (cc-PAS) can modulate interhemispheric inhibition (IHI) in the human brain. Twelve healthy right-handed volunteers received 90 transcranial stimuli right and left primary motor hand area (M1HAND) at an interstimulus interval (ISI) of 8 ms. Left-to-right cc-PAS (first pulse given M1HAND) attenuated left-to-right IHI for one hour after cc-PAS. also increased corticospinal excitability conditioned M1HAND....
Repetitive transcranial magnetic stimulation (rTMS) or repetitive electrical peripheral nerve (rENS) can induce changes in the excitability of human motor cortex (M1) that is often short-lasting and variable, occurs only after prolonged periods stimulation. In 10 healthy volunteers, we used a new paired associative (rPAS) protocol to facilitate prolong effects rENS rTMS on cortical excitability. Sub-motor threshold 5 Hz right median was synchronized with submotor left M1 at constant interval...
Abstract Measurements have been made on the flow dichroism of T7 DNA as a function NaCl concentration. In high salt, our results are compatible with an optical factor −1.4 and persistence length 470 Å. The former is in agreement expectations from x‐ray diffraction structure fibrous B–DNA, latter midrange recent determinations. As salt concentration decreased, increases. relation study to other investigations current theories electrostatic contribution discussed. We note that separation...
Diffusion tensor imaging tractography provides 3-dimensional reconstruction of principal white matter tracts, but its spatial accuracy has been questioned. Navigated transcranial magnetic stimulation (nTMS) enables somatotopic mapping the motor cortex.We used maps to reconstruct corticospinal tract (CST) by integrating elements organization. We analyzed this method compared with a standard technique and verified reliability intraoperative subcortical stimulation.We prospectively collected...
Repetitive transcranial magnetic stimulation (rTMS) of the human motor hand area (M1HAND) can induce lasting changes in corticospinal excitability as indexed by a change amplitude motor-evoked potential. The plasticity-inducing effects rTMS M1HAND show substantial inter-individual variability which has been partially attributed to val66met polymorphism brain-derived neurotrophic factor (BDNF) gene. Here we used theta burst (TBS) examine whether BDNF genotype be predict expression TBS-induced...
<h3>Importance</h3> Although imaging has become a standard tool of modern medicine, its widespread use been paralleled by an increasing cumulative radiation dose to patients despite technological advancements and campaigns calling for better awareness minimization unnecessary exposures. <h3>Objective</h3> To assess patients' knowledge about medical related risks. <h3>Design, Setting, Participants</h3> A survey study hospitals in Italy was conducted; all waiting rooms procedures before...
Benign essential blepharospasm (BEB) is a focal cranial dystonia affecting eye closure. Here, we tested the hypothesis that BEB associated with abnormal plasticity of neuronal circuits mediating reflex blinks. In patients and healthy age-matched controls, used conditioning protocol introduced by Mao Evinger (2001) to induce long-term potentiation (LTP)-like in trigeminal wide dynamic range neurons blink circuit. High-frequency trains electrical stimuli were repeatedly given over right...